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ZNF280B
Identifiers
Aliases	ZNF280B, 5'OY11.1, D87009.C22.3, SUHW2, ZNF279, ZNF632, zinc finger protein 280B
External IDs	MGI: 1927865; HomoloGene: 62794; GeneCards: ZNF280B; OMA:ZNF280B - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.22 Start 22,484,421 bp End 22,508,742 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 C1 Start 75,868,484 bp End 75,879,068 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right testis gonad left testis superior frontal gyrus islet of Langerhans primary visual cortex prefrontal cortex Hypothalamus ventricular zone Top expressed in zygote secondary oocyte primary oocyte yolk sac tail of embryo cumulus cell hand primitive streak genital tubercle triceps brachii muscle More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140883 64453 Ensembl ENSG00000275004 ENSG00000277421 ENSMUSG00000049764 UniProt Q86YH2 Q505F4 RefSeq (mRNA) NM_080764 NM_177475 RefSeq (protein) NP_542942 NP_803426 Location (UCSC) Chr 22: 22.48 – 22.51 Mb Chr 10: 75.87 – 75.88 Mb PubMed search
Wikidata
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Zinc finger protein 280B is a protein that in humans is encoded by the ZNF280B gene.

Function

The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding.

References

1. ^ ENSG00000277421 GRCh38: Ensembl release 89: ENSG00000275004, ENSG00000277421 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000049764 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger protein 280B".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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