Zwei (German: "two") may refer to:
- Zwei (band), a Japanese duo band
- ZWEI, a text editor
- Zwei: The Arges Adventure, 2001 video game
- Zwei: The Ilvard Insurrection, 2008 video game
- Zwei, a team in Infinite Ryvius anime series
- Zwei, a character in Phantom of Inferno anime series
- Zwei, a Pembroke Welsh Corgi in the anime series RWBY.
- Project Zwai, the codename for the video game The Evil Within
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