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ZNF398
Identifiers
Aliases	ZNF398, P51, P71, ZER6, zinc finger protein 398
External IDs	MGI: 1917856; HomoloGene: 12358; GeneCards: ZNF398; OMA:ZNF398 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q36.1 Start 149,126,416 bp End 149,183,042 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B2.3 Start 47,812,595 bp End 47,850,471 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell endothelial cell Brodmann area 23 amniotic fluid middle temporal gyrus cerebellar vermis palpebral conjunctiva pancreatic epithelial cell skin of hip mucosa of ileum Top expressed in lumbar spinal ganglion female urethra Rostral migratory stream genital tubercle secondary oocyte neural layer of retina ascending aorta lumbar subsegment of spinal cord male urethra aortic valve More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57541 272347 Ensembl ENSG00000197024 ENSMUSG00000062519 UniProt Q8TD17 n/a RefSeq (mRNA) NM_020781 NM_170686 NM_027477 NM_173034 RefSeq (protein) NP_065832 NP_733787 n/a Location (UCSC) Chr 7: 149.13 – 149.18 Mb Chr 6: 47.81 – 47.85 Mb PubMed search
Wikidata
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Zinc finger protein 398 is a protein that in humans is encoded by the ZNF398 gene.

Function

This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described, but their full length sequence has not been determined.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000197024 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000062519 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger protein 398". Retrieved 2016-02-29.

Further reading

• Conroy AT, Sharma M, Holtz AE, Wu C, Sun Z, Weigel RJ (2002). "A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alpha". J. Biol. Chem. 277 (11): 9326–34. doi:10.1074/jbc.M107702200. PMID 11779858.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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