Zapotitlán is a word of Nahuatl origin meaning "Place of the sapodilla". It may refer to:
Places
- Guatemala
- Zapotitlán, Jutiapa
- San Francisco Zapotitlán, Suchitepéquez
- San Martín Zapotitlán, Retalhuleu
- Mexico
- Zapotitlán Tablas, Guerrero
- Zapotitlán de Vadillo, Jalisco
- Zapotitlán del Río, Oaxaca
- Zapotitlán Lagunas, Oaxaca
- Zapotitlán Palmas, Oaxaca
- Zapotitlán, Puebla
- Zapotitlán de Méndez, Puebla
Other
- Zapotitlán metro station, station of the Mexico City Metro
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