Zanesville may refer to some places in the United States:
- Zanesville, Ohio, population 25,361
- Zanesville High School
- The Zanesville Indians, a minor-league baseball team (1944-1950)
- The Zanesville Infants, a baseball team (1908-1909)
- The Zanesville Mark Grays, an American football team (1916–1922)
- Zanesville Municipal Airport
- Zanesville, Indiana, population 602
- Zanesville, Illinois, unincorporated
- Literature
- Zanesville (novel), a 2005 novel
- Music
- Zanesville (band) a band from Tampa, Florida
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