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| The signs and symptoms of acute beryllium pneumonitis usually resolve over several weeks to months, but may be fatal in 10 percent of cases,<ref name=OSHAhealtheffects/> and about 15–20% of cases may progress to CBD.<ref>{{Cite journal|doi=10.1056/NEJM196511252732205|pmid=5847559|year=1965|last1=Hardy|first1=HL|title=Beryllium poisoning--lessons in control of man-made disease|volume=273|issue=22|pages=1188–99|journal=The New England Journal of Medicine}}</ref> | The signs and symptoms of acute beryllium pneumonitis usually resolve over several weeks to months, but may be fatal in 10 percent of cases,<ref name=OSHAhealtheffects/> and about 15–20% of cases may progress to ].<ref>{{Cite journal|doi=10.1056/NEJM196511252732205|pmid=5847559|year=1965|last1=Hardy|first1=HL|title=Beryllium poisoning--lessons in control of man-made disease|volume=273|issue=22|pages=1188–99|journal=The New England Journal of Medicine}}</ref> | ||
| Acute beryllium poisoning approximately doubles the risk of getting lung cancer.<ref name=ntp>National Toxicology Program, Department of Health and Human Services. Report on Carcinogens, Thirteenth Edition </ref> The mechanism by which beryllium is carcinogenic is unclear, but may be due to ionic beryllium binding to nucleic acids; it is not mutagenic.<ref name=ntp/> | Acute beryllium poisoning approximately doubles the risk of getting lung cancer.<ref name=ntp>National Toxicology Program, Department of Health and Human Services. Report on Carcinogens, Thirteenth Edition </ref> The mechanism by which beryllium is carcinogenic is unclear, but may be due to ionic beryllium binding to nucleic acids; it is not mutagenic.<ref name=ntp/> | ||
Revision as of 08:15, 3 December 2016
Medical condition
| Acute beryllium poisoning | |
|---|---|
| Specialty | Emergency medicine  |
Acute beryllium poisoning is acute chemical pneumonia resulting from the toxic effect of beryllium in its elemental form or in various chemical compounds, and is distinct from berylliosis (also called chronic beryllium disease). After occupational safety procedures were put into place following the realization that the metal caused berylliosis around 1950, acute beryllium poisoning became extremely rare.
Risk factors
Acute beryllium poisoning is an occupational disease. Relevant occupations are those where beryllium is mined, processed or converted into metal alloys, or where machining of metals containing beryllium or recycling of scrap alloys occurs.
Signs and symptoms
Generally associated with exposure to beryllium levels at or above 100 μg/m, it produces severe cough, sore nose and throat, weight loss, labored breathing, anorexia, and increased fatigue.
In addition to beryllium's toxicity when inhaled, when brought into contact with skin at relatively low doses, beryllium can cause local irritation and contact dermatitis, and contact with skin that has been scraped or cut may cause rashes or ulcers. Beryllium dust or powder can irritate the eyes.
Management
Therapy is supportive and includes removal from further beryllium exposure. For very severe cases mechanical ventilation may be required.
Prognosis
The signs and symptoms of acute beryllium pneumonitis usually resolve over several weeks to months, but may be fatal in 10 percent of cases, and about 15–20% of cases may progress to CBD.
Acute beryllium poisoning approximately doubles the risk of getting lung cancer. The mechanism by which beryllium is carcinogenic is unclear, but may be due to ionic beryllium binding to nucleic acids; it is not mutagenic.
History
Acute beryllium disease was first reported in Europe in 1933 and in the United States in 1943.
References
- ^ OSHA Beryllium Health Effects Page accessed March 29, 2016
- ATSDR. ToxGuide for Beryllium September 2002
- Agency for Toxic Substances and Disease Registry. September 2002 Toxicological Profile: Beryllium. See also 2009 Addendum
- Agency for Toxic Substances and Disease Registry via the CDC. TOX FAQs: Beryllium Page last reviewed: March 3, 2011. Page last updated: June 3, 2015
- NIOSH International Chemical Safety Cards: Beryllium Page last reviewed: July 22, 2015. Page last updated: July 1, 2014
- Newman, LS for the Merck Manual. Beryllium Disease Last full review/revision May 2014
- Hardy, HL (1965). "Beryllium poisoning--lessons in control of man-made disease". The New England Journal of Medicine. 273 (22): 1188–99. doi:10.1056/NEJM196511252732205. PMID 5847559.
- ^ National Toxicology Program, Department of Health and Human Services. Report on Carcinogens, Thirteenth Edition Beryllium and Beryllium Compounds
- Lang, Leslie (June–July 1994). "Beryllium: A Chronic Problem". Environmental Health Perspectives. 102 (6–7): 526–31. doi:10.1289/ehp.94102526. PMC 1569745. PMID 9679108.
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This article incorporates public domain material from Beryllium. Occupational Safety and Health Administration. Retrieved 28 March 2016.
This article incorporates public domain material from ToxGuide for Beryllium (PDF). United States Department of Health and Human Services.