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| '''Levofloxacin''' is an advanced generation ] ], marketed by ] under the trade name '''Levaquin''' in the US. In Europe, it is marketed by Sanofi-Aventis under the trade name of "Tavanic", and in Asia it is marketed by Daiichi under the trade name of Cravit. Levofloxacin |
'''Levofloxacin''' is an advanced generation ] ], marketed by ] under the trade name '''Levaquin''' in the US. In Europe, it is marketed by Sanofi-Aventis under the trade name of "Tavanic", and in Asia it is marketed by Daiichi under the trade name of Cravit. Levofloxacin was launched in the Japanese market in 1993, and thus has had more than 12 years of testing in efficacy and safety globally. Chemically, levofloxacin is the S-] (L-]) of ], and has approximately twice the potency of ofloxacin. | ||
| Levofloxacin is effective against a number of ] and ] ]. Because of its broad spectrum of action, levofloxacin is frequently prescribed empirically for a wide range of infections (e.g. ], ]) before the specific causal organism is known. If the causal organism is identified, levofloxacin may be discontinued and the patient may be switched to an antibiotic with a narrower spectrum of activity. Levofloxacin is currently the only respiratory fluoroquinolone approved by the US FDA for the treatment of ]. | Levofloxacin is effective against a number of ] and ] ]. Because of its broad spectrum of action, levofloxacin is frequently prescribed empirically for a wide range of infections (e.g. ], ]) before the specific causal organism is known. If the causal organism is identified, levofloxacin may be discontinued and the patient may be switched to an antibiotic with a narrower spectrum of activity. Levofloxacin is currently the only respiratory fluoroquinolone approved by the US FDA for the treatment of ]. | ||
Revision as of 22:19, 22 November 2006
Pharmaceutical compound | |
| Clinical data | |
|---|---|
| Pregnancy category |
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| Routes of administration | Oral, IV, Ophthalmic |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 99% |
| Protein binding | 24 to 38% |
| Metabolism | Renal |
| Elimination half-life | 6 to 8 hours |
| Excretion | Urinary |
| Identifiers | |
IUPAC name
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.115.581  |
| Chemical and physical data | |
| Formula | C18H20FN3O4 |
| Molar mass | 361.368 g/mol g·mol |
Levofloxacin is an advanced generation fluoroquinolone antibiotic, marketed by Ortho-McNeil under the trade name Levaquin in the US. In Europe, it is marketed by Sanofi-Aventis under the trade name of "Tavanic", and in Asia it is marketed by Daiichi under the trade name of Cravit. Levofloxacin was launched in the Japanese market in 1993, and thus has had more than 12 years of testing in efficacy and safety globally. Chemically, levofloxacin is the S-enantiomer (L-isomer) of ofloxacin, and has approximately twice the potency of ofloxacin.
Levofloxacin is effective against a number of gram-positive and gram-negative bacteria. Because of its broad spectrum of action, levofloxacin is frequently prescribed empirically for a wide range of infections (e.g. pneumonia, urinary tract infection) before the specific causal organism is known. If the causal organism is identified, levofloxacin may be discontinued and the patient may be switched to an antibiotic with a narrower spectrum of activity. Levofloxacin is currently the only respiratory fluoroquinolone approved by the US FDA for the treatment of nosocomial pneumonia.
As approved by the US FDA
Gram-positive bacteria
- Enterococcus faecalis (many strains are only moderately susceptible)
- Staphylococcus aureus (methicillin-susceptible strains)
- Staphylococcus epidermidis (methicillin-susceptible strains)
- Staphylococcus saprophyticus
- Streptococcus pneumoniae (including Multidrug-resistant strains, MDRSP)
- Streptococcus pyogenes
Gram-negative bacteria
- Enterobacter cloacae
- Klebsiella pneumoniae
- Pseudomonas aeruginosa
- Escherichia coli
- Legionella pneumophila
- Serratia marcescens
- Haemophilus influenzae
- Moraxella catarrhalis
- Haemophilus parainfluenzae
- Proteus mirabilis
- Campylobacter
Other
- More bacterial coverage is available as per presribing information for levofloxacin in Japan (Cravit)
Some information extracted from Levaquin Prescribing information.
| Antibacterials that inhibit nucleic acid (J01E, J01M) | |||||||||||||||||
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| Antifolates (inhibit bacterial purine metabolism, thereby inhibiting DNA and RNA synthesis) |
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| Quinolones (inhibit bacterial topoisomerase and/or DNA gyrase, thereby inhibiting DNA replication) |
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| Anaerobic DNA inhibitors |
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| RNA synthesis |
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- "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.