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Zinc transporter ZIP1

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Protein found in humans
SLC39A1
Identifiers
AliasesSLC39A1, ZIP1, ZIRTL, solute carrier family 39 member 1
External IDsOMIM: 604740; MGI: 1353474; HomoloGene: 40906; GeneCards: SLC39A1; OMA:SLC39A1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)
Chromosome 1 (human)Genomic location for SLC39A1Genomic location for SLC39A1
Band1q21.3Start153,959,099 bp
End153,968,184 bp
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)
Chromosome 3 (mouse)Genomic location for SLC39A1Genomic location for SLC39A1
Band3|3 F1Start90,155,479 bp
End90,160,919 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • placenta

  • Achilles tendon

  • upper lobe of left lung

  • right lung

  • stromal cell of endometrium

  • gallbladder

  • right adrenal gland

  • left adrenal gland

  • Descending thoracic aorta

  • ascending aorta
Top expressed in
  • prostate

  • umbilical cord

  • epidermis

  • lip

  • uterus

  • placenta

  • urinary bladder

  • gallbladder

  • duodenum

  • stomach
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27173

30791

Ensembl

ENSG00000143570

ENSMUSG00000052310

UniProt

Q9NY26

Q9QZ03

RefSeq (mRNA)
NM_014437
NM_001271957
NM_001271958
NM_001271959
NM_001271960

NM_001271961

NM_013901

RefSeq (protein)
NP_001258886
NP_001258887
NP_001258888
NP_001258889
NP_001258890

NP_055252

NP_038929

Location (UCSC)Chr 1: 153.96 – 153.97 MbChr 3: 90.16 – 90.16 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000143570Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000052310Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.
  6. Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
  7. "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
  8. Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

Further reading

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
By group
SLC1–10
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SLC11–20
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SLC21–30
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SLC31–40
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SLC41–48
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SLCO1–4
Ion pumps
Symporter, Cotransporter
Antiporter (exchanger)
see also solute carrier disorders


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