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Cholera
Specialty	Infectious diseases, emergency medicine

Cholera is an infection of the small intestine caused by the bacterium Vibrio cholerae. The main symptoms are watery diarrhea and vomiting. Transmission occurs primarily by drinking water or eating food that has been contaminated by the feces (waste product) of an infected person, including one with no apparent symptoms. Severe cholera, requiring hospitalization, results from the accumulation of about a million bacterial cells within the body. The severity of the diarrhea and vomiting can lead to rapid dehydration and electrolyte imbalance, and death in some cases. The primary treatment is oral rehydration therapy, typically with oral rehydration solution, to replace water and electrolytes. If this is not tolerated or does not provide improvement fast enough, intravenous fluids can also be used. Antibacterial drugs are beneficial in those with severe disease to shorten its duration and severity. Worldwide, it affects 3–5 million people and causes 100,000–130,000 deaths a year as of 2010. Cholera was one of the earliest infections to be studied by epidemiological methods.

Signs and symptoms

The primary symptoms of cholera are profuse diarrhea and vomiting of clear fluid. These symptoms usually start suddenly, half a day to five days after ingestion of the bacteria. The diarrhea is frequently described as "rice water" in nature and may have a fishy odor. An untreated person with cholera may produce 10 to 20 litres (3 to 5 US gal) of diarrhea a day. Severe cholera kills about half of affected individuals. Estimates of the ratio of asymptomatic to symptomatic infections have ranged from 3 to 100. Cholera has been nicknamed the "blue death" because a victim's skin turns bluish-gray from extreme loss of fluids.

If the severe diarrhea is not treated, it can result in life-threatening dehydration and electrolyte imbalances. Fever is rare and should raise suspicion for secondary infection. Patients can be lethargic, and might have sunken eyes, dry mouth, cold clammy skin, decreased skin turgor, or wrinkled hands and feet. Kussmaul breathing, a deep and labored breathing pattern, can occur because of acidosis from stool bicarbonate losses and lactic acidosis associated with poor perfusion. Blood pressure drops due to dehydration, peripheral pulse is rapid and thready, and urine output decreases with time. Muscle cramping and weakness, altered consciousness, seizures, or even coma due to electrolyte losses and ion shifts are common, especially in children.

Cause

Transmission is primarily by the fecal contamination of food and water caused by poor sanitation. At one time it was thought that cholera was caused by exposure to toxic gases or miasmas resulting from the fermentation of composting feces in open cesspools, as was common in all large cities before the installation of septic systems.

Susceptibility

About 100 million bacteria must typically be ingested to cause cholera in a normal healthy adult. This dose, however, is less in those with lowered gastric acidity (for instance those using proton pump inhibitors). Children are also more susceptible, with two- to four-year-olds having the highest rates of infection. Individuals' susceptibility to cholera is also affected by their blood type, with those with type O blood being the most susceptible. Persons with lowered immunity, such as persons with AIDS or children who are malnourished, are more likely to experience a severe case if they become infected. However, it should be noted that any individual, even a healthy adult in middle age, can experience a severe case, and each person's case should be measured by the loss of fluids, preferably in consultation with a professional health care provider.

The cystic fibrosis genetic mutation in humans has been said to maintain a selective advantage: heterozygous carriers of the mutation (who are thus not affected by cystic fibrosis) are more resistant to V. cholerae infections. In this model, the genetic deficiency in the cystic fibrosis transmembrane conductance regulator channel proteins interferes with bacteria binding to the gastrointestinal epithelium, thus reducing the effects of an infection.

Transmission

Cholera is typically transmitted by either contaminated food or water. In the developed world, seafood is the usual cause, while in the developing world it is more often water. Most cholera cases in developed countries are a result of transmission by food. This occurs when people harvest oysters in waters infected with sewage, as Vibrio cholerae accumulates in zooplankton and the oysters eat the zooplankton. Cholera has been found in two animal populations: shellfish and plankton.

People infected with cholera often have diarrhea, and if this highly liquid stool, colloquially referred to as "rice-water", contaminates water used by others, disease transmission may occur. The source of the contamination is typically other cholera sufferers when their untreated diarrheal discharge is allowed to get into waterways, groundwater or drinking water supplies. Drinking any infected water and eating any foods washed in the water, as well as shellfish living in the affected waterway, can cause a person to contract an infection. Cholera is rarely spread directly from person to person. Both toxic and nontoxic strains exist. Nontoxic strains can acquire toxicity through a temperate bacteriophage. Coastal cholera outbreaks typically follow zooplankton blooms, thus making cholera a zoonotic disease.

Mechanism

When consumed, most bacteria do not survive the acidic conditions of the human stomach. The few surviving bacteria conserve their energy and stored nutrients during the passage through the stomach by shutting down much protein production. When the surviving bacteria exit the stomach and reach the small intestine, they need to propel themselves through the thick mucus that lines the small intestine to get to the intestinal walls where they can thrive. V. cholerae bacteria start up production of the hollow cylindrical protein flagellin to make flagella, the cork-screw helical fibers they rotate to propel themselves through the mucus of the small intestine.

Once the cholera bacteria reach the intestinal wall they no longer need the flagella to move. The bacteria stop producing the protein flagellin to conserve energy and nutrients by changing the mix of proteins which they express in response to the changed chemical surroundings. On reaching the intestinal wall, V. cholerae start producing the toxic proteins that give the infected person a watery diarrhea. This carries the multiplying new generations of V. cholerae bacteria out into the drinking water of the next host if proper sanitation measures are not in place.

The cholera toxin (CTX or CT) is an oligomeric complex made up of six protein subunits: a single copy of the A subunit (part A), and five copies of the B subunit (part B), connected by a disulfide bond. The five B subunits form a five-membered ring that binds to GM1 gangliosides on the surface of the intestinal epithelium cells. The A1 portion of the A subunit is an enzyme that ADP-ribosylates G proteins, while the A2 chain fits into the central pore of the B subunit ring. Upon binding, the complex is taken into the cell via receptor-mediated endocytosis. Once inside the cell, the disulfide bond is reduced, and the A1 subunit is freed to bind with a human partner protein called ADP-ribosylation factor 6 (Arf6). Binding exposes its active site, allowing it to permanently ribosylate the Gs alpha subunit of the heterotrimeric G protein. This results in constitutive cAMP production, which in turn leads to secretion of H₂O, Na, K, Cl, and HCO₃ into the lumen of the small intestine and rapid dehydration. The gene encoding the cholera toxin was introduced into V. cholerae by horizontal gene transfer. Virulent strains of V. cholerae carry a variant of temperate bacteriophage called CTXf or CTXφ.

Microbiologists have studied the genetic mechanisms by which the V. cholerae bacteria turn off the production of some proteins and turn on the production of other proteins as they respond to the series of chemical environments they encounter, passing through the stomach, through the mucous layer of the small intestine, and on to the intestinal wall. Of particular interest have been the genetic mechanisms by which cholera bacteria turn on the protein production of the toxins that interact with host cell mechanisms to pump chloride ions into the small intestine, creating an ionic pressure which prevents sodium ions from entering the cell. The chloride and sodium ions create a salt-water environment in the small intestines, which through osmosis can pull up to six litres of water per day through the intestinal cells, creating the massive amounts of diarrhea. The host can become rapidly dehydrated if an appropriate mixture of dilute salt water and sugar is not taken to replace the blood's water and salts lost in the diarrhea.

By inserting separate, successive sections of V. cholerae DNA into the DNA of other bacteria, such as E. coli that would not naturally produce the protein toxins, researchers have investigated the mechanisms by which V. cholerae responds to the changing chemical environments of the stomach, mucous layers, and intestinal wall. Researchers have discovered a complex cascade of regulatory proteins controls expression of V. cholerae virulence determinants. In responding to the chemical environment at the intestinal wall, the V. cholerae bacteria produce the TcpP/TcpH proteins, which, together with the ToxR/ToxS proteins, activate the expression of the ToxT regulatory protein. ToxT then directly activates expression of virulence genes that produce the toxins, causing diarrhea in the infected person and allowing the bacteria to colonize the intestine. Current research aims at discovering "the signal that makes the cholera bacteria stop swimming and start to colonize (that is, adhere to the cells of) the small intestine."

Genetic structure

Amplified fragment length polymorphism fingerprinting of the pandemic isolates of V. cholerae has revealed variation in the genetic structure. Two clusters have been identified: Cluster I and Cluster II. For the most part, Cluster I consists of strains from the 1960s and 1970s, while Cluster II largely contains strains from the 1980s and 1990s, based on the change in the clone structure. This grouping of strains is best seen in the strains from the African continent.

Diagnosis

A rapid dip-stick test is available to determine the presence of V. cholerae. In those samples that test positive, further testing should be done to determine antibiotic resistance. In epidemic situations, a clinical diagnosis may be made by taking a patient history and doing a brief examination. Treatment is usually started without or before confirmation by laboratory analysis.

Stool and swab samples collected in the acute stage of the disease, before antibiotics have been administered, are the most useful specimens for laboratory diagnosis. If an epidemic of cholera is suspected, the most common causative agent is V. cholerae O1. If V. cholerae serogroup O1 is not isolated, the laboratory should test for V. cholerae O139. However, if neither of these organisms is isolated, it is necessary to send stool specimens to a reference laboratory. Infection with V. cholerae O139 should be reported and handled in the same manner as that caused by V. cholerae O1. The associated diarrheal illness should be referred to as cholera and must be reported in the United States.

Prevention

Although cholera may be life-threatening, prevention of the disease is normally straightforward if proper sanitation practices are followed. In developed countries, due to nearly universal advanced water treatment and sanitation practices, cholera is no longer a major health threat. The last major outbreak of cholera in the United States occurred in 1910–1911. Effective sanitation practices, if instituted and adhered to in time, are usually sufficient to stop an epidemic. There are several points along the cholera transmission path at which its spread may be halted:

• Sterilization: Proper disposal and treatment of infected fecal waste water produced by cholera victims and all contaminated materials (e.g. clothing, bedding, etc.) are essential. All materials that come in contact with cholera patients should be sanitized by washing in hot water, using chlorine bleach if possible. Hands that touch cholera patients or their clothing, bedding, etc., should be thoroughly cleaned and disinfected with chlorinated water or other effective antimicrobial agents.
• Sewage: antibacterial treatment of general sewage by chlorine, ozone, ultraviolet light or other effective treatment before it enters the waterways or underground water supplies helps prevent undiagnosed patients from inadvertently spreading the disease.
• Sources: Warnings about possible cholera contamination should be posted around contaminated water sources with directions on how to decontaminate the water (boiling, chlorination etc.) for possible use.
• Water purification: All water used for drinking, washing, or cooking should be sterilized by either boiling, chlorination, ozone water treatment, ultraviolet light sterilization (e.g. by solar water disinfection), or antimicrobial filtration in any area where cholera may be present. Chlorination and boiling are often the least expensive and most effective means of halting transmission. Cloth filters or sari filtration, though very basic, have significantly reduced the occurrence of cholera when used in poor villages in Bangladesh that rely on untreated surface water. Better antimicrobial filters, like those present in advanced individual water treatment hiking kits, are most effective. Public health education and adherence to appropriate sanitation practices are of primary importance to help prevent and control transmission of cholera and other diseases.

Surveillance

Surveillance and prompt reporting allow for containing cholera epidemics rapidly. Cholera exists as a seasonal disease in many endemic countries, occurring annually mostly during rainy seasons. Surveillance systems can provide early alerts to outbreaks, therefore leading to coordinated response and assist in preparation of preparedness plans. Efficient surveillance systems can also improve the risk assessment for potential cholera outbreaks. Understanding the seasonality and location of outbreaks provides guidance for improving cholera control activities for the most vulnerable. For prevention to be effective, it is important that cases be reported to national health authorities.

Vaccine

A number of safe and effective oral vaccines for cholera are available. Dukoral, an orally administered, inactivated whole cell vaccine, has an overall efficacy of about 52% during the first year after being given and 62% in the second year, with minimal side effects. It is available in over 60 countries. However, it is not currently recommended by the Centers for Disease Control and Prevention (CDC) for most people traveling from the United States to endemic countries. One injectable vaccine was found to be effective for two to three years. The protective efficacy was 28% lower in children less than 5 years old. However, as of 2010, it has limited availability. Work is under way to investigate the role of mass vaccination. The World Health Organization (WHO) recommends immunization of high-risk groups, such as children and people with HIV, in countries where this disease is endemic. If people are immunized broadly, herd immunity results, with a decrease in the amount of contamination in the environment.

Sari filtration

An effective and relatively cheap method to prevent transmission of V. cholera is the practice of folding a sari (a long fabric garment) multiple times to create a simple filter for drinking water. In Bangladesh this practice was found to decrease rates of Cholera by nearly half.

It involves folding a sari four to eight times to create a simple filter which reduces the amount of active V. cholera in the filtered water. Education on proper sari filter use is important, as there is a relation between poor use and an an increased risk of childhood diarrhea; soiled saris worn by women may increase transmission of intestinal infections to young children. A nylon cloth appears to work as well.

Treatment

Continued eating speeds the recovery of normal intestinal function. The World Health Organization recommends this generally for cases of diarrhea no matter what the underlying cause. A CDC training manual specifically for cholera states: “Continue to breastfeed your baby if the baby has watery diarrhea, even when traveling to get treatment. Adults and older children should continue to eat frequently.”

Fluids

The most common error in caring for patients with cholera is to underestimate the speed and volume of fluids required. In most cases, cholera can be successfully treated with oral rehydration therapy (ORT), which is highly effective, safe, and simple to administer. Rice-based solutions are preferred to glucose-based ones due to greater efficiency. In severe cases with significant dehydration, intravenous rehydration may be necessary. Ringer's lactate is the preferred solution, often with added potassium. Large volumes and continued replacement until diarrhea has subsided may be needed. Ten percent of a person's body weight in fluid may need to be given in the first two to four hours. This method was first tried on a mass scale during the Bangladesh Liberation War, and was found to have much success.

If commercially produced oral rehydration solutions are too expensive or difficult to obtain, solutions can be made. One such recipe calls for 1 liter of boiled water, 1/2 teaspoon of salt, 6 teaspoons of sugar, and added mashed banana for potassium and to improve taste.

Electrolytes

As there frequently is initially acidosis, the potassium level may be normal, even though large losses have occurred. As the dehydration is corrected, potassium levels may decrease rapidly, and thus need to be replaced. This may be done by eating foods high in potassium like bananas or green coconut water.

Antibiotics

Antibiotic treatments for one to three days shorten the course of the disease and reduce the severity of the symptoms. Use of antibiotics also reduces fluid requirements. People will recover without them, however, if sufficient hydration is maintained. The World Health Organization only recommends antibiotics in those with severe dehydration..

Doxycycline is typically used first line, although some strains of V. cholerae have shown resistance. Testing for resistance during an outbreak can help determine appropriate future choices. Other antibiotics proven to be effective include cotrimoxazole, erythromycin, tetracycline, chloramphenicol, and furazolidone. Fluoroquinolones, such as norfloxacin, also may be used, but resistance has been reported.

In many areas of the world, antibiotic resistance is increasing. In Bangladesh, for example, most cases are resistant to tetracycline, trimethoprim-sulfamethoxazole, and erythromycin. Rapid diagnostic assay methods are available for the identification of multiple drug-resistant cases. New generation antimicrobials have been discovered which are effective against in in vitro studies.

Zinc supplementation

A study in Bangladesh showed that zinc supplementation significantly reduced the duration and severity of diarrhea in children suffering from cholera. The study was conducted with 179 children, 3-14 years old, who were admitted to a hospital within 24 hours of the onset of cholera symptoms. In the study, all children received antibiotics and rehydration therapy as needed, but those in the intervention group also received zinc supplementation. Children who received zinc supplementation had 8 fewer hours of diarrheal illness and 10% less diarrheal stool volume, on average.

Prognosis

If people with cholera are treated quickly and properly, the mortality rate is less than 1%; however, with untreated cholera, the mortality rate rises to 50–60%. For certain genetic strains of cholera, such as the one present during the 2010 epidemic in Haiti and the 2004 outbreak in India, death can occur within two hours of becoming ill.

Epidemiology

Cholera affects an estimated 3–5 million people worldwide, and causes 58,000–130,000 deaths a year as of 2010. This occurs mainly in the developing world. In the early 1980s, death rates are believed to have been greater than 3 million a year. It is difficult to calculate exact numbers of cases, as many go unreported due to concerns that an outbreak may have a negative impact on the tourism of a country. Cholera remains both epidemic and endemic in many areas of the world.

Although much is known about the mechanisms behind the spread of cholera, this has not led to a full understanding of what makes cholera outbreaks happen some places and not others. Lack of treatment of human feces and lack of treatment of drinking water greatly facilitate its spread, but bodies of water can serve as a reservoir, and seafood shipped long distances can spread the disease. Cholera was not known in the Americas for most of the 20th century, but it reappeared towards the end of that century.

History

The word cholera is from Template:Lang-el kholera from χολή kholē "bile". Cholera likely has its origins in the Indian Subcontinent; it has been prevalent in the Ganges delta since ancient times. Choleras first origins, within the Indian Subcontinent, are believed to have occurred due to the result of poor living conditions as well as the presence of pools of still water; both of which are ideal living conditions for cholera to thrive. The disease first spread by trade routes (land and sea) to Russia in 1817, then, through technological advancements, to the rest of Europe, and from Europe to North America and the rest of the world. Seven cholera pandemics have occurred in the past 200 years, with the seventh originating in Indonesia in 1961.

The first cholera pandemic occurred in the Bengal region of India starting in 1817 through 1824. The disease dispersed from India to Southeast Asia, China, Japan, the Middle East, and southern Russia. The second pandemic lasted from 1827 to 1835 and affected the United States and Europe particularly due to the result of advancements in transportation, such as trade, and increased human migration, including soldiers. The third pandemic erupted in 1839, persisted until 1856, extended to North Africa, and reached South America, for the first time specifically infringing upon Brazil. Cholera hit the sub-Saharan African region during the fourth pandemic from 1863 to 1875. The fifth and sixth pandemics raged from 1881–1896 and 1899-1923. These epidemics were less fatal due to a greater understanding of the cholera bacteria. Egypt, the Arabian peninsula, Persia, India, and the Philippines were hit hardest during these epidemics, while other areas, like Germany in 1892 and Naples from 1910–1911, experienced severe outbreaks. The final pandemic originated in 1961 in Indonesia and is marked by the emergence of a new strain, nicknamed El Tor, which still persists today in developing countries.

From a local disease, cholera became one of the most widespread and deadly diseases of the 19th century, killing an estimated tens of millions of people. In Russia alone, between 1847 and 1851, more than one million people perished of the disease. It killed 150,000 Americans during the second pandemic. Between 1900 and 1920, perhaps eight million people died of cholera in India. Cholera became the first reportable disease in the United States due to the significant effects it had on health. John Snow, in England, was the first to identify the importance of contaminated water in its cause in 1854. Cholera is now no longer considered a pressing health threat in Europe and North America due to filtering and chlorination of water supplies, but still heavily affects populations in developing countries.

In the past, vessels flew a yellow quarantine flag if any crew members or passengers were suffering from cholera. No one aboard a vessel flying a yellow flag would be allowed ashore for an extended period, typically 30 to 40 days. In modern sets of international maritime signal flags, the quarantine flag is yellow and black.

Historically many different claimed remedies have existed in folklore. In the 1854–1855 outbreak in Naples homeopathic Camphor was used according to Hahnemann. While T. J. Ritter's "Mother's Remedies" book lists tomato syrup as a home remedy from northern America. While elecampagne was recommended in the United Kingdom according to William Thomas Fernie

Research

The bacterium was isolated in 1855 by Italian anatomist Filippo Pacini, but its exact nature and his results were not widely known.

Spanish physician Jaume Ferran i Clua developed a cholera vaccine in 1885, the first to immunize humans against a bacterial disease.

Ukrainian bacteriologist Waldemar Haffkine developed a cholera vaccine in July 1892.

One of the major contributions to fighting cholera was made by the physician and pioneer medical scientist John Snow (1813–1858), who in 1854 found a link between cholera and contaminated drinking water. Dr. Snow proposed a microbial origin for epidemic cholera in 1849. In his major "state of the art" review of 1855, he proposed a substantially complete and correct model for the etiology of the disease. In two pioneering epidemiological field studies, he was able to demonstrate human sewage contamination was the most probable disease vector in two major epidemics in London in 1854. His model was not immediately accepted, but it was seen to be the more plausible, as medical microbiology developed over the next 30 years or so.

Cities in developed nations made massive investment in clean water supply and well-separated sewage treatment infrastructures between the mid-1850s and the 1900s. This eliminated the threat of cholera epidemics from the major developed cities in the world. In 1883, Robert Koch identified V. cholerae with a microscope as the bacillus causing the disease.

Robert Allan Phillips, working at the US Naval Medical Research Unit Two in Southeast Asia, evaluated the pathophysiology of the disease using modern laboratory chemistry techniques and developed a protocol for rehydration. His research led the Lasker Foundation to award him its prize in 1967.

Cholera has been a laboratory for the study of evolution of virulence. The province of Bengal in British India was partitioned into West Bengal and East Pakistan in 1947. Prior to partition, both regions had cholera pathogens with similar characteristics. After 1947, India made more progress on public health than East Pakistan (now Bangladesh). As a consequence, the strains of the pathogen that succeeded in India had a greater incentive in the longevity of the host. They have become less virulent than the strains prevailing in Bangladesh. These draw upon the resources of the host population and rapidly kill many victims.

More recently, in 2002, Alam, et al., studied stool samples from patients at the International Centre for Diarrhoeal Disease in Dhaka, Bangladesh. From the various experiments they conducted, the researchers found a correlation between the passage of V. cholerae through the human digestive system and an increased infectivity state. Furthermore, the researchers found the bacterium creates a hyperinfected state where genes that control biosynthesis of amino acids, iron uptake systems, and formation of periplasmic nitrate reductase complexes were induced just before defecation. These induced characteristics allow the cholera vibrios to survive in the "rice water" stools, an environment of limited oxygen and iron, of patients with a cholera infection.

Notable cases

• Tchaikovsky's death has traditionally been attributed to cholera, most probably contracted through drinking contaminated water several days earlier. "Since the water was not boiled and cholera was affecting Saint Petersburg, such a connection is quite plausible ...." Tchaikovsky's mother died of cholera, and his father became sick with cholera at this time but made a full recovery. Some scholars, however, including English musicologist and Tchaikovsky authority David Brown and biographer Anthony Holden, have theorized that his death was a suicide.
• After the 2010 earthquake, an outbreak swept over Haiti, traced to a United Nations base. This marks the worst cholera outbreak in recent history, as well as the best documented cholera outbreak in modern public health.

Other famous people believed to have died of cholera include:

• Sadi Carnot, Physicist, a founder of thermodynamics (d. 1832)
• Charles X, King of France (d. 1836)
• James K. Polk, eleventh president of the United States (d. 1849)
• Carl von Clausewitz, Prussian soldier and German military theorist (d. 1831)
• Maria Agata Szymanowska, Polish pianist and composer (d. 1831)

Society and culture

The World Health Organization recommends focusing on prevention, preparedness, and response to combat the spread of cholera. They also stress the importance of an effective surveillance system. Governments can play a role in all of these areas, and in preventing cholera or indirectly facilitating its spread.

Cholera cases are much less frequent in developed countries where governments have helped to establish water sanitation practices and effective medical treatments. The United States, for example, used to have a severe cholera problem similar to those in some developing countries. There were three large cholera outbreaks in the 1800s, which can be attributed to Vibrio cholerae's spread through interior waterways like the Erie Canal and routes along the Eastern Seaboard. The island of Manhattan in New York City touched the Atlantic Ocean, where cholera collected just off the coast. At this time, New York City did not have as effective a sanitation system as it does today, so cholera was able to spread.

In many developing countries, cholera still reaches its victims through contaminated water sources, and countries without proper sanitation techniques have greater incidence of the disease. Governments can play a role in this. In 2008, for example, under Zimbabwean president Robert Mugabe’s reign, money was diverted from several water treatment plants. These water sanitation plants helped to disperse clean water throughout the country, and their absence resulted in an increase of cholera rate and subsequent deaths. The Haitian government’s inability to provide safe drinking water after the 2010 earthquake led to an increase in cholera cases as well. Similarly, South Africa’s cholera outbreak was exacerbated by the government’s policy of privatizing water programs. The wealthy elite of the country were able to afford safe water while others had to use water from cholera-infected rivers. The ability of government leaders to affects whether cholera is prevented or allowed to spread. It also affects who has access to clean water, as effective government can ensure that everyone has access to safe water, not just the wealthy.

If cholera does begin to spread, government preparedness is crucial. A government’s ability to contain the disease before it extends to other areas can prevent a high death toll and the development of an epidemic or even pandemic. The resources that a government puts into its health care system help to treat cholera victims. Effective disease surveillance can ensure that cholera outbreaks are recognized as soon as possible and dealt with appropriately. Oftentimes, this will allow public health programs to determine and control the cause of the cases, whether it is unsanitary water or seafood that have accumulated a lot of Vibrio cholerae specimens. Another benefit of government surveillance of disease is that it considers how well disease-reduction programs, like new vaccine treatments, are working. If they are not working effectively, new institutions can be created. If the current disease-reduction program is effective, it can be used in other countries to help reduce their incidence of cholera outbreaks. Having an effective surveillance program contributes to a government’s ability to prevent cholera from spreading. In the 2000 in the state of Kerala in India, the Kottayam district was determined to be “cholera-affected.” This pronouncement led to task forces that concentrated on educating citizens with 13,670 information sessions about human health. These task forces promoted the boiling of water to obtain safe water, and provided chlorine and oral rehydration salts. Ultimately, this helped to control the spread of the disease to other areas and minimize deaths. On the other hand, researchers have shown that most of the citizens infected during the 1991 cholera outbreak in Bangladesh lived in rural areas, and were not recognized by the government’s surveillance program. This inhibited physicians’ abilities to detect cholera cases early.

The quality and inclusiveness of a country’s overarching health care system affects the control of cholera cases too. Consider the recent cholera outbreak in Zimbabwe. Zimbabwe used to have one of the strongest public health care systems in Africa. It was one of the African countries least affected by cholera because of its well-organized health care system and effective water sanitation facilities. In recent years, however, there has been a serious decline in the health care system. A lack of resources in Zimbabwe's health care system has contributed to its decline. Zimbabwean doctors, for example, are now faced with shortages of latex gloves. This makes them more susceptible to cholera, and prods them to leave a country where there are already food shortages and decreasing educational standards for their children. The issue of food shortages is a huge problem in the crisis, because the symptoms of cholera are worse when the patient is hungry and doesn’t have proper fluids in their system. Medical professionals are also leaving the country at alarming speed because President Mugabe’s Youth Militia prohibits health professionals from providing medical treatment to political opponents. According to the chairman of the Zimbabwe Doctors for Human Rights group, one doctor in Zimbabwe is expected to care for 12,000 citizens. These factors have contributed to a worsening public-health crisis in Zimbabwe. Bangladesh, which faced a severe cholera outbreak in 1991, also had issues with its health care system. Many cholera victims had a difficult time obtaining medical care and proper treatment, as shown by the fact that just 29% of cholera victims were able to receive treatment from qualified medical professionals. 68% of people affected by the cholera outbreak went to unqualified medical professionals in rural areas for assistance, while others received no help at all. Similarly, South Africa government’s new policy of privatizing water programs contributed to a declining public health care system and an increase in the number of cases and deaths from cholera.

While sanitation practices are important, the way a government responds to cases is also an important factor in the containment or spread of this infectious disease. If the government responds quickly to the epidemic and has readily available vaccines, the country will have a lower cholera death toll. However, one of the biggest problems with such vaccines is affordability. If the government does not help provide vaccines, often only the wealthy will be able to afford them. This is why cholera typically takes a greater toll among developing countries, and on that country’s poor population. The speed with which government leaders respond to cholera outbreaks is also important. The government of Zimbabwe did not request international aid until the crisis was well under way, which may have contributed to a more severe cholera crisis and a higher death toll.

Besides contributing to an effective or declining public health care system and water sanitation treatments, the government in power can have indirect effects on cholera control and the effectiveness of a response to cholera. For example, if other countries have political differences with the current regime, these countries are less likely to give aid. It is believed that foreign countries gave less aid to Zimbabwe than they otherwise would have, because they believed giving the country money was going to prop up the regime of President Robert Mugabe. A country’s government can impact its ability to prevent disease and control its spread. If proper care is not given to water purification, there may be a spike in cholera cases and other health consequences. A speedy government response backed by a fully functioning health care system and financial resources can prevent cholera's spread. This limits cholera's ability to cause death, or at the very least a decline in education, as children are kept out of school to minimize the risk of infection.

See also

• Cholera (food) for the dish named after the disease

References

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45. Blake, PA (1993). "Epidemiology of cholera in the Americas". Gastroenterology clinics of North America. 22 (3): 639–60. PMID 7691740.
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47. "Cholera's seven pandemics". CBC News. October 22, 2010.
48. McNeil, John. Something New Under The Sun:An Environmental History of the Twentieth Century World (The Global Century Series).
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50. .Kelley Lee (2003) "Health impacts of globalization: towards global governance". Palgrave Macmillan. p.131. ISBN 0-333-80254-3
51. Geoffrey A. Hosking (2001). "Russia and the Russians: a history". Harvard University Press. p.9. ISBN 0-674-00473-6
52. Byrne, Joseph Patrick (2008). Encyclopedia of Pestilence, Pandemics, and Plagues: A-M. ABC-CLIO. p. 99. ISBN 0-313-34102-8.
53. J. N. Hays (2005). "Epidemics and pandemics: their impacts on human history". p.347. ISBN 1-85109-658-2
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55. http://www.legatum.sk/en:ahr:bayes-cholera-as-treated-by-dr-rubini-158-10355 The American Homoeopathic Review Vol. 06 No. 11-12, 1866, pages 401-403
56. "Cholera Infantum, Tomatoes Will Relieve". October 13, 2008.
57. http://www.historyofvaccines.org/content/timelines/others#EVT_101034
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Further reading

• Colwell RR (1996). "Global climate and infectious disease: the cholera paradigm". Science. 274 (5295): 2025–31. doi:10.1126/science.274.5295.2025. PMID 8953025. {{cite journal}}: Invalid |ref=harv (help); Unknown parameter |month= ignored (help)
• Drasar, B. S.; Forrest, Bruce D., eds. (1996). Cholera and the ecology of Vibrio cholerae. Springer. p. 355. ISBN 0-412-61220-8. {{cite book}}: Invalid |ref=harv (help)
• Echenberg, Myron (2011) Africa in the Time of Cholera. A History of Pandemics from 1817 to the Present, Cambridge University Press, New York (Paperback) ISBN 978-0-521-18820-3
• Furuque, Shah M.; Nair, G. Balakrish, eds. (2008). Vibrio Cholerae: Genomics and Molecular Biology. Horizon Scientific Press. p. 218. ISBN 1-904455-33-6. {{cite book}}: Invalid |ref=harv (help)
• Gilbert, Pamela K. (2008). "Cholera and Nation: Doctoring the Social Body in Victorian England". SUNY Press. p. 231. ISBN 0-7914-7343-0. {{cite journal}}: Cite journal requires |journal= (help); Invalid |ref=harv (help)
• Henze, Charlotte E. (2011) Disease, Health Care and Government in Late Imperial Russia: Life and Death on the Volga, 1823-1914. Routledge, Oxon, UK 2011. ISBN 9780415547949.
• Jermyn, William S.; O'Shea, Yvonne A.; Quirke, Anne Marie; Boyd, E. Fidelma (2006). "Genomics and the Evolution of Pathogenic Vibrio Cholerae". In Chan, Voon L.; Sherman, Philip M.; Bourke, Billy (eds.). Bacterial genomes and infectious diseases. Humana Press. p. 270. ISBN 1-58829-496-X. {{cite book}}: Invalid |ref=harv (help)
• Johnson, Steven (2006). The Ghost Map: The Story of London's Most Terrifying Epidemic--and How It Changed Science, Cities, and the Modern World. Riverhead Hardcover. ISBN 1-59448-925-4.
• McGrew, Roderick (1985) Encyclopedia of Medical History, brief history pp. 59–64.
• Mintz ED, Guerrant RL (2009). "A lion in our village--the unconscionable tragedy of cholera in Africa". N. Engl. J. Med. 360 (11): 1060–3. doi:10.1056/NEJMp0810559. PMID 19279337. {{cite journal}}: Invalid |ref=harv (help); Unknown parameter |month= ignored (help)
• Pardio Sedas, Violeta T. (2008). "Impact of Climate and Environmental Factors on the Epidemiology of Vibrio choerae in Aquatic Ecosystems". In Hofer, Tobias N. (ed.). Marine Pollution: New Research. Nova Science publishers. p. 448. pp. 221–254. ISBN 1-60456-242-0. {{cite book}}: Invalid |ref=harv (help)
• Ryan, Kenneth J.; Ray, C. George, eds. (2003). Sherris medical microbiology: an introduction to infectious diseases (4th ed.). McGraw-Hill Professional. p. 979. ISBN 0-8385-8529-9. {{cite book}}: Invalid |ref=harv (help)
• Wachsmuth, Kaye; Blake, Paul A.; Olsvik, Ørjan, eds. (1994). Vibrio cholerae and cholera: molecular to global perspectives. ASM Press. p. 465. ISBN 1-55581-067-5. {{cite book}}: Invalid |ref=harv (help)

External links

• Cholera—World Health Organization
• The Attenuation of the Causal Agent of Fowl Cholera, by Louis Pasteur, 1880
• What is Cholera?—Centers for Disease Control and Prevention
• Cholera Epidemic in NYC in 1832 New York Times 15 April 2008
• The Cholera Timebomb in The DRC—slideshow by The First Post

• Cholera
• Biological weapons
• Diarrhea
• Foodborne illnesses
• GI tract disorders
• Intestinal infectious diseases
• Neglected diseases
• Pandemics
• Waterborne diseases