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Evolution in its broadest sense, is the accumulation of change. In this sense, anything in which changes accumulate, evolves. This is true of culture, language, computer software, technology, knowledge, automation, and so on. A quick web search for information about the evolution of any such thing should provide plenty of reference material.

Probably the most well known type of evolution, accumulation of hereditary modification, also known as descent with modification, causes the accumulation of change in the inherited characteristics of biological populations over successive generations. Such evolutionary processes give rise to diversity at every level of biological organisation, including the biodiversity of species, individual organisms and molecules such as DNA and proteins.

All life on Earth is descended from a last universal ancestor that lived approximately 3.8-3.5 billion years ago. Repeated speciation and the divergence of life can be inferred from shared sets of biochemical and morphological traits, or by sequencing shared DNA sequences. These homologous traits and sequences are more similar among species that share a more recent common ancestor, and can be used to reconstruct evolutionary histories, using both existing species and the fossil record. Existing patterns of biodiversity have been shaped both by speciation and by extinction.

Charles Darwin was the first to formulate a scientific argument for the theory of evolution by means of natural selection. Evolution by natural selection is a process inferred from three facts about populations: 1) more offspring are produced than can possibly survive, 2) traits vary among individuals, leading to different rates of survival and reproduction, and 3) trait differences are heritable. Thus, when members of a population die they are replaced by the progeny of parents better adapted to survive and reproduce in the biophysical environment in which natural selection takes place. This process creates and preserves traits that are seemingly fitted for the functional roles they perform. Natural selection is the only known cause of adaptation, but not the only known cause of evolution. Other, nonadaptive causes of microevolution include mutation and genetic drift.

In the early 20th century, genetics was integrated with Darwin's theory of evolution by natural selection through the discipline of population genetics. The importance of natural selection as a cause of evolution was accepted into other branches of biology. Moreover, previously held notions about evolution, such as orthogenesis and other idea of "progress" within the largest-scale trends in evolution became obsolete. Scientists continue to study various aspects of evolutionary biology by forming and testing hypotheses, constructing scientific theories, using observational data, and performing experiments in both the field and the laboratory. Biologists agree that descent with modification is one of the most reliably established of all the facts and theories in science. Discoveries in evolutionary biology have made a significant impact not just within the traditional branches of biology, but also in other academic disciplines (e.g., anthropology and psychology) and on society at large.

History of evolutionary thought

The proposal that one type of animal could descend from an animal of another type goes back to some of the first pre-Socratic Greek philosophers, such as Anaximander and Empedocles. Such proposals survived into Roman times. The poet and philosopher Lucretius followed Empedocles in his masterwork De rerum natura (On the Nature of Things). In contrast to these materialistic views, Aristotle understood all natural things, not only living things, as being imperfect actualisations of different fixed natural possibilities, known as "forms", "ideas", or (in Latin translations) "species". This was part of his teleological understanding of nature in which all things have an intended role to play in a divine cosmic order. Variations of this idea became the standard understanding of the Middle Ages, and were integrated into Christian learning, but Aristotle did not demand that real types of animals always corresponded one-for-one with exact metaphysical forms, and specifically gave examples of how new types of living things could come to be.

In the 17th century the new method of modern science rejected Aristotle's approach, and sought explanations of natural phenomena in terms of physical laws which were the same for all visible things, and did not need to assume any fixed natural categories, nor any divine cosmic order. But this new approach was slow to take root in the biological sciences, which became the last bastion of the concept of fixed natural types. John Ray used one of the previously more general terms for fixed natural types, "species", to apply to animal and plant types, but he strictly identified each type of living thing as a species, and proposed that each species can be defined by the features that perpetuate themselves each generation. These species were designed by God, but showing differences caused by local conditions. The biological classification introduced by Carolus Linnaeus in 1735 also viewed species as fixed according to a divine plan.

Other naturalists of this time speculated on evolutionary change of species over time according to natural laws. Maupertuis wrote in 1751 of natural modifications occurring during reproduction and accumulating over many generations to produce new species. Buffon suggested that species could degenerate into different organisms, and Erasmus Darwin proposed that all warm-blooded animals could have descended from a single micro-organism (or "filament"). The first full-fledged evolutionary scheme was Lamarck's "transmutation" theory of 1809 which envisaged spontaneous generation continually producing simple forms of life that developed greater complexity in parallel lineages with an inherent progressive tendency, and that on a local level these lineages adapted to the environment by inheriting changes caused by use or disuse in parents. (The latter process was later called Lamarckism.) These ideas were condemned by established naturalists as speculation lacking empirical support. In particular, Georges Cuvier insisted that species were unrelated and fixed, their similarities reflecting divine design for functional needs. In the meantime, Ray's ideas of benevolent design had been developed by William Paley into the Natural Theology or Evidences of the Existence and Attributes of the Deity (1802) which proposed complex adaptations as evidence of divine design, and was admired by Charles Darwin.

The critical break from the concept of fixed species in biology began with the theory of evolution by natural selection, which was formulated by Charles Darwin. Partly influenced by An Essay on the Principle of Population by Thomas Robert Malthus, Darwin noted that population growth would lead to a "struggle for existence" where favorable variations could prevail as others perished. Each generation, many offspring fail to survive to an age of reproduction because of limited resources. This could explain the diversity of animals and plants from a common ancestry through the working of natural laws working the same for all types of thing. Darwin was developing his theory of "natural selection" from 1838 onwards until Alfred Russel Wallace sent him a similar theory in 1858. Both men presented their separate papers to the Linnean Society of London. At the end of 1859, Darwin's publication of On the Origin of Species explained natural selection in detail and in a way that led to an increasingly wide acceptance of Darwinian evolution. Thomas Henry Huxley applied Darwin's ideas to humans, using paleontology and comparative anatomy to provide strong evidence that humans and apes shared a common ancestry. Some were disturbed by this since it implied that humans did not have a special place in the universe.

Precise mechanisms of reproductive heritability and the origin of new traits remained a mystery. Towards this end, Darwin developed his provisional theory of pangenesis. In 1865, Gregor Mendel reported that traits were inherited in a predictable manner through the independent assortment and segregation of elements (later known as genes). Mendel's laws of inheritance eventually supplanted most of Darwin's pangenesis theory. August Weismann made the important distinction between germ cells (sperm and eggs) and somatic cells of the body, demonstrating that heredity passes through the germ line only. Hugo de Vries connected Darwin's pangenesis theory to Weismann's germ/soma cell distinction and proposed that Darwin's pangenes were concentrated in the cell nucleus and when expressed they could move into the cytoplasm to change the cells structure. De Vries was also one of the researchers who made Mendel's work well-known, believing that Mendelian traits corresponded to the transfer of heritable variations along the germline. To explain how new variants originate, De Vries developed a mutation theory that led to a temporary rift between those who accepted Darwinian evolution and biometricians who allied with de Vries. At the turn of the 20th century, pioneers in the field of population genetics, such as J.B.S. Haldane, Sewall Wright, and Ronald Fisher, set the foundations of evolution onto a robust statistical philosophy. The false contradiction between Darwin's theory, genetic mutations, and Mendelian inheritance was thus reconciled.

In the 1920s and 1930s a modern evolutionary synthesis connected natural selection, mutation theory, and Mendelian inheritance into a unified theory that applied generally to any branch of biology. The modern synthesis was able to explain patterns observed across species in populations, through fossil transitions in palaeontology, and even complex cellular mechanisms in developmental biology. The publication of the structure of DNA by James Watson and Francis Crick in 1953 demonstrated a physical basis for inheritance. Molecular biology improved our understanding of the relationship between genotype and phenotype. Advancements were also made in phylogenetic systematics, mapping the transition of traits into a comparative and testable framework through the publication and use of evolutionary trees. In 1973, evolutionary biologist Theodosius Dobzhansky penned that "nothing in biology makes sense except in the light of evolution", because it has brought to light the relations of what first seemed disjointed facts in natural history into a coherent explanatory body of knowledge that describes and predicts many observable facts about life on this planet.

Since then, the modern synthesis has been further extended to explain biological phenomena across the full and integrative scale of the biological hierarchy, from genes to species. This extension has been dubbed "evo-devo".

Heredity

Evolution in organisms occurs through changes in heritable traits – particular characteristics of an organism. In humans, for example, eye colour is an inherited characteristic and an individual might inherit the "brown-eye trait" from one of their parents. Inherited traits are controlled by genes and the complete set of genes within an organism's genome is called its genotype.

The complete set of observable traits that make up the structure and behaviour of an organism is called its phenotype. These traits come from the interaction of its genotype with the environment. As a result, many aspects of an organism's phenotype are not inherited. For example, suntanned skin comes from the interaction between a person's genotype and sunlight; thus, suntans are not passed on to people's children. However, some people tan more easily than others, due to differences in their genotype; a striking example are people with the inherited trait of albinism, who do not tan at all and are very sensitive to sunburn.

Heritable traits are passed from one generation to the next via DNA, a molecule that encodes genetic information. DNA is a long polymer composed of four types of bases. The sequence of bases along a particular DNA molecule specify the genetic information, in a manner similar to a sequence of letters spelling out a sentence. Before a cell divides, the DNA is copied, so that each of the resulting two cells will inherit the DNA sequence. Portions of a DNA molecule that specify a single functional unit are called genes; different genes have different sequences of bases. Within cells, the long strands of DNA form condensed structures called chromosomes. The specific location of a DNA sequence within a chromosome is known as a locus. If the DNA sequence at a locus varies between individuals, the different forms of this sequence are called alleles. DNA sequences can change through mutations, producing new alleles. If a mutation occurs within a gene, the new allele may affect the trait that the gene controls, altering the phenotype of the organism. However, while this simple correspondence between an allele and a trait works in some cases, most traits are more complex and are controlled by multiple interacting genes.

Recent findings have confirmed important examples of heritable changes that cannot be explained by changes to the sequence of nucleotides in the DNA. These phenomena are classed as epigenetic inheritance systems. DNA methylation marking chromatin, self-sustaining metabolic loops, gene silencing by RNA interference and the three-dimensional conformation of proteins (such as prions) are areas where epigenetic inheritance systems have been discovered at the organismic level. Developmental biologists suggest that complex interactions in genetic networks and communication among cells can lead to heritable variations that may underlay some of the mechanics in developmental plasticity and canalization. Heritability may also occur at even larger scales. For example, ecological inheritance through the process of niche construction is defined by the regular and repeated activities of organisms in their environment. This generates a legacy of effects that modify and feed back into the selection regime of subsequent generations. Descendants inherit genes plus environmental characteristics generated by the ecological actions of ancestors. Other examples of heritability in evolution that are not under the direct control of genes include the inheritance of cultural traits and symbiogenesis.

Variation

An individual organism's phenotype results from both its genotype and the influence from the environment it has lived in. A substantial part of the variation in phenotypes in a population is caused by the differences between their genotypes. The modern evolutionary synthesis defines evolution as the change over time in this genetic variation. The frequency of one particular allele will become more or less prevalent relative to other forms of that gene. Variation disappears when a new allele reaches the point of fixation — when it either disappears from the population or replaces the ancestral allele entirely.

Natural selection will only cause evolution if there is enough genetic variation in a population. Before the discovery of Mendelian genetics, one common hypothesis was blending inheritance. But with blending inheritance, genetic variance would be rapidly lost, making evolution by natural selection implausible. The Hardy-Weinberg principle provides the solution to how variation is maintained in a population with Mendelian inheritance. The frequencies of alleles (variations in a gene) will remain constant in the absence of selection, mutation, migration and genetic drift.

Variation comes from mutations in genetic material, reshuffling of genes through sexual reproduction and migration between populations (gene flow). Despite the constant introduction of new variation through mutation and gene flow, most of the genome of a species is identical in all individuals of that species. However, even relatively small differences in genotype can lead to dramatic differences in phenotype: for example, chimpanzees and humans differ in only about 5% of their genomes.

Mutation

Mutations are changes in the DNA sequence of a cell's genome. When mutations occur, they can either have no effect, alter the product of a gene, or prevent the gene from functioning. Based on studies in the fly Drosophila melanogaster, it has been suggested that if a mutation changes a protein produced by a gene, this will probably be harmful, with about 70% of these mutations having damaging effects, and the remainder being either neutral or weakly beneficial.

Mutations can involve large sections of a chromosome becoming duplicated (usually by genetic recombination), which can introduce extra copies of a gene into a genome. Extra copies of genes are a major source of the raw material needed for new genes to evolve. This is important because most new genes evolve within gene families from pre-existing genes that share common ancestors. For example, the human eye uses four genes to make structures that sense light: three for colour vision and one for night vision; all four are descended from a single ancestral gene.

New genes can be generated from an ancestral gene when a duplicate copy mutates and acquires a new function. This process is easier once a gene has been duplicated because it increases the redundancy of the system; one gene in the pair can acquire a new function while the other copy continues to perform its original function. Other types of mutations can even generate entirely new genes from previously noncoding DNA.

The generation of new genes can also involve small parts of several genes being duplicated, with these fragments then recombining to form new combinations with new functions. When new genes are assembled from shuffling pre-existing parts, domains act as modules with simple independent functions, which can be mixed together to produce new combinations with new and complex functions. For example, polyketide synthases are large enzymes that make antibiotics; they contain up to one hundred independent domains that each catalyse one step in the overall process, like a step in an assembly line.

Sex and recombination

In asexual organisms, genes are inherited together, or linked, as they cannot mix with genes of other organisms during reproduction. In contrast, the offspring of sexual organisms contain random mixtures of their parents' chromosomes that are produced through independent assortment. In a related process called homologous recombination, sexual organisms exchange DNA between two matching chromosomes. Recombination and reassortment do not alter allele frequencies, but instead change which alleles are associated with each other, producing offspring with new combinations of alleles. Sex usually increases genetic variation and may increase the rate of evolution.

Gene flow

Gene flow is the exchange of genes between populations and between species. It can therefore be a source of variation that is new to a population or to a species. Gene flow can be caused by the movement of individuals between separate populations of organisms, as might be caused by the movement of mice between inland and coastal populations, or the movement of pollen between heavy metal tolerant and heavy metal sensitive populations of grasses.

Gene transfer between species includes the formation of hybrid organisms and horizontal gene transfer. Horizontal gene transfer is the transfer of genetic material from one organism to another organism that is not its offspring; this is most common among bacteria. In medicine, this contributes to the spread of antibiotic resistance, as when one bacteria acquires resistance genes it can rapidly transfer them to other species. Horizontal transfer of genes from bacteria to eukaryotes such as the yeast Saccharomyces cerevisiae and the adzuki bean beetle Callosobruchus chinensis has occurred. An example of larger-scale transfers are the eukaryotic bdelloid rotifers, which have received a range of genes from bacteria, fungi and plants. Viruses can also carry DNA between organisms, allowing transfer of genes even across biological domains.

Large-scale gene transfer has also occurred between the ancestors of eukaryotic cells and bacteria, during the acquisition of chloroplasts and mitochondria. It is possible that eukaryotes themselves originated from horizontal gene transfers between bacteria and archaea.

Mechanisms

From a Neo-Darwinian perspective, evolution occurs when there are changes in the frequencies of alleles within a population of interbreeding organisms. For example, the allele for black colour in a population of moths becoming more common. Mechanisms that can lead to changes in allele frequencies include natural selection, genetic drift, genetic hitchhiking, mutation and gene flow.

Natural selection

Evolution by means of natural selection is the process by which genetic mutations that enhance reproduction become and remain more common in successive generations of a population. It has often been called a "self-evident" mechanism because it necessarily follows from three simple facts:

• Heritable variation exists within populations of organisms.
• Organisms produce more progeny than can survive.
• These offspring vary in their ability to survive and reproduce.

These conditions produce competition between organisms for survival and reproduction. Consequently, organisms with traits that give them an advantage over their competitors are more likely to pass on their traits on to the next generation than those with traits that do not confer an advantage.

The central concept of natural selection is the evolutionary fitness of an organism. Fitness is measured by an organism's ability to survive and reproduce, which determines the size of its genetic contribution to the next generation. However, fitness is not the same as the total number of offspring: instead fitness is indicated by the proportion of subsequent generations that carry an organism's genes. For example, if an organism could survive well and reproduce rapidly, but its offspring were all too small and weak to survive, this organism would make little genetic contribution to future generations and would thus have low fitness.

If an allele increases fitness more than the other alleles of that gene, then with each generation this allele will become more common within the population. These traits are said to be "selected for". Examples of traits that can increase fitness are enhanced survival and increased fecundity. Conversely, the lower fitness caused by having a less beneficial or deleterious allele results in this allele becoming rarer — they are "selected against". Importantly, the fitness of an allele is not a fixed characteristic; if the environment changes, previously neutral or harmful traits may become beneficial and previously beneficial traits become harmful. However, even if the direction of selection does reverse in this way, traits that were lost in the past may not re-evolve in an identical form (see Dollo's law).

Natural selection within a population for a trait that can vary across a range of values, such as height, can be categorised into three different types. The first is directional selection, which is a shift in the average value of a trait over time — for example, organisms slowly getting taller. Secondly, disruptive selection is selection for extreme trait values and often results in two different values becoming most common, with selection against the average value. This would be when either short or tall organisms had an advantage, but not those of medium height. Finally, in stabilizing selection there is selection against extreme trait values on both ends, which causes a decrease in variance around the average value and less diversity. This would, for example, cause organisms to slowly become all the same height.

A special case of natural selection is sexual selection, which is selection for any trait that increases mating success by increasing the attractiveness of an organism to potential mates. Traits that evolved through sexual selection are particularly prominent among males of several animal species. Although sexually favoured, traits such as cumbersome antlers, mating calls, large body size and bright colours often attract predation, which compromises the survival of individual males. This survival disadvantage is balanced by higher reproductive success in males that show these hard to fake, sexually selected traits.

Natural selection most generally makes nature the measure against which individuals and individual traits, are more or less likely to survive. "Nature" in this sense refers to an ecosystem, that is, a system in which organisms interact with every other element, physical as well as biological, in their local environment. Eugene Odum, a founder of ecology, defined an ecosystem as: "Any unit that includes all of the organisms...in a given area interacting with the physical environment so that a flow of energy leads to clearly defined trophic structure, biotic diversity and material cycles (ie: exchange of materials between living and nonliving parts) within the system." Each population within an ecosystem occupies a distinct niche, or position, with distinct relationships to other parts of the system. These relationships involve the life history of the organism, its position in the food chain and its geographic range. This broad understanding of nature enables scientists to delineate specific forces which, together, comprise natural selection.

Natural selection can act at different levels of organisation, such as genes, cells, individual organisms, groups of organisms and species. Selection can act at multiple levels simultaneously. An example of selection occurring below the level of the individual organism are genes called transposons, which can replicate and spread throughout a genome. Selection at a level above the individual, such as group selection, may allow the evolution of co-operation, as discussed below.

Biased mutation

In addition to being a major source of variation, mutation may also function as a mechanism of evolution when there are different probabilities at the molecular level for different mutations to occur, a process known as mutation bias. If two genotypes, for example one with the nucleotide G and another with the nucleotide A in the same position, have the same fitness, but mutation from G to A happens more often than mutation from A to G, then genotypes with A will tend to evolve. Different insertion vs. deletion mutation biases in different taxa can lead to the evolution of different genome sizes. Developmental or mutational biases have also been observed in morphological evolution. For example, according to the phenotype-first theory of evolution, mutations can eventually cause the genetic assimilation of traits that were previously induced by the environment.

Mutation bias effects are superimposed on other processes. If selection would favor either one out of two mutations, but there is no extra advantage to having both, then the mutation that occurs the most frequently is the one that is most likely to become fixed in a population. Mutations leading to the loss of function of a gene are much more common than mutations that produce a new, fully functional gene. Most loss of function mutations are selected against. But when selection is weak, mutation bias towards loss of function can affect evolution. For example, pigments are no longer useful when animals live in the darkness of caves, and tend to be lost. This kind of loss of function can occur because of mutation bias, and/or because the function had a cost, and once the benefit of the function disappeared, natural selection leads to the loss. Loss of sporulation ability in a bacterium during laboratory evolution appears to have been caused by mutation bias, rather than natural selection against the cost of maintaining sporulation ability. When there is no selection for loss of function, the speed at which loss evolves depends more on the mutation rate than it does on the effective population size, indicating that it is driven more by mutation bias than by genetic drift.

Genetic drift

Genetic drift is the change in allele frequency from one generation to the next that occurs because alleles are subject to sampling error. As a result, when selective forces are absent or relatively weak, allele frequencies tend to "drift" upward or downward randomly (in a random walk). This drift halts when an allele eventually becomes fixed, either by disappearing from the population, or replacing the other alleles entirely. Genetic drift may therefore eliminate some alleles from a population due to chance alone. Even in the absence of selective forces, genetic drift can cause two separate populations that began with the same genetic structure to drift apart into two divergent populations with different sets of alleles.

It is usually difficult to measure the relative importance of selection and neutral processes, including drift. The comparative importance of adaptive and non-adaptive forces in driving evolutionary change is an area of current research.

The neutral theory of molecular evolution proposed that most evolutionary changes are the result of the fixation of neutral mutations by genetic drift. Hence, in this model, most genetic changes in a population are the result of constant mutation pressure and genetic drift. This form of the neutral theory is now largely abandoned, since it does not seem to fit the genetic variation seen in nature. However, a more recent and better-supported version of this model is the nearly neutral theory, where a mutation that would be neutral in a small population is not necessarily neutral in a large population. Other alternative theories propose that genetic drift is dwarfed by other stochastic forces in evolution, such as genetic hitchhiking, also known as genetic draft.

The time for a neutral allele to become fixed by genetic drift depends on population size, with fixation occurring more rapidly in smaller populations. The number of individuals in a population is not critical, but instead a measure known as the effective population size. The effective population is usually smaller than the total population since it takes into account factors such as the level of inbreeding and the stage of the lifecycle in which the population is the smallest. The effective population size may not be the same for every gene in the same population.

Genetic hitchhiking

Recombination allows alleles on the same strand of DNA to become separated. However, the rate of recombination is low (approximately two events per chromosome per generation). As a result, genes close together on a chromosome may not always be shuffled away from each other and genes that are close together tend to be inherited together, a phenomenon known as linkage. This tendency is measured by finding how often two alleles occur together on a single chromosome compared to expectations, which is called their linkage disequilibrium. A set of alleles that is usually inherited in a group is called a haplotype. This can be important when one allele in a particular haplotype is strongly beneficial: natural selection can drive a selective sweep that will also cause the other alleles in the haplotype to become more common in the population; this effect is called genetic hitchhiking or genetic draft. Genetic draft caused by the fact that some neutral genes are genetically linked to others that are under selection can be partially captured by an appropriate effective population size.

Gene flow

Gene flow involves the exchange of genes between populations and between species. The presence or absence of gene flow fundamentally changes the course of evolution. Due to the complexity of organisms, any two completely isolated populations will eventually evolve genetic incompatibilities through neutral processes, as in the Bateson-Dobzhansky-Muller model, even if both populations remain essentially identical in terms of their adaptation to the environment.

If genetic differentiation between populations develops, gene flow between populations can introduce traits or alleles which are disadvantageous in the local population and this may lead to organisms within these populations evolving mechanisms that prevent mating with genetically distant populations, eventually resulting in the appearance of new species. Thus, exchange of genetic information between individuals is fundamentally important for the development of the biological species concept (BSC).

During the development of the modern synthesis, Sewall Wright developed his shifting balance theory, which regarded gene flow between partially isolated populations as an important aspect of adaptive evolution. However, recently there has been substantial criticism of the importance of the shifting balance theory.

Outcomes

Evolution influences every aspect of the form and behaviour of organisms. Most prominent are the specific behavioural and physical adaptations that are the outcome of natural selection. These adaptations increase fitness by aiding activities such as finding food, avoiding predators or attracting mates. Organisms can also respond to selection by co-operating with each other, usually by aiding their relatives or engaging in mutually beneficial symbiosis. In the longer term, evolution produces new species through splitting ancestral populations of organisms into new groups that cannot or will not interbreed.

These outcomes of evolution are distinguished based on scale as macroevolution versus microevolution. Macroevolution refers to evolution that occurs at or above the level of species, in particular speciation and extinction; whereas microevolution refers to smaller evolutionary changes within a species or population, in particular shifts in gene frequency and adaptation. In general, macroevolution is regarded as the outcome of long periods of microevolution. Thus, the distinction between micro- and macroevolution is not a fundamental one – the difference is simply the time involved. However, in macroevolution, the traits of the entire species may be important. For instance, a large amount of variation among individuals allows a species to rapidly adapt to new habitats, lessening the chance of it going extinct, while a wide geographic range increases the chance of speciation, by making it more likely that part of the population will become isolated. In this sense, microevolution and macroevolution might involve selection at different levels – with microevolution acting on genes and organisms, versus macroevolutionary processes such as species selection acting on entire species and affecting their rates of speciation and extinction.

A common misconception is that evolution has goals or long-term plans; realistically however, evolution has no long-term goal and does not necessarily produce greater complexity. Although complex species have evolved, they occur as a side effect of the overall number of organisms increasing and simple forms of life still remain more common in the biosphere. For example, the overwhelming majority of species are microscopic prokaryotes, which form about half the world's biomass despite their small size, and constitute the vast majority of Earth's biodiversity. Simple organisms have therefore been the dominant form of life on Earth throughout its history and continue to be the main form of life up to the present day, with complex life only appearing more diverse because it is more noticeable. Indeed, the evolution of microorganisms is particularly important to modern evolutionary research, since their rapid reproduction allows the study of experimental evolution and the observation of evolution and adaptation in real time.

Adaptation

Adaptation is the process that makes organisms better suited to their habitat. Also, the term adaptation may refer to a trait that is important for an organism's survival. For example, the adaptation of horses' teeth to the grinding of grass. By using the term adaptation for the evolutionary process and adaptive trait for the product (the bodily part or function), the two senses of the word may be distinguished. Adaptations are produced by natural selection. The following definitions are due to Theodosius Dobzhansky.

1. Adaptation is the evolutionary process whereby an organism becomes better able to live in its habitat or habitats.
2. Adaptedness is the state of being adapted: the degree to which an organism is able to live and reproduce in a given set of habitats.
3. An adaptive trait is an aspect of the developmental pattern of the organism which enables or enhances the probability of that organism surviving and reproducing.

Adaptation may cause either the gain of a new feature, or the loss of an ancestral feature. An example that shows both types of change is bacterial adaptation to antibiotic selection, with genetic changes causing antibiotic resistance by both modifying the target of the drug, or increasing the activity of transporters that pump the drug out of the cell. Other striking examples are the bacteria Escherichia coli evolving the ability to use citric acid as a nutrient in a long-term laboratory experiment, Flavobacterium evolving a novel enzyme that allows these bacteria to grow on the by-products of nylon manufacturing, and the soil bacterium Sphingobium evolving an entirely new metabolic pathway that degrades the synthetic pesticide pentachlorophenol. An interesting but still controversial idea is that some adaptations might increase the ability of organisms to generate genetic diversity and adapt by natural selection (increasing organisms' evolvability).

Adaptation occurs through the gradual modification of existing structures. Consequently, structures with similar internal organisation may have different functions in related organisms. This is the result of a single ancestral structure being adapted to function in different ways. The bones within bat wings, for example, are very similar to those in mice feet and primate hands, due to the descent of all these structures from a common mammalian ancestor. However, since all living organisms are related to some extent, even organs that appear to have little or no structural similarity, such as arthropod, squid and vertebrate eyes, or the limbs and wings of arthropods and vertebrates, can depend on a common set of homologous genes that control their assembly and function; this is called deep homology.

During evolution, some structures may lose their original function and become vestigial structures. Such structures may have little or no function in a current species, yet have a clear function in ancestral species, or other closely related species. Examples include pseudogenes, the non-functional remains of eyes in blind cave-dwelling fish, wings in flightless birds, and the presence of hip bones in whales and snakes. Examples of vestigial structures in humans include wisdom teeth, the coccyx, the vermiform appendix, and other behavioural vestiges such as goose bumps and primitive reflexes.

However, many traits that appear to be simple adaptations are in fact exaptations: structures originally adapted for one function, but which coincidentally became somewhat useful for some other function in the process. One example is the African lizard Holaspis guentheri, which developed an extremely flat head for hiding in crevices, as can be seen by looking at its near relatives. However, in this species, the head has become so flattened that it assists in gliding from tree to tree—an exaptation. Within cells, molecular machines such as the bacterial flagella and protein sorting machinery evolved by the recruitment of several pre-existing proteins that previously had different functions. Another example is the recruitment of enzymes from glycolysis and xenobiotic metabolism to serve as structural proteins called crystallins within the lenses of organisms' eyes.

An area of current investigation in evolutionary developmental biology is the developmental basis of adaptations and exaptations. This research addresses the origin and evolution of embryonic development and how modifications of development and developmental processes produce novel features. These studies have shown that evolution can alter development to produce new structures, such as embryonic bone structures that develop into the jaw in other animals instead forming part of the middle ear in mammals. It is also possible for structures that have been lost in evolution to reappear due to changes in developmental genes, such as a mutation in chickens causing embryos to grow teeth similar to those of crocodiles. It is now becoming clear that most alterations in the form of organisms are due to changes in a small set of conserved genes.

Co-evolution

Interactions between organisms can produce both conflict and co-operation. When the interaction is between pairs of species, such as a pathogen and a host, or a predator and its prey, these species can develop matched sets of adaptations. Here, the evolution of one species causes adaptations in a second species. These changes in the second species then, in turn, cause new adaptations in the first species. This cycle of selection and response is called co-evolution. An example is the production of tetrodotoxin in the rough-skinned newt and the evolution of tetrodotoxin resistance in its predator, the common garter snake. In this predator-prey pair, an evolutionary arms race has produced high levels of toxin in the newt and correspondingly high levels of toxin resistance in the snake.

Co-operation

Not all co-evolved interactions between species involve conflict. Many cases of mutually beneficial interactions have evolved. For instance, an extreme cooperation exists between plants and the mycorrhizal fungi that grow on their roots and aid the plant in absorbing nutrients from the soil. This is a reciprocal relationship as the plants provide the fungi with sugars from photosynthesis. Here, the fungi actually grow inside plant cells, allowing them to exchange nutrients with their hosts, while sending signals that suppress the plant immune system.

Coalitions between organisms of the same species have also evolved. An extreme case is the eusociality found in social insects, such as bees, termites and ants, where sterile insects feed and guard the small number of organisms in a colony that are able to reproduce. On an even smaller scale, the somatic cells that make up the body of an animal limit their reproduction so they can maintain a stable organism, which then supports a small number of the animal's germ cells to produce offspring. Here, somatic cells respond to specific signals that instruct them whether to grow, remain as they are, or die. If cells ignore these signals and multiply inappropriately, their uncontrolled growth causes cancer.

Such cooperation within species may have evolved through the process of kin selection, which is where one organism acts to help raise a relative's offspring. This activity is selected for because if the helping individual contains alleles which promote the helping activity, it is likely that its kin will also contain these alleles and thus those alleles will be passed on. Other processes that may promote cooperation include group selection, where cooperation provides benefits to a group of organisms.

Speciation

Speciation is the process where a species diverges into two or more descendant species.

There are multiple ways to define the concept of "species". The choice of definition is dependent on the particularities of the species concerned. For example, some species concepts apply more readily toward sexually reproducing organisms while others lend themselves better toward asexual organisms. Despite the diversity of various species concepts, these various concepts can be placed into one of three broad philosophical approaches: interbreeding, ecological and phylogenetic. The biological species concept (BSC) is a classic example of the interbreeding approach. Defined by Ernst Mayr in 1942, the BSC states that "species are groups of actually or potentially interbreeding natural populations, which are reproductively isolated from other such groups". Despite its wide and long-term use, the BSC like others is not without controversy, for example because these concepts cannot be applied to prokaryotes, and this is called the species problem. Some researchers have attempted a unifying monistic definition of species, while others adopt a pluralistic approach and suggest that there may be different ways to logically interpret the definition of a species.

Barriers to reproduction between two diverging sexual populations are required for the populations to become new species. Gene flow may slow this process by spreading the new genetic variants also to the other populations. Depending on how far two species have diverged since their most recent common ancestor, it may still be possible for them to produce offspring, as with horses and donkeys mating to produce mules. Such hybrids are generally infertile. In this case, closely related species may regularly interbreed, but hybrids will be selected against and the species will remain distinct. However, viable hybrids are occasionally formed and these new species can either have properties intermediate between their parent species, or possess a totally new phenotype. The importance of hybridisation in producing new species of animals is unclear, although cases have been seen in many types of animals, with the gray tree frog being a particularly well-studied example.

Speciation has been observed multiple times under both controlled laboratory conditions and in nature. In sexually reproducing organisms, speciation results from reproductive isolation followed by genealogical divergence. There are four mechanisms for speciation. The most common in animals is allopatric speciation, which occurs in populations initially isolated geographically, such as by habitat fragmentation or migration. Selection under these conditions can produce very rapid changes in the appearance and behaviour of organisms. As selection and drift act independently on populations isolated from the rest of their species, separation may eventually produce organisms that cannot interbreed.

The second mechanism of speciation is peripatric speciation, which occurs when small populations of organisms become isolated in a new environment. This differs from allopatric speciation in that the isolated populations are numerically much smaller than the parental population. Here, the founder effect causes rapid speciation after an increase in inbreeding increases selection on homozygotes, leading to rapid genetic change.

The third mechanism of speciation is parapatric speciation. This is similar to peripatric speciation in that a small population enters a new habitat, but differs in that there is no physical separation between these two populations. Instead, speciation results from the evolution of mechanisms that reduce gene flow between the two populations. Generally this occurs when there has been a drastic change in the environment within the parental species' habitat. One example is the grass Anthoxanthum odoratum, which can undergo parapatric speciation in response to localised metal pollution from mines. Here, plants evolve that have resistance to high levels of metals in the soil. Selection against interbreeding with the metal-sensitive parental population produced a gradual change in the flowering time of the metal-resistant plants, which eventually produced complete reproductive isolation. Selection against hybrids between the two populations may cause reinforcement, which is the evolution of traits that promote mating within a species, as well as character displacement, which is when two species become more distinct in appearance.

Finally, in sympatric speciation species diverge without geographic isolation or changes in habitat. This form is rare since even a small amount of gene flow may remove genetic differences between parts of a population. Generally, sympatric speciation in animals requires the evolution of both genetic differences and non-random mating, to allow reproductive isolation to evolve.

One type of sympatric speciation involves cross-breeding of two related species to produce a new hybrid species. This is not common in animals as animal hybrids are usually sterile. This is because during meiosis the homologous chromosomes from each parent are from different species and cannot successfully pair. However, it is more common in plants because plants often double their number of chromosomes, to form polyploids. This allows the chromosomes from each parental species to form matching pairs during meiosis, since each parent's chromosomes are represented by a pair already. An example of such a speciation event is when the plant species Arabidopsis thaliana and Arabidopsis arenosa cross-bred to give the new species Arabidopsis suecica. This happened about 20,000 years ago, and the speciation process has been repeated in the laboratory, which allows the study of the genetic mechanisms involved in this process. Indeed, chromosome doubling within a species may be a common cause of reproductive isolation, as half the doubled chromosomes will be unmatched when breeding with undoubled organisms.

Speciation events are important in the theory of punctuated equilibrium, which accounts for the pattern in the fossil record of short "bursts" of evolution interspersed with relatively long periods of stasis, where species remain relatively unchanged. In this theory, speciation and rapid evolution are linked, with natural selection and genetic drift acting most strongly on organisms undergoing speciation in novel habitats or small populations. As a result, the periods of stasis in the fossil record correspond to the parental population and the organisms undergoing speciation and rapid evolution are found in small populations or geographically restricted habitats and therefore rarely being preserved as fossils.

Extinction

Extinction is the disappearance of an entire species. Extinction is not an unusual event, as species regularly appear through speciation and disappear through extinction. Nearly all animal and plant species that have lived on Earth are now extinct, and extinction appears to be the ultimate fate of all species. These extinctions have happened continuously throughout the history of life, although the rate of extinction spikes in occasional mass extinction events. The Cretaceous–Paleogene extinction event, during which the non-avian dinosaurs went extinct, is the most well-known, but the earlier Permian–Triassic extinction event was even more severe, with approximately 96% of species driven to extinction. The Holocene extinction event is an ongoing mass extinction associated with humanity's expansion across the globe over the past few thousand years. Present-day extinction rates are 100–1000 times greater than the background rate and up to 30% of current species may be extinct by the mid 21st century. Human activities are now the primary cause of the ongoing extinction event; global warming may further accelerate it in the future.

The role of extinction in evolution is not very well understood and may depend on which type of extinction is considered. The causes of the continuous "low-level" extinction events, which form the majority of extinctions, may be the result of competition between species for limited resources (competitive exclusion). If one species can out-compete another, this could produce species selection, with the fitter species surviving and the other species being driven to extinction. The intermittent mass extinctions are also important, but instead of acting as a selective force, they drastically reduce diversity in a nonspecific manner and promote bursts of rapid evolution and speciation in survivors.

Evolutionary history of life

Origin of life

Highly energetic chemistry is thought to have produced a self-replicating molecule around 4 billion years ago, and half a billion years later the last common ancestor of all life existed. The current scientific consensus is that the complex biochemistry that makes up life came from simpler chemical reactions. The beginning of life may have included self-replicating molecules such as RNA and the assembly of simple cells.

Common descent

All organisms on Earth are descended from a common ancestor or ancestral gene pool. Current species are a stage in the process of evolution, with their diversity the product of a long series of speciation and extinction events. The common descent of organisms was first deduced from four simple facts about organisms: First, they have geographic distributions that cannot be explained by local adaptation. Second, the diversity of life is not a set of completely unique organisms, but organisms that share morphological similarities. Third, vestigial traits with no clear purpose resemble functional ancestral traits and finally, that organisms can be classified using these similarities into a hierarchy of nested groups – similar to a family tree. However, modern research has suggested that, due to horizontal gene transfer, this "tree of life" may be more complicated than a simple branching tree since some genes have spread independently between distantly related species.

Past species have also left records of their evolutionary history. Fossils, along with the comparative anatomy of present-day organisms, constitute the morphological, or anatomical, record. By comparing the anatomies of both modern and extinct species, paleontologists can infer the lineages of those species. However, this approach is most successful for organisms that had hard body parts, such as shells, bones or teeth. Further, as prokaryotes such as bacteria and archaea share a limited set of common morphologies, their fossils do not provide information on their ancestry.

More recently, evidence for common descent has come from the study of biochemical similarities between organisms. For example, all living cells use the same basic set of nucleotides and amino acids. The development of molecular genetics has revealed the record of evolution left in organisms' genomes: dating when species diverged through the molecular clock produced by mutations. For example, these DNA sequence comparisons have revealed that humans and chimpanzees share 98% of their genomes and analysing the few areas where they differ helps shed light on when the common ancestor of these species existed.

Evolution of life

Prokaryotes inhabited the Earth from approximately 3–4 billion years ago. No obvious changes in morphology or cellular organisation occurred in these organisms over the next few billion years. The eukaryotic cells emerged between 1.6 – 2.7 billion years ago. The next major change in cell structure came when bacteria were engulfed by eukaryotic cells, in a cooperative association called endosymbiosis. The engulfed bacteria and the host cell then underwent co-evolution, with the bacteria evolving into either mitochondria or hydrogenosomes. Another engulfment of cyanobacterial-like organisms led to the formation of chloroplasts in algae and plants.

The history of life was that of the unicellular eukaryotes, prokaryotes and archaea until about 610 million years ago when multicellular organisms began to appear in the oceans in the Ediacaran period. The evolution of multicellularity occurred in multiple independent events, in organisms as diverse as sponges, brown algae, cyanobacteria, slime moulds and myxobacteria.

Soon after the emergence of these first multicellular organisms, a remarkable amount of biological diversity appeared over approximately 10 million years, in an event called the Cambrian explosion. Here, the majority of types of modern animals appeared in the fossil record, as well as unique lineages that subsequently became extinct. Various triggers for the Cambrian explosion have been proposed, including the accumulation of oxygen in the atmosphere from photosynthesis.

About 500 million years ago, plants and fungi colonised the land and were soon followed by arthropods and other animals. Insects were particularly successful and even today make up the majority of animal species. Amphibians first appeared around 364 million years ago, followed by early amniotes and birds around 155 million years ago (both from "reptile"-like lineages), mammals around 129 million years ago, homininae around 10 million years ago and modern humans around 250,000 years ago. However, despite the evolution of these large animals, smaller organisms similar to the types that evolved early in this process continue to be highly successful and dominate the Earth, with the majority of both biomass and species being prokaryotes.

Applications

Concepts and models used in evolutionary biology, such as natural selection, have many applications.

Artificial selection is the intentional selection of traits in a population of organisms. This has been used for thousands of years in the domestication of plants and animals. More recently, such selection has become a vital part of genetic engineering, with selectable markers such as antibiotic resistance genes being used to manipulate DNA. Proteins with valuable properties have evolved by repeated rounds of mutation and selection (for example modified enzymes and new antibodies) in a process called directed evolution.

Understanding the changes that have occurred during an organism's evolution can reveal the genes needed to construct parts of the body, genes which may be involved in human genetic disorders. For example, the Mexican tetra is an albino cavefish that lost its eyesight during evolution. Breeding together different populations of this blind fish produced some offspring with functional eyes, since different mutations had occurred in the isolated populations that had evolved in different caves. This helped identify genes required for vision and pigmentation.

Many human diseases are not static phenomena, but capable of evolution. Viruses, bacteria, fungi and cancers evolve to be resistant to host immune defences, as well as pharmaceutical drugs. These same problems occur in agriculture with pesticide and herbicide resistance. It is possible that we are facing the end of the effective life of most of available antibiotics and predicting the evolution and evolvability of our pathogens and devising strategies to slow or circumvent it is requiring deeper knowledge of the complex forces driving evolution at the molecular level.

In computer science, simulations of evolution using evolutionary algorithms and artificial life started in the 1960s and were extended with simulation of artificial selection. Artificial evolution became a widely recognised optimisation method as a result of the work of Ingo Rechenberg in the 1960s. He used evolution strategies to solve complex engineering problems. Genetic algorithms in particular became popular through the writing of John Holland. Practical applications also include automatic evolution of computer programmes. Evolutionary algorithms are now used to solve multi-dimensional problems more efficiently than software produced by human designers and also to optimise the design of systems.

Social and cultural responses

In the 19th century, particularly after the publication of On the Origin of Species in 1859, the idea that life had evolved was an active source of academic debate centred on the philosophical, social and religious implications of evolution. Today, the modern evolutionary synthesis is accepted by a vast majority of scientists. However, evolution remains a contentious concept for some theists.

While various religions and denominations have reconciled their beliefs with evolution through concepts such as theistic evolution, there are creationists who believe that evolution is contradicted by the creation myths found in their religions and who raise various objections to evolution. As had been demonstrated by responses to the publication of Vestiges of the Natural History of Creation in 1844, the most controversial aspect of evolutionary biology is the implication of human evolution that humans share common ancestry with apes and that the mental and moral faculties of humanity have the same types of natural causes as other inherited traits in animals. In some countries, notably the United States, these tensions between science and religion have fuelled the current creation-evolution controversy, a religious conflict focusing on politics and public education. While other scientific fields such as cosmology and Earth science also conflict with literal interpretations of many religious texts, evolutionary biology experiences significantly more opposition from religious literalists.

The teaching of evolution in American secondary school biology classes was uncommon in most of the first half of the 20th century. The Scopes Trial decision of 1925 caused the subject to become very rare in American secondary biology textbooks for a generation, but it was gradually re-introduced later and became legally protected with the 1968 Epperson v. Arkansas decision. Since then, the competing religious belief of creationism was legally disallowed in secondary school curricula in various decisions in the 1970s and 1980s, but it returned in pseudoscientific form as intelligent design, to be excluded once again in the 2005 Kitzmiller v. Dover Area School District case.

See also

Template:Misplaced Pages books

References

1. Tradition: ‘A behaviour pattern transmitted repeatedly through social learning to become a population-level characteristic’.The Evolution of Culture by Andrew Whiten
2. The forces affecting language and the evolution which a language continually undergoes are covered, with historical changes in spellings, meanings, and sounds traced in some detail.Aspects of Language. - Bolinger, Dwight
3. Coping with huge amounts of data is one of the major problems in the context of software evolution.Understanding Software Evolution using a Combination of Software Visualization and Software Metrics (2002) by Michele Lanza , Stéphane Ducasse
4. We describe GEVOL, a system that visualizes the evolution of software using a novel graph drawing technique for visualization of large graphs with a temporal component.A system for graph-based visualization of the evolution of software
5. This paper draws on an evolutionary theory of economic growth that brings together appreciative theorizing regarding growth and formal theorizing.The Co-evolution of Technology, Industrial Structure, and Supporting Institutions by RICHARD R. NELSON
6. The analysis of the evolution of knowledge is distinguished from standard economics and neoDarwinian biology; it combines purpose with the impossibility of empirical proof.The Evolution of Knowledge: Beyond the Biological Model by Brian J. Loasby
7. Nursing Research has made a significant contribution in disseminating the body of tested knowledge related to the health disparities experienced by vulnerable populations and the methodologies associated with vulnerable populations research.Health Disparities Among Vulnerable Populations: Evolution of Knowledge Over Five Decades in Nursing Research Publications
8. The paper covers the evolution of drilling mechanization and automation from the mid-nineteenth century to today.The Evolution of Automation in Drilling
9. From these considerations, I shall devote the first chapter of this Abstract to Variation under Domestication. We shall thus see that a large amount of hereditary modification is at least possible, and, what is equally or more important, we shall see how great is the power of man in accumulating by his Selection successive slight variations.On the Origin of Species By Means of Natural Selection by Charles Darwin - 1st Edition
10. Hall & Hallgrímsson 2008, pp. 3–5
11. ^ Doolittle, W. Ford (February 2000). "Uprooting the Tree of Life". Scientific American. 282 (2). London: Nature Publishing Group: 90–95. doi:10.1038/scientificamerican0200-90. ISSN 0036-8733. PMID 10710791.
12. Glansdorff, Nicolas; Ying Xu; Labedan, Bernard (July 9, 2008). "The Last Universal Common Ancestor: emergence, constitution and genetic legacy of an elusive forerunner". Biology Direct. 3. London: BioMed Central: 29. doi:10.1186/1745-6150-3-29. ISSN 1745-6150. PMC 2478661. PMID 18613974.{{cite journal}}: CS1 maint: unflagged free DOI (link)
13. Panno 2005, pp. xv-16
14. Futuyma 2004, p. 33
15. Lewontin, R. C. (November 1970). "The Units of Selection". Annual Review of Ecology and Systematics. 1. Palo Alto, CA: Annual Reviews: 1–18. doi:10.1146/annurev.es.01.110170.000245. ISSN 1545-2069. JSTOR 2096764.
16. Darwin 1859, Chapter XIV
17. ^ Kimura, Motoo (1991). "The neutral theory of molecular evolution: a review of recent evidence". The Japanese Journal of Human Genetics. 66 (4). Mishima, Japan: Genetics Society of Japan: 367–386. doi:10.1266/jjg.66.367. ISSN 0021-504X. PMID 1954033. {{cite journal}}: Invalid |ref=harv (help)
18. Provine 1988, pp. 49–79
19. NAS 2008, pp. R11–R12
20. Moore, Decker & Cotner 2010, p. 454
21. Futuyma, Douglas J., ed. (1999). "Evolution, Science, and Society: Evolutionary Biology and the National Research Agenda" (PDF) (Executive summary). New Brunswick, NJ: Office of University Publications, Rutgers, The State University of New Jersey. OCLC 43422991. Archived from the original (PDF) on 2012-01-31. Retrieved 2014-11-24.
22. Kirk, Raven & Schofield 1983, pp. 100–142, 280–321
23. Lucretius. "Book V, lines 855–877". De Rerum Natura. Edited and translated by William Ellery Leonard (1916). Medford/Somerville, MA: Tufts University. OCLC 33233743. {{cite book}}: |access-date= requires |url= (help); |website= ignored (help); External link in |chapterurl= (help); Unknown parameter |chapterurl= ignored (|chapter-url= suggested) (help)
24. Sedley, David (2003). "Lucretius and the New Empedocles" (PDF). Leeds International Classical Studies. 2 (4). Leeds, West Yorkshire, England: Leeds International Classics Seminar. ISSN 1477-3643. Retrieved 2014-11-25.
25. Torrey, Harry Beal; Felin, Frances (March 1937). "Was Aristotle an Evolutionist?". The Quarterly Review of Biology. 12 (1): 1–18. doi:10.1086/394520. ISSN 0033-5770. JSTOR 2808399.
26. Hull, David L. (December 1967). "The Metaphysics of Evolution". The British Journal for the History of Science. 3 (4). Cambridge: Cambridge University Press: 309–337. doi:10.1017/S0007087400002892. JSTOR 4024958.
27. Mason 1962, pp. 43–44
28. Mayr 1982, pp. 256–257
    • Ray 1686
29. Waggoner, Ben (July 7, 2000). "Carl Linnaeus (1707-1778)". Evolution (Online exhibit). Berkeley, CA: University of California Museum of Paleontology. Retrieved 2012-02-11.
30. Darwin 1909, p. 53
31. Bowler 2003, pp. 73–75
32. "Erasmus Darwin (1731-1802)". Evolution (Online exhibit). Berkeley, CA: University of California Museum of Paleontology. October 4, 1995. Retrieved February 11, 2012.
33. Lamarck 1809
34. ^ Nardon & Grenier 1991, p. 162
35. ^ Gould 2002 harvnb error: multiple targets (2×): CITEREFGould2002 (help)
36. Ghiselin, Michael T. (September–October 1994). "The Imaginary Lamarck: A Look at Bogus 'History' in Schoolbooks". The Textbook Letter. Sausalito, CA: The Textbook League. OCLC 23228649. Retrieved 2008-01-23.
37. Magner 2002
38. Jablonka, Eva; Lamb, Marion J. (August 2007). "Précis of Evolution in Four Dimensions". Behavioural and Brain Sciences. 30 (4). Cambridge: Cambridge University Press: 353–365. doi:10.1017/S0140525X07002221. ISSN 0140-525X.
39. Burkhardt & Smith 1991
    • "Darwin, C. R. to Lubbock, John". Darwin Correspondence Project. Cambridge, UK: University of Cambridge. Retrieved 2014-12-01. Letter 2532, November 22, 1859.
40. Sulloway, Frank J. (June 2009). "Why Darwin rejected intelligent design". Journal of Biosciences. 34 (2). Bangalore: Indian Academy of Sciences: 173–183. doi:10.1007/s12038-009-0020-8. ISSN 0250-5991. PMID 19550032.
41. Dawkins 1990
42. Sober, Elliott (June 16, 2009). "Did Darwin write the Origin backwards?". Proc. Natl. Acad. Sci. U.S.A. 106 (Suppl. 1). Washington, D.C.: National Academy of Sciences: 10048–10055. Bibcode:2009PNAS..10610048S. doi:10.1073/pnas.0901109106. ISSN 0027-8424.
43. Mayr 2002, p. 165
44. Bowler 2003, pp. 145–146
45. Sokal, Robert R.; Crovello, Theodore J. (March–April 1970). "The Biological Species Concept: A Critical Evaluation". The American Naturalist. 104 (936). Chicago, IL: University of Chicago Press on behalf of the American Society of Naturalists: 127–153. doi:10.1086/282646. ISSN 0003-0147. JSTOR 2459191.
46. Darwin, Charles; Wallace, Alfred (August 20, 1858). "On the Tendency of Species to form Varieties; and on the Perpetuation of Varieties and Species by Natural Means of Selection". Journal of the Proceedings of the Linnean Society of London. Zoology. 3 (9): 45–62. doi:10.1111/j.1096-3642.1858.tb02500.x. ISSN 1096-3642. Retrieved 2007-05-13. {{cite journal}}: Invalid |ref=harv (help)
47. Desmond, Adrian J. (July 17, 2014). "Thomas Henry Huxley". Encyclopædia Britannica Online. Chicago, IL: Encyclopædia Britannica, Inc. Retrieved 2014-12-02.
48. Liu, Y. S.; Zhou, X. M.; Zhi, M. X.; Li, X. J.; Wang, Q. L. (September 2009). "Darwin's contributions to genetics". Journal of Applied Genetics. 50 (3). Poznań: Institute of Plant Genetics, Polish Academy of Sciences: 177–184. doi:10.1007/BF03195671. ISSN 1234-1983. PMID 19638672.
49. Weiling, Franz (July 1991). "Historical study: Johann Gregor Mendel 1822–1884". American Journal of Medical Genetics. 40 (1): 1–25, discussion 26. doi:10.1002/ajmg.1320400103. PMID 1887835. {{cite journal}}: Invalid |ref=harv (help)
50. Wright 1984, p. 480
51. Provine 1971
52. Stamhuis, Ida H.; Meijer, Onno G.; Zevenhuizen, Erik J. A. (June 1999). "Hugo de Vries on Heredity, 1889-1903: Statistics, Mendelian Laws, Pangenes, Mutations". Isis. 90 (2). Chicago, IL: University of Chicago Press: 238–267. doi:10.1086/384323. ISSN 0021-1753. JSTOR 237050. PMID 10439561.
53. Quammen 2006
54. Bowler 1989
55. Watson, J. D.; Crick, F. H. C. (April 25, 1953). "Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid" (PDF). Nature. 171 (4356). London: Nature Publishing Group: 737–738. Bibcode:1953Natur.171..737W. doi:10.1038/171737a0. ISSN 0028-0836. PMID 13054692. Retrieved 2014-12-04.
56. Hennig 1999, p. 280
57. Wiley & Lieberman 2011
58. Dobzhansky, Theodosius (March 1973). "Nothing in Biology Makes Sense Except in the Light of Evolution". The American Biology Teacher. 35 (3). McLean, VA: National Association of Biology Teachers: 125–129. doi:10.2307/4444260. {{cite journal}}: Invalid |ref=harv (help)
59. ^ Kutschera, Ulrich; Niklas, Karl J. (June 2004). "The modern theory of biological evolution: an expanded synthesis". Naturwissenschaften. 91 (6). Heidelberg: Springer-Verlag Heidelberg: 255–276. Bibcode:2004NW.....91..255K. doi:10.1007/s00114-004-0515-y. ISSN 1432-1904. PMID 15241603. {{cite journal}}: Invalid |ref=harv (help)
60. Cracraft & Bybee 2005
61. Avise, John C.; Ayala, Francisco J. (May 11, 2010). "In the light of evolution IV: The human condition" (PDF). Proc. Natl. Acad. Sci. U.S.A. 107 (Suppl. 2). Washington, D.C.: National Academy of Sciences: 8897–8901. doi:10.1073/pnas.100321410. ISSN 0027-8424.
62. Sturm, Richard A.; Frudakis, Tony N. (August 2004). "Eye colour: portals into pigmentation genes and ancestry". Trends in Genetics. 20 (8). Cambridge, MA: Cell Press: 327–332. doi:10.1016/j.tig.2004.06.010. ISSN 0168-9525. PMID 15262401. {{cite journal}}: Invalid |ref=harv (help)
63. ^ Pearson, Helen (May 25, 2006). "Genetics: What is a gene?". Nature. 441 (7092). London: Nature Publishing Group: 398–401. Bibcode:2006Natur.441..398P. doi:10.1038/441398a. ISSN 0028-0836. PMID 16724031. {{cite journal}}: Invalid |ref=harv (help)
64. Visscher, Peter M.; Hill, William G.; Wray, Naomi R. (April 2008). "Heritability in the genomics era — concepts and misconceptions". Nature Reviews Genetics. 9 (4). London: Nature Publishing Group: 255–266. doi:10.1038/nrg2322. ISSN 1471-0056. PMID 18319743. {{cite journal}}: Invalid |ref=harv (help)
65. Oetting, William S.; Brilliant, Murray H.; King, Richard A. (August 1996). "The clinical spectrum of albinism in humans". Molecular Medicine Today. 2 (8). Cambridge, MA: Cell Press: 330–335. doi:10.1016/1357-4310(96)81798-9. ISSN 1357-4310. PMID 8796918. {{cite journal}}: Invalid |ref=harv (help)
66. ^ Futuyma 2005
67. Phillips, Patrick C. (November 2008). "Epistasis—the essential role of gene interactions in the structure and evolution of genetic systems". Nature Reviews Genetics. 9 (11). London: Nature Publishing Group: 855–867. doi:10.1038/nrg2452. ISSN 1471-0056. PMC 2689140. PMID 18852697. {{cite journal}}: Invalid |ref=harv (help)
68. ^ Rongling Wu; Min Lin (March 2006). "Functional mapping — how to map and study the genetic architecture of dynamic complex traits". Nature Reviews Genetics. 7 (3). London: Nature Publishing Group: 229–237. doi:10.1038/nrg1804. ISSN 1471-0056. PMID 16485021. {{cite journal}}: Invalid |ref=harv (help)
69. Jablonka, Eva; Raz, Gal (June 2009). "Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution". The Quarterly Review of Biology. 84 (2). Chicago, IL: University of Chicago Press: 131–176. doi:10.1086/598822. ISSN 0033-5770. PMID 19606595.
70. Bossdorf, Oliver; Arcuri, Davide; Richards, Christina L.; Pigliucci, Massimo (May 2010). "Experimental alteration of DNA methylation affects the phenotypic plasticity of ecologically relevant traits in Arabidopsis thaliana". Evolutionary Ecology. 24 (3). Dordrecht, the Netherlands: Springer Netherlands: 541–553. doi:10.1007/s10682-010-9372-7. ISSN 0269-7653.
71. Jablonka & Lamb 2005
72. Jablonka, Eva; Lamb, Marion J. (December 2002). "The Changing Concept of Epigenetics". Annals of the New York Academy of Sciences. 981 (1). Hoboken, NJ: Wiley-Blackwell, on behalf of the New York Academy of Sciences: 82–96. Bibcode:2002NYASA.981...82J. doi:10.1111/j.1749-6632.2002.tb04913.x. ISSN 0077-8923. PMID 12547675.
73. Laland, Kevin N.; Sterelny, Kim (September 2006). "Perspective: Seven Reasons (Not) to Neglect Niche Construction". Evolution. 60 (9). Hoboken, NJ: John Wiley & Sons on behalf of the Society for the Study of Evolution: 1751–1762. doi:10.1111/j.0014-3820.2006.tb00520.x. ISSN 0014-3820.
74. Chapman, Michael J.; Margulis, Lynn (December 1998). "Morphogenesis by symbiogenesis" (PDF). International Microbiology. 1 (4). Barcelona: Spanish Society for Microbiology: 319–326. ISSN 1139-6709. PMID 10943381. Retrieved 2014-12-09.
75. Wilson, David Sloan; Wilson, Edward O. (December 2007). "Rethinking the Theoretical Foundation of Sociobiology" (PDF). The Quarterly Review of Biology. 82 (4). Chicago, IL: University of Chicago Press: 327–348. doi:10.1086/522809. ISSN 0033-5770. PMID 18217526.
76. Amos, William; Harwood, John (February 28, 1998). "Factors affecting levels of genetic diversity in natural populations". Philosophical Transactions of the Royal Society B: Biological Sciences. 353 (1366). London: Royal Society: 177–186. doi:10.1098/rstb.1998.0200. ISSN 0962-8436. PMC 1692205. PMID 9533122. {{cite journal}}: Invalid |ref=harv (help)
77. ^ Ewens 2004
78. Butlin, Roger K.; Tregenza, Tom (February 28, 1998). "Levels of genetic polymorphism: marker loci versus quantitative traits". Philosophical Transactions of the Royal Society B: Biological Sciences. 353 (1366). London: Royal Society: 187–198. doi:10.1098/rstb.1998.0201. ISSN 0962-8436. PMC 1692210. PMID 9533123. {{cite journal}}: Invalid |ref=harv (help)
    • Butlin, Roger K.; Tregenza, Tom (December 29, 2000). "Correction for Butlin and Tregenza, Levels of genetic polymorphism: marker loci versus quantitative traits". Philosophical Transactions of the Royal Society B: Biological Sciences. 355 (1404). London: Royal Society. doi:10.1098/rstb.2000.2000. ISSN 0962-8436. Some of the values in table 1 on p. 193 were given incorrectly. The errors do not affect the conclusions drawn in the paper. The corrected table is reproduced below.
79. Wetterbom, Anna; Sevov, Marie; Cavelier, Lucia; Bergström, Tomas F. (November 2006). "Comparative Genomic Analysis of Human and Chimpanzee Indicates a Key Role for Indels in Primate Evolution". Journal of Molecular Evolution. 63 (5). New York: Springer-Verlag New York: 682–690. doi:10.1007/s00239-006-0045-7. ISSN 0022-2844. PMID 17075697. {{cite journal}}: Invalid |ref=harv (help)
80. Sawyer, Stanley A.; Parsch, John; Zhang Zhi; Hartl, Daniel L. (Apr 17, 2007). "Prevalence of positive selection among nearly neutral amino acid replacements in Drosophila". Proc. Natl. Acad. Sci. U.S.A. 104 (16). Washington, D.C.: National Academy of Sciences: 6504–6510. Bibcode:2007PNAS..104.6504S. doi:10.1073/pnas.0701572104. ISSN 0027-8424. PMC 1871816. PMID 17409186. {{cite journal}}: Invalid |ref=harv (help)
81. Hastings, P. J.; Lupski, James R.; Rosenberg, Susan M.; Ira, Grzegorz (August 2009). "Mechanisms of change in gene copy number". Nature Reviews Genetics. 10 (8). London: Nature Publishing Group: 551–564. doi:10.1038/nrg2593. ISSN 1471-0056. PMC 2864001. PMID 19597530. {{cite journal}}: Invalid |ref=harv (help)
82. Carroll, Grenier & Weatherbee 2005
83. Harrison, Paul M.; Gerstein, Mark (May 17, 2002). "Studying Genomes Through the Aeons: Protein Families, Pseudogenes and Proteome Evolution". Journal of Molecular Biology. 318 (5). Amsterdam, the Netherlands: Elsevier: 1155–1174. doi:10.1016/S0022-2836(02)00109-2. ISSN 0022-2836. PMID 12083509. {{cite journal}}: Invalid |ref=harv (help)
84. Bowmaker, James K. (May 1998). "Evolution of colour vision in vertebrates". Eye. 12 (3b). London: Nature Publishing Group on behalf of the Royal College of Ophthalmologists: 541–547. doi:10.1038/eye.1998.143. ISSN 0950-222X. PMID 9775215. {{cite journal}}: Invalid |ref=harv (help)
85. Gregory, T. Ryan; Hebert, Paul D. N. (April 1999). "The Modulation of DNA Content: Proximate Causes and Ultimate Consequences". Genome Research. 9 (4). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press: 317–324. doi:10.1101/gr.9.4.317. ISSN 1549-5469. PMID 10207154. Retrieved 2014-12-11. {{cite journal}}: Invalid |ref=harv (help)
86. Hurles, Matthew (July 2004). "Gene Duplication: The Genomic Trade in Spare Parts". PLOS Biology. 2 (7). San Francisco, CA: Public Library of Science: E206. doi:10.1371/journal.pbio.0020206. ISSN 1544-9173. PMC 449868. PMID 15252449. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: unflagged free DOI (link)
87. Liu, Na; Okamura, Katsutomo; Tyler, David M.; et al. (October 2008). "The evolution and functional diversification of animal microRNA genes". Cell Research. 18 (10). London: Nature Publishing Group on behalf of the Shanghai Institutes for Biological Sciences: 985–996. doi:10.1038/cr.2008.278. ISSN 1001-0602. PMC 2712117. PMID 18711447. Retrieved 2014-12-11. {{cite journal}}: Invalid |ref=harv (help)
88. Siepel, Adam (October 2009). "Darwinian alchemy: Human genes from noncoding DNA". Genome Research. 19 (10). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press: 1693–1695. doi:10.1101/gr.098376.109. ISSN 1549-5469. PMC 2765273. PMID 19797681. Retrieved 2014-12-11. {{cite journal}}: Invalid |ref=harv (help)
89. Orengo, Christine A.; Thornton, Janet M. (July 2005). "Protein families and their evolution—a structural perspective". Annual Review of Biochemistry. 74. Palo Alto, CA: Annual Reviews: 867–900. doi:10.1146/annurev.biochem.74.082803.133029. ISSN 0066-4154. PMID 15954844. {{cite journal}}: Invalid |ref=harv (help)
90. Long, Manyuan; Betrán, Esther; Thornton, Kevin; Wang, Wen (November 2003). "The origin of new genes: glimpses from the young and old". Nature Reviews Genetics. 4 (11). London: Nature Publishing Group: 865–875. doi:10.1038/nrg1204. ISSN 1471-0056. PMID 14634634. {{cite journal}}: Invalid |ref=harv (help)
91. Wang, Minglei; Caetano-Anollés, Gustavo (January 14, 2009). "The Evolutionary Mechanics of Domain Organization in Proteomes and the Rise of Modularity in the Protein World". Structure. 17 (1). Cambridge, MA: Cell Press: 66–78. doi:10.1016/j.str.2008.11.008. ISSN 1357-4310. PMID 19141283. {{cite journal}}: Invalid |ref=harv (help)
92. Weissman, Kira J.; Müller, Rolf (April 14, 2008). "Protein–Protein Interactions in Multienzyme Megasynthetases". ChemBioChem. 9 (6). Weinheim, Germany: Wiley-VCH: 826–848. doi:10.1002/cbic.200700751. ISSN 1439-4227. PMID 18357594. {{cite journal}}: Invalid |ref=harv (help)
93. Radding, Charles M. (December 1982). "Homologous Pairing and Strand Exchange in Genetic Recombination". Annual Review of Genetics. 16. Palo Alto, CA: Annual Reviews: 405–437. doi:10.1146/annurev.ge.16.120182.002201. ISSN 0066-4197. PMID 6297377. {{cite journal}}: Invalid |ref=harv (help)
94. Agrawal, Aneil F. (September 5, 2006). "Evolution of Sex: Why Do Organisms Shuffle Their Genotypes?". Current Biology. 16 (17). Cambridge, MA: Cell Press: R696–R704. doi:10.1016/j.cub.2006.07.063. ISSN 0960-9822. PMID 16950096. {{cite journal}}: Invalid |ref=harv (help)
95. Peters, Andrew D.; Otto, Sarah P. (June 2003). "Liberating genetic variance through sex". BioEssays. 25 (6). Hoboken, NJ: John Wiley & Sons: 533–537. doi:10.1002/bies.10291. ISSN 0265-9247. PMID 12766942. {{cite journal}}: Invalid |ref=harv (help)
96. Goddard, Matthew R.; Godfray, H. Charles J.; Burt, Austin (March 31, 2005). "Sex increases the efficacy of natural selection in experimental yeast populations". Nature. 434 (7033). London: Nature Publishing Group: 636–640. Bibcode:2005Natur.434..636G. doi:10.1038/nature03405. ISSN 0028-0836. PMID 15800622. {{cite journal}}: Invalid |ref=harv (help)
97. ^ Morjan, Carrie L.; Rieseberg, Loren H. (June 2004). "How species evolve collectively: implications of gene flow and selection for the spread of advantageous alleles". Molecular Ecology. 13 (6). Hoboken, NJ: Wiley-Blackwell: 1341–1356. doi:10.1111/j.1365-294X.2004.02164.x. ISSN 0962-1083. PMC 2600545. PMID 15140081. {{cite journal}}: Invalid |ref=harv (help)
98. Boucher, Yan; Douady, Christophe J.; Papke, R. Thane; et al. (December 2003). "Lateral gene transfer and the origins of prokaryotic groups". Annual Review of Genetics. 37. Palo Alto, CA: Annual Reviews: 283–328. doi:10.1146/annurev.genet.37.050503.084247. ISSN 0066-4197. PMID 14616063. {{cite journal}}: Invalid |ref=harv (help)
99. Walsh, Timothy R. (October 2006). "Combinatorial genetic evolution of multiresistance". Current Opinion in Microbiology. 9 (5). Amsterdam, the Netherlands: Elsevier: 476–482. doi:10.1016/j.mib.2006.08.009. ISSN 1369-5274. PMID 16942901. {{cite journal}}: Invalid |ref=harv (help)
100. Kondo, Natsuko; Nikoh, Naruo; Ijichi, Nobuyuki; et al. (October 29, 2002). "Genome fragment of Wolbachia endosymbiont transferred to X chromosome of host insect". Proc. Natl. Acad. Sci. U.S.A. 99 (22). Washington, D.C.: National Academy of Sciences: 14280–14285. Bibcode:2002PNAS...9914280K. doi:10.1073/pnas.222228199. ISSN 0027-8424. PMC 137875. PMID 12386340. {{cite journal}}: Invalid |ref=harv (help)
101. Sprague, George F., Jr. (December 1991). "Genetic exchange between kingdoms". Current Opinion in Genetics & Development. 1 (4). Amsterdam, the Netherlands: Elsevier: 530–533. doi:10.1016/S0959-437X(05)80203-5. ISSN 0959-437X. PMID 1822285. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
102. Gladyshev, Eugene A.; Meselson, Matthew; Arkhipova, Irina R. (May 30, 2008). "Massive Horizontal Gene Transfer in Bdelloid Rotifers". Science. 320 (5880). Washington, D.C.: American Association for the Advancement of Science: 1210–1213. Bibcode:2008Sci...320.1210G. doi:10.1126/science.1156407. ISSN 0036-8075. PMID 18511688. {{cite journal}}: Invalid |ref=harv (help)
103. Baldo, Angela M.; McClure, Marcella A. (September 1999). "Evolution and Horizontal Transfer of dUTPase-Encoding Genes in Viruses and Their Hosts". Journal of Virology. 73 (9). Washington, D.C.: American Society for Microbiology: 7710–7721. ISSN 0022-538X. PMC 104298. PMID 10438861. {{cite journal}}: Invalid |ref=harv (help)
104. Rivera, Maria C.; Lake, James A. (September 9, 2004). "The ring of life provides evidence for a genome fusion origin of eukaryotes". Nature. 431 (7005). London: Nature Publishing Group: 152–155. Bibcode:2004Natur.431..152R. doi:10.1038/nature02848. ISSN 0028-0836. PMID 15356622. {{cite journal}}: Invalid |ref=harv (help)
105. ^ Hurst, Laurence D. (February 2009). "Fundamental concepts in genetics: genetics and the understanding of selection". Nature Reviews Genetics. 10 (2). London: Nature Publishing Group: 83–93. doi:10.1038/nrg2506. ISSN 1471-0056. PMID 19119264. {{cite journal}}: Invalid |ref=harv (help)
106. ^ Orr, H. Allen (August 2009). "Fitness and its role in evolutionary genetics". Nature Reviews Genetics. 10 (8). London: Nature Publishing Group: 531–539. doi:10.1038/nrg2603. ISSN 1471-0056. PMC 2753274. PMID 19546856. {{cite journal}}: Invalid |ref=harv (help)
107. Haldane, J. B. S. (March 14, 1959). "The Theory of Natural Selection To-Day". Nature. 183 (4663). London: Nature Publishing Group: 710–713. Bibcode:1959Natur.183..710H. doi:10.1038/183710a0. ISSN 0028-0836. PMID 13644170. {{cite journal}}: Invalid |ref=harv (help)
108. Lande, Russell; Arnold, Stevan J. (November 1983). "The Measurement of Selection on Correlated Characters". Evolution. 37 (6). Hoboken, NJ: John Wiley & Sons on behalf of the Society for the Study of Evolution: 1210–1226. doi:10.2307/2408842. ISSN 0014-3820. JSTOR 2408842. {{cite journal}}: Invalid |ref=harv (help)
109. Goldberg, Emma E.; Igić, Boris (November 2008). "On phylogenetic tests of irreversible evolution". Evolution. 62 (11). Hoboken, NJ: John Wiley & Sons on behalf of the Society for the Study of Evolution: 2727–2741. doi:10.1111/j.1558-5646.2008.00505.x. ISSN 0014-3820. PMID 18764918. {{cite journal}}: Invalid |ref=harv (help)
110. Collin, Rachel; Miglietta, Maria Pia (November 2008). "Reversing opinions on Dollo's Law". Trends in Ecology & Evolution. 23 (11). Cambridge, MA: Cell Press: 602–609. doi:10.1016/j.tree.2008.06.013. ISSN 0169-5347. PMID 18814933. {{cite journal}}: Invalid |ref=harv (help)
111. Hoekstra, Hopi E.; Hoekstra, Jonathan M.; Berrigan, David; et al. (July 31, 2001). "Strength and tempo of directional selection in the wild". Proc. Natl. Acad. Sci. U.S.A. 98 (16). Washington, D.C.: National Academy of Sciences: 9157–9160. Bibcode:2001PNAS...98.9157H. doi:10.1073/pnas.161281098. ISSN 0027-8424. PMC 55389. PMID 11470913. {{cite journal}}: Invalid |ref=harv (help)
112. Felsenstein, Joseph (November 1979). "Excursions along the Interface between Disruptive and Stabilizing Selection". Genetics. 93 (3). Bethesda, MD: Genetics Society of America: 773–795. ISSN 0016-6731. PMC 1214112. PMID 17248980. {{cite journal}}: Invalid |ref=harv (help)
113. Andersson, Malte; Simmons, Leigh W. (June 2006). "Sexual selection and mate choice". Trends in Ecology & Evolution. 21 (6). Cambridge, MA: Cell Press: 296–302. doi:10.1016/j.tree.2006.03.015. ISSN 0169-5347. PMID 16769428. {{cite journal}}: Invalid |ref=harv (help)
114. Kokko, Hanna; Brooks, Robert; McNamara, John M.; Alasdair I. (July 7, 2002). "The sexual selection continuum". Proceedings of the Royal Society B. 269 (1498). London: Royal Society: 1331–1340. doi:10.1098/rspb.2002.2020. ISSN 0962-8452. PMC 1691039. PMID 12079655. {{cite journal}}: Invalid |ref=harv (help)
115. Quinn, Thomas P.; Hendry, Andrew P.; Buck, Gregory B. (2001). "Balancing natural and sexual selection in sockeye salmon: interactions between body size, reproductive opportunity and vulnerability to predation by bears" (PDF). Evolutionary Ecology Research. 3: 917–937. ISSN 1522-0613. Retrieved 2014-12-15.
116. Hunt, John; Brooks, Robert; Jennions, Michael D.; et al. (December 23, 2004). "High-quality male field crickets invest heavily in sexual display but die young". Nature. 432 (7020). London: Nature Publishing Group: 1024–1027. Bibcode:2004Natur.432.1024H. doi:10.1038/nature03084. ISSN 0028-0836. PMID 15616562. {{cite journal}}: Invalid |ref=harv (help)
117. Odum 1971, p. 8
118. Okasha 2006
119. ^ Gould, Stephen Jay (February 28, 1998). "Gulliver's further travels: the necessity and difficulty of a hierarchical theory of selection". Philosophical Transactions of the Royal Society B: Biological Sciences. 353 (1366). London: Royal Society: 307–314. doi:10.1098/rstb.1998.0211. ISSN 0962-8436. PMC 1692213. PMID 9533127. {{cite journal}}: Invalid |ref=harv (help)
120. Mayr, Ernst (March 18, 1997). "The objects of selection". Proc. Natl. Acad. Sci. U.S.A. 94 (6). Washington, D.C.: National Academy of Sciences: 2091–2094. Bibcode:1997PNAS...94.2091M. doi:10.1073/pnas.94.6.2091. ISSN 0027-8424. PMC 33654. PMID 9122151. {{cite journal}}: Invalid |ref=harv (help)
121. Maynard Smith 1998, pp. 203–211, discussion 211–217
122. Hickey, Donal A. (1992). "Evolutionary dynamics of transposable elements in prokaryotes and eukaryotes". Genetica. 86 (1–3). Dordrecht, the Netherlands: Kluwer Academic Publishers: 269–274. doi:10.1007/BF00133725. ISSN 0016-6707. PMID 1334911. {{cite journal}}: Invalid |ref=harv (help)
123. Gould, Stephen Jay; Lloyd, Elisabeth A. (October 12, 1999). "Individuality and adaptation across levels of selection: how shall we name and generalise the unit of Darwinism?". Proc. Natl. Acad. Sci. U.S.A. 96 (21). Washington, D.C.: National Academy of Sciences: 11904–11909. Bibcode:1999PNAS...9611904G. doi:10.1073/pnas.96.21.11904. ISSN 0027-8424. PMC 18385. PMID 10518549. {{cite journal}}: Invalid |ref=harv (help)
124. Lynch, Michael (May 15, 2007). "The frailty of adaptive hypotheses for the origins of organismal complexity". Proc. Natl. Acad. Sci. U.S.A. 104 (Suppl. 1). Washington, D.C.: National Academy of Sciences: 8597–8604. Bibcode:2007PNAS..104.8597L. doi:10.1073/pnas.0702207104. ISSN 0027-8424. PMC 1876435. PMID 17494740. {{cite journal}}: Invalid |ref=harv (help)
125. Smith, Nick G.C.; Webster, Matthew T.; Ellegren, Hans (September 2002). "Deterministic Mutation Rate Variation in the Human Genome". Genome Research. 12 (9). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press: 1350–1356. doi:10.1101/gr.220502. ISSN 1549-5469. PMC 186654. PMID 12213772. {{cite journal}}: Invalid |ref=harv (help)
126. Petrov, Dmitri A.; Sangster, Todd A.; Johnston, J. Spencer; et al. (February 11, 2000). "Evidence for DNA Loss as a Determinant of Genome Size". Science. 287 (5455). Washington, D.C.: American Association for the Advancement of Science: 1060–1062. Bibcode:2000Sci...287.1060P. doi:10.1126/science.287.5455.1060. ISSN 0036-8075. PMID 10669421. {{cite journal}}: Invalid |ref=harv (help)
127. Petrov, Dmitri A. (May 2002). "DNA loss and evolution of genome size in Drosophila". Genetica. 115 (1). Dordrecht, the Netherlands: Kluwer Academic Publishers: 81–91. doi:10.1023/A:1016076215168. ISSN 0016-6707. PMID 12188050. {{cite journal}}: Invalid |ref=harv (help)
128. Kiontke, Karin; Barriere, Antoine; Kolotuev, Irina; et al. (November 2007). "Trends, Stasis, and Drift in the Evolution of Nematode Vulva Development". Current Biology. 17 (22). Cambridge, MA: Cell Press: 1925–1937. doi:10.1016/j.cub.2007.10.061. ISSN 0960-9822. PMID 18024125. {{cite journal}}: Invalid |ref=harv (help)
129. Braendle, Christian; Baer, Charles F.; Félix, Marie-Anne (March 12, 2010). Barsh, Gregory S. (ed.). "Bias and Evolution of the Mutationally Accessible Phenotypic Space in a Developmental System". PLOS Genetics. 6 (3). San Francisco, CA: Public Library of Science: e1000877. doi:10.1371/journal.pgen.1000877. ISSN 1553-7390. PMC 2837400. PMID 20300655. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: unflagged free DOI (link)
130. Palmer, A. Richard (October 29, 2004). "Symmetry breaking and the evolution of development". Science. 306 (5697). Washington, D.C.: American Association for the Advancement of Science: 828–833. Bibcode:2004Sci...306..828P. doi:10.1126/science.1103707. ISSN 0036-8075. PMID 15514148. {{cite journal}}: Invalid |ref=harv (help)
131. West-Eberhard 2003
132. Stoltzfus, Arlin; Yampolsky, Lev Y. (September–October 2009). "Climbing Mount Probable: Mutation as a Cause of Nonrandomness in Evolution". Journal of Heredity. 100 (5). Oxford: Oxford University Press on behalf of the American Genetic Association: 637–647. doi:10.1093/jhered/esp048. ISSN 0022-1503. PMID 19625453. {{cite journal}}: Invalid |ref=harv (help)
133. Yampolsky, Lev Y.; Stoltzfus, Arlin (March 2001). "Bias in the introduction of variation as an orienting factor in evolution". Evolution & Development. 3 (2). Hoboken, NJ: Wiley-Blackwell on behalf of the Society for Integrative and Comparative Biology: 73–83. doi:10.1046/j.1525-142x.2001.003002073.x. ISSN 1520-541X. PMID 11341676. {{cite journal}}: Invalid |ref=harv (help)
134. Haldane, J. B. S. (January–February 1933). "The Part Played by Recurrent Mutation in Evolution". The American Naturalist. 67 (708). Chicago, IL: University of Chicago Press on behalf of the American Society of Naturalists: 5–19. doi:10.1086/280465. ISSN 0003-0147. JSTOR 2457127. {{cite journal}}: Invalid |ref=harv (help)
135. Protas, Meredith; Conrad, Melissa; Gross, Joshua B.; et al. (March 6, 2007). "Regressive Evolution in the Mexican Cave Tetra, Astyanax mexicanus". Current Biology. 17 (5). Cambridge, MA: Cell Press: 452–454. doi:10.1016/j.cub.2007.01.051. ISSN 0960-9822. PMC 2570642. PMID 17306543. {{cite journal}}: Invalid |ref=harv (help)
136. Maughan, Heather; Masel, Joanna; Birky, C. William, Jr.; Nicholson, Wayne L. (October 2007). "The Roles of Mutation Accumulation and Selection in Loss of Sporulation in Experimental Populations of Bacillus subtilis". Genetics. 177 (2). Bethesda, MD: Genetics Society of America: 937–948. doi:10.1534/genetics.107.075663. ISSN 0016-6731. PMC 2034656. PMID 17720926. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
137. Masel, Joanna; King, Oliver D.; Maughan, Heather (January 2007). "The Loss of Adaptive Plasticity during Long Periods of Environmental Stasis". The American Naturalist. 169 (1). Chicago, IL: University of Chicago Press on behalf of the American Society of Naturalists: 38–46. doi:10.1086/510212. ISSN 0003-0147. PMC 1766558. PMID 17206583. {{cite journal}}: Invalid |ref=harv (help)
138. ^ Masel, Joanna (October 25, 2011). "Genetic drift". Current Biology. 21 (20). Cambridge, MA: Cell Press: R837–R838. doi:10.1016/j.cub.2011.08.007. ISSN 0960-9822. PMID 22032182. {{cite journal}}: Invalid |ref=harv (help)
139. Lande, Russell (1989). "Fisherian and Wrightian theories of speciation". Genome. 31 (1). Ottawa: National Research Council of Canada: 221–227. doi:10.1139/g89-037. ISSN 0831-2796. PMID 2687093. {{cite journal}}: Invalid |ref=harv (help)
140. Mitchell-Olds, Thomas; Willis, John H.; Goldstein, David B. (November 2007). "Which evolutionary processes influence natural genetic variation for phenotypic traits?". Nature Reviews Genetics. 8 (11). London: Nature Publishing Group: 845–856. doi:10.1038/nrg2207. ISSN 1471-0056. PMID 17943192. {{cite journal}}: Invalid |ref=harv (help)
141. Nei, Masatoshi (December 2005). "Selectionism and Neutralism in Molecular Evolution". Molecular Biology and Evolution. 22 (12). Oxford: Oxford University Press on behalf of the Society for Molecular Biology and Evolution: 2318–2342. doi:10.1093/molbev/msi242. ISSN 0737-4038. PMC 1513187. PMID 16120807. {{cite journal}}: Invalid |ref=harv (help)
     • Nei, Masatoshi (May 2006). "Selectionism and Neutralism in Molecular Evolution" (Erratum). 23 (5). Oxford: Oxford University Press on behalf of the Society for Molecular Biology and Evolution: 1095. doi:10.1093/molbev/msk009. ISSN 0737-4038. {{cite journal}}: Cite journal requires |journal= (help)
142. Kimura, Motoo (1989). "The neutral theory of molecular evolution and the world view of the neutralists". Genome. 31 (1). Ottawa: National Research Council of Canada: 24–31. doi:10.1139/g89-009. ISSN 0831-2796. PMID 2687096. {{cite journal}}: Invalid |ref=harv (help)
143. Kreitman, Martin (August 1996). "The neutral theory is dead. Long live the neutral theory". BioEssays. 18 (8). Hoboken, NJ: John Wiley & Sons: 678–683, discussion 683. doi:10.1002/bies.950180812. ISSN 0265-9247. PMID 8760341. {{cite journal}}: Invalid |ref=harv (help)
144. Leigh, E.G., Jr. (November 2007). "Neutral theory: a historical perspective". Journal of Evolutionary Biology. 20 (6). Hoboken, NJ: Wiley-Blackwell on behalf of the European Society for Evolutionary Biology: 2075–2091. doi:10.1111/j.1420-9101.2007.01410.x. ISSN 1010-061X. PMID 17956380. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
145. ^ Gillespie, John H. (November 2001). "Is the population size of a species relevant to its evolution?". Evolution. 55 (11). Hoboken, NJ: John Wiley & Sons on behalf of the Society for the Study of Evolution: 2161–2169. doi:10.1111/j.0014-3820.2001.tb00732.x. ISSN 0014-3820. PMID 11794777. {{cite journal}}: Invalid |ref=harv (help)
146. Neher, Richard A.; Shraiman, Boris I. (August 2011). "Genetic Draft and Quasi-Neutrality in Large Facultatively Sexual Populations". Genetics. 188 (4). Bethesda, MD: Genetics Society of America: 975–996. doi:10.1534/genetics.111.128876. ISSN 0016-6731. PMC 3176096. PMID 21625002. {{cite journal}}: Invalid |ref=harv (help)
147. Otto, Sarah P.; Whitlock, Michael C. (June 1997). "The Probability of Fixation in Populations of Changing Size" (PDF). Genetics. 146 (2). Bethesda, MD: Genetics Society of America: 723–733. ISSN 0016-6731. PMC 1208011. PMID 9178020. Retrieved 2014-12-18. {{cite journal}}: Invalid |ref=harv (help)
148. ^ Charlesworth, Brian (March 2009). "Fundamental concepts in genetics: effective population size and patterns of molecular evolution and variation". Nature Reviews Genetics. 10 (3). London: Nature Publishing Group: 195–205. doi:10.1038/nrg2526. ISSN 1471-0056. PMID 19204717. {{cite journal}}: Invalid |ref=harv (help)
149. Cutter, Asher D.; Choi, Jae Young (August 2010). "Natural selection shapes nucleotide polymorphism across the genome of the nematode Caenorhabditis briggsae". Genome Research. 20 (8): 1103–1111. doi:10.1101/gr.104331.109. PMC 2909573. PMID 20508143. {{cite journal}}: Invalid |ref=harv (help)
150. Lien, Sigbjørn; Szyda, Joanna; Schechinger, Birgit; et al. (February 2000). "Evidence for Heterogeneity in Recombination in the Human Pseudoautosomal Region: High Resolution Analysis by Sperm Typing and Radiation-Hybrid Mapping". American Journal of Human Genetics. 66 (2). Cambridge, MA: Cell Press on behalf of the American Society of Human Genetics: 557–566. doi:10.1086/302754. ISSN 0002-9297. PMC 1288109. PMID 10677316. {{cite journal}}: Invalid |ref=harv (help)
151. Barton, Nicholas H. (November 29, 2000). "Genetic hitchhiking". Philosophical Transactions of the Royal Society B: Biological Sciences. 355 (1403). London: Royal Society: 1553–1562. doi:10.1098/rstb.2000.0716. ISSN 0962-8436. PMC 1692896. PMID 11127900. {{cite journal}}: Invalid |ref=harv (help)
152. Wright, Sewall (1932). "The roles of mutation, inbreeding, crossbreeding and selection in evolution". Proceedings of the VI International Congress of Genetrics. 1: 356–366. Retrieved 2014-12-18. {{cite journal}}: Invalid |ref=harv (help)
153. Coyne, Jerry A.; Barton, Nicholas H.; Turelli, Michael (June 1997). "Perspective: A Critique of Sewall Wright's Shifting Balance Theory of Evolution". Evolution. 51 (3). Hoboken, NJ: John Wiley & Sons on behalf of the Society for the Study of Evolution: 643–671. doi:10.2307/2411143. ISSN 0014-3820. {{cite journal}}: Invalid |ref=harv (help)
154. ^ Scott, Eugenie C.; Matzke, Nicholas J. (May 15, 2007). "Biological design in science classrooms". Proc. Natl. Acad. Sci. U.S.A. 104 (Suppl. 1). Washington, D.C.: National Academy of Sciences: 8669–8676. Bibcode:2007PNAS..104.8669S. doi:10.1073/pnas.0701505104. ISSN 0027-8424. PMC 1876445. PMID 17494747. {{cite journal}}: Invalid |ref=harv (help)
155. Hendry, Andrew Paul; Kinnison, Michael T. (November 2001). "An introduction to microevolution: rate, pattern, process". Genetica. 112–113. Dordrecht, the Netherlands: Kluwer Academic Publishers: 1–8. doi:10.1023/A:1013368628607. ISSN 0016-6707. PMID 11838760. {{cite journal}}: Invalid |ref=harv (help)
156. Leroi, Armand M. (March–April 2000). "The scale independence of evolution". Evolution & Development. 2 (2). Hoboken, NJ: Wiley-Blackwell on behalf of the Society for Integrative and Comparative Biology: 67–77. doi:10.1046/j.1525-142x.2000.00044.x. ISSN 1520-541X. PMID 11258392. {{cite journal}}: Invalid |ref=harv (help)
157. Gould 2002, pp. 657–658. sfn error: multiple targets (2×): CITEREFGould2002 (help)
158. ^ Gould, Stephen Jay (July 19, 1994). "Tempo and mode in the macroevolutionary reconstruction of Darwinism". Proc. Natl. Acad. Sci. U.S.A. 91 (15). Washington, D.C.: National Academy of Sciences: 6764–6771. Bibcode:1994PNAS...91.6764G. doi:10.1073/pnas.91.15.6764. ISSN 0027-8424. PMC 44281. PMID 8041695. {{cite journal}}: Invalid |ref=harv (help)
159. Jablonski, David (2000). "Micro- and macroevolution: scale and hierarchy in evolutionary biology and paleobiology". Paleobiology. 26 (sp4). Boulder, CO: Paleontological Society: 15–52. doi:10.1666/0094-8373(2000)26[15:MAMSAH]2.0.CO;2. ISSN 0094-8373. {{cite journal}}: Invalid |ref=harv (help)
160. Dougherty, Michael J. (July 20, 1998). "Is the human race evolving or devolving?". Scientific American. Stuttgart: Georg von Holtzbrinck Publishing Group. ISSN 0036-8733. {{cite journal}}: Invalid |ref=harv (help)
161. Isaak, Mark (ed.). "Claim CB932: Evolution of degenerate forms". TalkOrigins Archive. Houston, TX: The TalkOrigins Foundation, Inc. Retrieved 2014-12-19.
162. Carroll, Sean B. (February 22, 2001). "Chance and necessity: the evolution of morphological complexity and diversity". Nature. 409 (6823). London: Nature Publishing Group: 1102–1109. doi:10.1038/35059227. ISSN 0028-0836. PMID 11234024. {{cite journal}}: Invalid |ref=harv (help)
163. Whitman, William B.; Coleman, David C.; Wiebe, William J. (June 9, 1998). "Prokaryotes: The unseen majority". Proc. Natl. Acad. Sci. U.S.A. 95 (12). Washington, D.C.: National Academy of Sciences: 6578–6583. Bibcode:1998PNAS...95.6578W. doi:10.1073/pnas.95.12.6578. ISSN 0027-8424. PMC 33863. PMID 9618454. {{cite journal}}: Invalid |ref=harv (help)
164. ^ Schloss, Patrick D.; Handelsman, Jo (December 2004). "Status of the Microbial Census". Microbiology and Molecular Biology Reviews. 68 (4). Washington, D.C.: American Society for Microbiology: 686–691. doi:10.1128/MMBR.68.4.686-691.2004. ISSN 1092-2172. PMC 539005. PMID 15590780. {{cite journal}}: Invalid |ref=harv (help)
165. Nealson, Kenneth H. (January 1999). "Post-Viking microbiology: new approaches, new data, new insights". Origins of Life and Evolution of Biospheres. 29 (1). Dordrecht, the Netherlands: Kluwer Academic Publishers: 73–93. doi:10.1023/A:1006515817767. ISSN 0169-6149. PMID 11536899. {{cite journal}}: Invalid |ref=harv (help)
166. Buckling, Angus; MacLean, R. Craig; Brockhurst, Michael A.; Colegrave, Nick (February 12, 2009). "The Beagle in a bottle". Nature. 457 (7231). London: Nature Publishing Group: 824–829. Bibcode:2009Natur.457..824B. doi:10.1038/nature07892. ISSN 0028-0836. PMID 19212400. {{cite journal}}: Invalid |ref=harv (help)
167. Elena, Santiago F.; Lenski, Richard E. (June 2003). "Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation". Nature Reviews Genetics. 4 (6). London: Nature Publishing Group: 457–469. doi:10.1038/nrg1088. ISSN 1471-0056. PMID 12776215. {{cite journal}}: Invalid |ref=harv (help)
168. Mayr 1982, p. 483: "Adaptation... could no longer be considered a static condition, a product of a creative past and became instead a continuing dynamic process."
169. The sixth edition of the Oxford Dictionary of Science (2010) defines adaptation as "Any change in the structure or functioning of successive generations of a population that makes it better suited to its environment."
170. Orr, H. Allen (February 2005). "The genetic theory of adaptation: a brief history". Nature Reviews Genetics. 6 (2). London: Nature Publishing Group: 119–127. doi:10.1038/nrg1523. ISSN 1471-0056. PMID 15716908. {{cite journal}}: Invalid |ref=harv (help)
171. Dobzhansky 1968, pp. 1–34
172. Dobzhansky 1970, pp. 4–6, 79–82, 84–87
173. Dobzhansky, Theodosius (March 1956). "Genetics of Natural Populations. XXV. Genetic Changes in Populations of Drosophila pseudoobscura and Drosophila persimilis in Some Localities in California". Evolution. 10 (1). Hoboken, NJ: John Wiley & Sons on behalf of the Society for the Study of Evolution: 82–92. doi:10.2307/2406099. ISSN 0014-3820. JSTOR 2406099. {{cite journal}}: Invalid |ref=harv (help)
174. Nakajima, Akira; Sugimoto, Yohko; Yoneyama, Hiroshi; Nakae, Taiji (June 2002). "High-Level Fluoroquinolone Resistance in Pseudomonas aeruginosa Due to Interplay of the MexAB-OprM Efflux Pump and the DNA Gyrase Mutation". Microbiology and Immunology. 46 (6). Tokyo: Center for Academic Publications Japan: 391–395. doi:10.1111/j.1348-0421.2002.tb02711.x. ISSN 1348-0421. PMID 12153116. {{cite journal}}: Invalid |ref=harv (help)
175. Blount, Zachary D.; Borland, Christina Z.; Lenski, Richard E. (June 10, 2008). "Inaugural Article: Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli". Proc. Natl. Acad. Sci. U.S.A. 105 (23). Washington, D.C.: National Academy of Sciences: 7899–7906. Bibcode:2008PNAS..105.7899B. doi:10.1073/pnas.0803151105. ISSN 0027-8424. PMC 2430337. PMID 18524956. {{cite journal}}: Invalid |ref=harv (help)
176. Okada, Hirosuke; Negoro, Seiji; Kimura, Hiroyuki; Nakamura, Shunichi (November 10, 1983). "Evolutionary adaptation of plasmid-encoded enzymes for degrading nylon oligomers". Nature. 306 (5939). London: Nature Publishing Group: 203–206. Bibcode:1983Natur.306..203O. doi:10.1038/306203a0. ISSN 0028-0836. PMID 6646204. {{cite journal}}: Invalid |ref=harv (help)
177. Ohno, Susumu (April 1984). "Birth of a unique enzyme from an alternative reading frame of the preexisted, internally repetitious coding sequence". Proc. Natl. Acad. Sci. U.S.A. 81 (8). Washington, D.C.: National Academy of Sciences: 2421–2425. Bibcode:1984PNAS...81.2421O. doi:10.1073/pnas.81.8.2421. ISSN 0027-8424. PMC 345072. PMID 6585807. {{cite journal}}: Invalid |ref=harv (help)
178. Copley, Shelley D. (June 2000). "Evolution of a metabolic pathway for degradation of a toxic xenobiotic: the patchwork approach". Trends in Biochemical Sciences. 25 (6). Cambridge, MA: Cell Press: 261–265. doi:10.1016/S0968-0004(00)01562-0. ISSN 0968-0004. PMID 10838562. {{cite journal}}: Invalid |ref=harv (help)
179. Crawford, Ronald L.; Jung, Carina M.; Strap, Janice L. (October 2007). "The recent evolution of pentachlorophenol (PCP)-4-monooxygenase (PcpB) and associated pathways for bacterial degradation of PCP". Biodegradation (journal). 18 (5). Dordrecht, the Netherlands: Springer Netherlands: 525–539. doi:10.1007/s10532-006-9090-6. ISSN 0923-9820. PMID 17123025. {{cite journal}}: Cite has empty unknown parameter: |1= (help); Invalid |ref=harv (help)
180. Eshel, Ilan (December 1973). "Clone-Selection and Optimal Rates of Mutation". Journal of Applied Probability. 10 (4). Sheffield, England: 728–738. doi:10.2307/3212376. ISSN 1475-6072. JSTOR 3212376. {{cite journal}}: Invalid |ref=harv (help)
181. Altenberg 1995, pp. 205–259
182. Masel, Joanna; Bergman, Aviv (July 2003). "The evolution of the evolvability properties of the yeast prion ". Evolution. 57 (7). Hoboken, NJ: John Wiley & Sons on behalf of the Society for the Study of Evolution: 1498–1512. doi:10.1111/j.0014-3820.2003.tb00358.x. ISSN 0014-3820. PMID 12940355. {{cite journal}}: Invalid |ref=harv (help)
183. Lancaster, Alex K.; Bardill, J. Patrick; True, Heather L.; Masel, Joanna (February 2010). "The Spontaneous Appearance Rate of the Yeast Prion [PSI+] and Its Implications for the Evolution of the Evolvability Properties of the [PSI+] System". Genetics. 184 (2). Bethesda, MD: Genetics Society of America: 393–400. doi:10.1534/genetics.109.110213. ISSN 0016-6731. PMC 2828720. PMID 19917766. {{cite journal}}: Invalid |ref=harv (help)
184. Draghi, Jeremy; Wagner, Günter P. (February 2008). "Evolution of evolvability in a developmental model". Evolution. 62 (2). Hoboken, NJ: John Wiley & Sons on behalf of the Society for the Study of Evolution: 301–315. doi:10.1111/j.1558-5646.2007.00303.x. ISSN 0014-3820. PMID 18031304. {{cite journal}}: Invalid |ref=harv (help)
185. ^ Bejder L, Hall BK (2002). "Limbs in whales and limblessness in other vertebrates: mechanisms of evolutionary and developmental transformation and loss". Evol. Dev. 4 (6): 445–58. doi:10.1046/j.1525-142X.2002.02033.x. PMID 12492145. {{cite journal}}: Invalid |ref=harv (help)
186. Young, Nathan M.; Hallgrímsson, B (2005). "Serial homology and the evolution of mammalian limb covariation structure". Evolution. 59 (12): 2691–704. doi:10.1554/05-233.1. PMID 16526515. {{cite journal}}: Invalid |ref=harv (help)
187. ^ Penny D, Poole A (1999). "The nature of the last universal common ancestor". Current Opinion in Genetics & Development. 9 (6): 672–77. doi:10.1016/S0959-437X(99)00020-9. PMID 10607605. {{cite journal}}: Invalid |ref=harv (help)
188. Hall, Brian K (2003). "Descent with modification: the unity underlying homology and homoplasy as seen through an analysis of development and evolution". Biological Reviews of the Cambridge Philosophical Society. 78 (3): 409–433. doi:10.1017/S1464793102006097. PMID 14558591. {{cite journal}}: Invalid |ref=harv (help)
189. Shubin, Neil; Tabin, C; Carroll, S (2009). "Deep homology and the origins of evolutionary novelty". Nature. 457 (7231): 818–823. Bibcode:2009Natur.457..818S. doi:10.1038/nature07891. PMID 19212399. {{cite journal}}: Invalid |ref=harv (help)
190. ^ Fong D, Kane T, Culver D (1995). "Vestigialisation and Loss of Nonfunctional Characters". Ann. Rev. Ecol. Syst. 26 (4): 249–68. doi:10.1146/annurev.es.26.110195.001341. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
191. Zhang Z, Gerstein M (2004). "Large-scale analysis of pseudogenes in the human genome". Current Opinion in Genetics & Development. 14 (4): 328–35. doi:10.1016/j.gde.2004.06.003. PMID 15261647. {{cite journal}}: Invalid |ref=harv (help)
192. Jeffery WR (2005). "Adaptive evolution of eye degeneration in the Mexican blind cavefish". J. Hered. 96 (3): 185–96. doi:10.1093/jhered/esi028. PMID 15653557. {{cite journal}}: Invalid |ref=harv (help)
193. Maxwell EE, Larsson HC (2007). "Osteology and myology of the wing of the Emu (Dromaius novaehollandiae) and its bearing on the evolution of vestigial structures". J. Morphol. 268 (5): 423–41. doi:10.1002/jmor.10527. PMID 17390336. {{cite journal}}: Invalid |ref=harv (help)
194. Silvestri AR, Singh I (2003). "The unresolved problem of the third molar: would people be better off without it?". Journal of the American Dental Association (1939). 134 (4): 450–5. doi:10.14219/jada.archive.2003.0194. PMID 12733778. {{cite journal}}: Invalid |ref=harv (help)
195. Coyne, Jerry A. (2009). Why Evolution is True. Penguin Group. p. 62. ISBN 978-0-670-02053-9.
196. Darwin, Charles. (1872) The Expression of the Emotions in Man and Animals John Murray, London.
197. Peter Gray (2007). Psychology (fifth ed.). Worth Publishers. p. 66. ISBN 0-7167-0617-2.
198. Coyne, Jerry A. (2009). Why Evolution Is True. Penguin Group. pp. 85–86. ISBN 978-0-670-02053-9.
199. Anthony Stevens (1982). Archetype: A Natural History of the Self. Routledge & Kegan Paul. p. 87. ISBN 0-7100-0980-1.
200. ^ Gould 2002, pp. 1235–1236. sfn error: multiple targets (2×): CITEREFGould2002 (help)
201. Pallen, Mark J.; Matzke, NJ (October 2006). "From The Origin of Species to the origin of bacterial flagella" (PDF). Nature Reviews Microbiology. 4 (10): 784–790. doi:10.1038/nrmicro1493. PMID 16953248. Retrieved September 18, 2009. {{cite journal}}: Invalid |ref=harv (help)
202. Clements, Abigail; Bursac, D; Gatsos, X; Perry, AJ; Civciristov, S; Celik, N; Likic, VA; Poggio, S; Jacobs-Wagner, C; Strugnell, RA; Lithgow, T (2009). "The reducible complexity of a mitochondrial molecular machine". Proceedings of the National Academy of Sciences. 106 (37): 15791–15795. Bibcode:2009PNAS..10615791C. doi:10.1073/pnas.0908264106. PMC 2747197. PMID 19717453. {{cite journal}}: Invalid |ref=harv (help)
203. Piatigorsky J, Kantorow M, Gopal-Srivastava R, Tomarev SI (1994). "Recruitment of enzymes and stress proteins as lens crystallins". EXS. 71: 241–50. doi:10.1007/978-3-0348-7330-7_24. PMID 8032155. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
204. Wistow G (1993). "Lens crystallins: gene recruitment and evolutionary dynamism". Trends Biochem. Sci. 18 (8): 301–6. doi:10.1016/0968-0004(93)90041-K. PMID 8236445. {{cite journal}}: Invalid |ref=harv (help)
205. Johnson NA, Porter AH (2001). "Toward a new synthesis: population genetics and evolutionary developmental biology". Genetica. 112–113: 45–58. doi:10.1023/A:1013371201773. PMID 11838782. {{cite journal}}: Invalid |ref=harv (help)
206. Baguñà J, Garcia-Fernàndez J (2003). "Evo-Devo: the long and winding road". Int. J. Dev. Biol. 47 (7–8): 705–13. PMID 14756346. {{cite journal}}: Invalid |ref=harv (help)
     *Love AC. (2003). "Evolutionary Morphology, Innovation and the Synthesis of Evolutionary and Developmental Biology". Biology and Philosophy. 18 (2): 309–345. doi:10.1023/A:1023940220348. {{cite journal}}: Invalid |ref=harv (help)
207. Allin EF (1975). "Evolution of the mammalian middle ear". J. Morphol. 147 (4): 403–37. doi:10.1002/jmor.1051470404. PMID 1202224. {{cite journal}}: Invalid |ref=harv (help)
208. Harris MP, Hasso SM, Ferguson MW, Fallon JF (2006). "The development of archosaurian first-generation teeth in a chicken mutant". Curr. Biol. 16 (4): 371–7. doi:10.1016/j.cub.2005.12.047. PMID 16488870. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
209. Carroll SB (2008). "Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution". Cell. 134 (1): 25–36. doi:10.1016/j.cell.2008.06.030. PMID 18614008. {{cite journal}}: Invalid |ref=harv (help)
210. Wade MJ (2007). "The co-evolutionary genetics of ecological communities". Nature Reviews Genetics. 8 (3): 185–95. doi:10.1038/nrg2031. PMID 17279094. {{cite journal}}: Invalid |ref=harv (help)
211. Geffeney S, Brodie ED, Ruben PC, Brodie ED (2002). "Mechanisms of adaptation in a predator-prey arms race: TTX-resistant sodium channels". Science. 297 (5585): 1336–9. Bibcode:2002Sci...297.1336G. doi:10.1126/science.1074310. PMID 12193784. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
     *Brodie ED, Ridenhour BJ, Brodie ED (2002). "The evolutionary response of predators to dangerous prey: hotspots and coldspots in the geographic mosaic of coevolution between garter snakes and newts". Evolution. 56 (10): 2067–82. doi:10.1554/0014-3820(2002)056[2067:teropt]2.0.co;2. PMID 12449493. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
     *Sean B. Carroll (December 21, 2009). "Remarkable Creatures – Clues to Toxins in Deadly Delicacies of the Animal Kingdom". New York Times.
212. Sachs J (2006). "Cooperation within and among species". J. Evol. Biol. 19 (5): 1415–8, discussion 1426–36. doi:10.1111/j.1420-9101.2006.01152.x. PMID 16910971. {{cite journal}}: Invalid |ref=harv (help)
     *Nowak M (2006). "Five rules for the evolution of cooperation". Science. 314 (5805): 1560–3. Bibcode:2006Sci...314.1560N. doi:10.1126/science.1133755. PMC 3279745. PMID 17158317. {{cite journal}}: Invalid |ref=harv (help)
213. Paszkowski U (2006). "Mutualism and parasitism: the yin and yang of plant symbioses". Current Opinion in Plant Biology. 9 (4): 364–70. doi:10.1016/j.pbi.2006.05.008. PMID 16713732. {{cite journal}}: Invalid |ref=harv (help)
214. Hause B, Fester T (2005). "Molecular and cell biology of arbuscular mycorrhizal symbiosis". Planta. 221 (2): 184–96. doi:10.1007/s00425-004-1436-x. PMID 15871030. {{cite journal}}: Invalid |ref=harv (help)
215. Bertram J (2000). "The molecular biology of cancer". Mol. Aspects Med. 21 (6): 167–223. doi:10.1016/S0098-2997(00)00007-8. PMID 11173079. {{cite journal}}: Invalid |ref=harv (help)
216. Reeve HK, Hölldobler B (2007). "The emergence of a superorganism through intergroup competition". Proc Natl Acad Sci U S A. 104 (23): 9736–40. Bibcode:2007PNAS..104.9736R. doi:10.1073/pnas.0703466104. PMC 1887545. PMID 17517608. {{cite journal}}: Invalid |ref=harv (help)
217. Axelrod R, Hamilton W (2005). "The evolution of cooperation". Science. 211 (4489): 1390–6. Bibcode:1981Sci...211.1390A. doi:10.1126/science.7466396. PMID 7466396. {{cite journal}}: Invalid |ref=harv (help)
218. Wilson EO, Hölldobler B (2005). "Eusociality: origin and consequences". Proc. Natl. Acad. Sci. U.S.A. 102 (38): 13367–71. Bibcode:2005PNAS..10213367W. doi:10.1073/pnas.0505858102. PMC 1224642. PMID 16157878. {{cite journal}}: Invalid |ref=harv (help)
219. ^ Gavrilets S (2003). "Perspective: models of speciation: what have we learned in 40 years?". Evolution. 57 (10): 2197–215. doi:10.1554/02-727. PMID 14628909. {{cite journal}}: Invalid |ref=harv (help)
220. ^ de Queiroz K (2005). "Ernst Mayr and the modern concept of species". Proc. Natl. Acad. Sci. U.S.A. 102 (Suppl 1): 6600–7. Bibcode:2005PNAS..102.6600D. doi:10.1073/pnas.0502030102. PMC 1131873. PMID 15851674. {{cite journal}}: Invalid |ref=harv (help)
221. ^ Ereshefsky, M. (1992). "Eliminative pluralism". Philosophy of Science. 59 (4): 671–690. doi:10.1086/289701. JSTOR 188136.
222. Mayr, E. (1942). Systematics and the Origin of Species. New York: Columbia Univ. Press. p. 120. ISBN 978-0-231-05449-2.
223. Fraser C, Alm EJ, Polz MF, Spratt BG, Hanage WP (2009). "The bacterial species challenge: making sense of genetic and ecological diversity". Science. 323 (5915): 741–6. Bibcode:2009Sci...323..741F. doi:10.1126/science.1159388. PMID 19197054. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
224. Short RV (1975). "The contribution of the mule to scientific thought". J. Reprod. Fertil. Suppl. (23): 359–64. PMID 1107543. {{cite journal}}: Invalid |ref=harv (help)
225. Gross B, Rieseberg L (2005). "The ecological genetics of homoploid hybrid speciation". J. Hered. 96 (3): 241–52. doi:10.1093/jhered/esi026. PMC 2517139. PMID 15618301. {{cite journal}}: Invalid |ref=harv (help)
226. Burke JM, Arnold ML (2001). "Genetics and the fitness of hybrids". Annu. Rev. Genet. 35 (1): 31–52. doi:10.1146/annurev.genet.35.102401.085719. PMID 11700276. {{cite journal}}: Invalid |ref=harv (help)
227. Vrijenhoek RC (2006). "Polyploid hybrids: multiple origins of a treefrog species". Curr. Biol. 16 (7): R245–7. doi:10.1016/j.cub.2006.03.005. PMID 16581499. {{cite journal}}: Invalid |ref=harv (help)
228. Rice, W.R.; Hostert (1993). "Laboratory experiments on speciation: what have we learned in 40 years". Evolution. 47 (6): 1637–1653. doi:10.2307/2410209. {{cite journal}}: Invalid |ref=harv (help)
     *Jiggins CD, Bridle JR (2004). "Speciation in the apple maggot fly: a blend of vintages?". Trends Ecol. Evol. (Amst.). 19 (3): 111–4. doi:10.1016/j.tree.2003.12.008. PMID 16701238. {{cite journal}}: Invalid |ref=harv (help)
     *Boxhorn, J (1995). "Observed Instances of Speciation". TalkOrigins Archive. Retrieved December 26, 2008.
     *Weinberg JR, Starczak VR, Jorg, D (1992). "Evidence for Rapid Speciation Following a Founder Event in the Laboratory". Evolution. 46 (4): 1214–20. doi:10.2307/2409766. JSTOR 2409766. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
229. Herrel, A.; Huyghe, K.; Vanhooydonck, B.; Backeljau, T.; Breugelmans, K.; Grbac, I.; Van Damme, R.; Irschick, D.J. (2008). "Rapid large-scale evolutionary divergence in morphology and performance associated with exploitation of a different dietary resource". Proceedings of the National Academy of Sciences. 105 (12): 4792–5. Bibcode:2008PNAS..105.4792H. doi:10.1073/pnas.0711998105. PMC 2290806. PMID 18344323. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
230. Losos, J.B. Warhelt, K.I. Schoener, T.W. (1997). "Adaptive differentiation following experimental island colonization in Anolis lizards". Nature. 387 (6628): 70–3. Bibcode:1997Natur.387...70L. doi:10.1038/387070a0. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
231. Hoskin CJ, Higgle M, McDonald KR, Moritz C (2005). "Reinforcement drives rapid allopatric speciation". Nature. 437 (7063): 1353–356. Bibcode:2005Natur.437.1353H. doi:10.1038/nature04004. PMID 16251964. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
232. Templeton AR (April 1, 1980). "The theory of speciation via the founder principle". Genetics. 94 (4): 1011–38. PMC 1214177. PMID 6777243. {{cite journal}}: Invalid |ref=harv (help)
233. Antonovics J (2006). "Evolution in closely adjacent plant populations X: long-term persistence of prereproductive isolation at a mine boundary". Heredity. 97 (1): 33–7. doi:10.1038/sj.hdy.6800835. PMID 16639420. {{cite journal}}: Invalid |ref=harv (help)
234. Nosil P, Crespi B, Gries R, Gries G (2007). "Natural selection and divergence in mate preference during speciation". Genetica. 129 (3): 309–27. doi:10.1007/s10709-006-0013-6. PMID 16900317. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
235. Savolainen V, Anstett M-C, Lexer C, Hutton I, Clarkson JJ, Norup MV, Powell MP, Springate D, Salamin N, Baker WJr (2006). "Sympatric speciation in palms on an oceanic island". Nature. 441 (7090): 210–3. Bibcode:2006Natur.441..210S. doi:10.1038/nature04566. PMID 16467788. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
     *Barluenga M, Stölting KN, Salzburger W, Muschick M, Meyer A (2006). "Sympatric speciation in Nicaraguan crater lake cichlid fish". Nature. 439 (7077): 719–23. Bibcode:2006Natur.439..719B. doi:10.1038/nature04325. PMID 16467837. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
236. Gavrilets S (2006). "The Maynard Smith model of sympatric speciation". J. Theor. Biol. 239 (2): 172–82. doi:10.1016/j.jtbi.2005.08.041. PMID 16242727. {{cite journal}}: Invalid |ref=harv (help)
237. Wood TE, Takebayashi N, Barker MS, Mayrose I, Greenspoon PB, Rieseberg LH (2009). "The frequency of polyploid speciation in vascular plants". Proc. Natl. Acad. Sci. U.S.A. 106 (33): 13875–9. Bibcode:2009PNAS..10613875W. doi:10.1073/pnas.0811575106. PMC 2728988. PMID 19667210. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
238. Hegarty Mf, Hiscock SJ (2008). "Genomic clues to the evolutionary success of polyploid plants". Current Biology. 18 (10): 435–44. doi:10.1016/j.cub.2008.03.043. PMID 18492478. {{cite journal}}: Invalid |ref=harv (help)
239. Jakobsson M, Hagenblad J, Tavaré S (2006). "A unique recent origin of the allotetraploid species Arabidopsis suecica: Evidence from nuclear DNA markers". Mol. Biol. Evol. 23 (6): 1217–31. doi:10.1093/molbev/msk006. PMID 16549398. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
240. Säll T, Jakobsson M, Lind-Halldén C, Halldén C (2003). "Chloroplast DNA indicates a single origin of the allotetraploid Arabidopsis suecica". J. Evol. Biol. 16 (5): 1019–29. doi:10.1046/j.1420-9101.2003.00554.x. PMID 14635917. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
241. Bomblies K, Weigel D (2007). "Arabidopsis-a model genus for speciation". Current Opinion in Genetics & Development. 17 (6): 500–4. doi:10.1016/j.gde.2007.09.006. PMID 18006296. {{cite journal}}: Invalid |ref=harv (help)
242. Sémon M, Wolfe KH (2007). "Consequences of genome duplication". Current Opinion in Genetics & Development. 17 (6): 505–12. doi:10.1016/j.gde.2007.09.007. PMID 18006297. {{cite journal}}: Invalid |ref=harv (help)
243. Niles Eldredge and Stephen Jay Gould, 1972. "Punctuated equilibria: an alternative to phyletic gradualism" In T.J.M. Schopf, ed., Models in Paleobiology. San Francisco: Freeman Cooper. pp. 82–115. Reprinted in N. Eldredge Time frames. Princeton: Princeton Univ. Press. 1985
244. Benton MJ (1995). "Diversification and extinction in the history of life". Science. 268 (5207): 52–8. Bibcode:1995Sci...268...52B. doi:10.1126/science.7701342. PMID 7701342. {{cite journal}}: Invalid |ref=harv (help)
245. Raup DM (1986). "Biological extinction in Earth history". Science. 231 (4745): 1528–33. Bibcode:1986Sci...231.1528R. doi:10.1126/science.11542058. PMID 11542058. {{cite journal}}: Invalid |ref=harv (help)
246. Avise, John C.; Hubbell, Stephen P.; Ayala, Francisco J. (August 12, 2008). "In the light of evolution II: Biodiversity and extinction". Proc. Natl. Acad. Sci. U.S.A. 105 (Suppl. 1): 11453–11457. Bibcode:2008PNAS..10511453A. doi:10.1073/pnas.0802504105. ISSN 0027-8424. PMC 2556414. PMID 18695213. {{cite journal}}: Invalid |ref=harv (help)
247. ^ Raup DM (1994). "The role of extinction in evolution". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 6758–63. Bibcode:1994PNAS...91.6758R. doi:10.1073/pnas.91.15.6758. PMC 44280. PMID 8041694. {{cite journal}}: Invalid |ref=harv (help)
248. Novacek MJ, Cleland EE (2001). "The current biodiversity extinction event: scenarios for mitigation and recovery". Proc. Natl. Acad. Sci. U.S.A. 98 (10): 5466–70. Bibcode:2001PNAS...98.5466N. doi:10.1073/pnas.091093698. PMC 33235. PMID 11344295. {{cite journal}}: Invalid |ref=harv (help)
249. Pimm S, Raven P, Peterson A, Sekercioglu CH, Ehrlich PR (2006). "Human impacts on the rates of recent, present and future bird extinctions". Proc. Natl. Acad. Sci. U.S.A. 103 (29): 10941–6. Bibcode:2006PNAS..10310941P. doi:10.1073/pnas.0604181103. PMC 1544153. PMID 16829570. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
     *Barnosky AD, Koch PL, Feranec RS, Wing SL, Shabel AB (2004). "Assessing the causes of late Pleistocene extinctions on the continents". Science. 306 (5693): 70–5. Bibcode:2004Sci...306...70B. doi:10.1126/science.1101476. PMID 15459379. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
250. Lewis OT (2006). "Climate change, species-area curves and the extinction crisis". Philosophical Transactions of the Royal Society B. 361 (1465): 163–71. doi:10.1098/rstb.2005.1712. PMC 1831839. PMID 16553315. {{cite journal}}: Invalid |ref=harv (help)
251. Jablonski D (2001). "Lessons from the past: evolutionary impacts of mass extinctions". Proc. Natl. Acad. Sci. U.S.A. 98 (10): 5393–8. Bibcode:2001PNAS...98.5393J. doi:10.1073/pnas.101092598. PMC 33224. PMID 11344284. {{cite journal}}: Invalid |ref=harv (help)
252. Peretó J (2005). "Controversies on the origin of life" (PDF). Int. Microbiol. 8 (1): 23–31. PMID 15906258. {{cite journal}}: Invalid |ref=harv (help)
253. Joyce GF (2002). "The antiquity of RNA-based evolution". Nature. 418 (6894): 214–21. Bibcode:2002Natur.418..214J. doi:10.1038/418214a. PMID 12110897. {{cite journal}}: Invalid |ref=harv (help)
254. Trevors JT, Psenner R (2001). "From self-assembly of life to present-day bacteria: a possible role for nanocells". FEMS Microbiol. Rev. 25 (5): 573–82. doi:10.1111/j.1574-6976.2001.tb00592.x. PMID 11742692. {{cite journal}}: Invalid |ref=harv (help)
255. Theobald, DL. (2010). "A formal test of the theory of universal common ancestry". Nature. 465 (7295): 219–22. Bibcode:2010Natur.465..219T. doi:10.1038/nature09014. PMID 20463738. {{cite journal}}: Invalid |ref=harv (help)
256. Bapteste E, Walsh DA (2005). "Does the 'Ring of Life' ring true?". Trends Microbiol. 13 (6): 256–61. doi:10.1016/j.tim.2005.03.012. PMID 15936656. {{cite journal}}: Invalid |ref=harv (help)
257. Darwin 1859, p. 1
258. Doolittle WF, Bapteste E (2007). "Pattern pluralism and the Tree of Life hypothesis". Proc. Natl. Acad. Sci. U.S.A. 104 (7): 2043–9. Bibcode:2007PNAS..104.2043D. doi:10.1073/pnas.0610699104. PMC 1892968. PMID 17261804. {{cite journal}}: Invalid |ref=harv (help)
259. Kunin V, Goldovsky L, Darzentas N, Ouzounis CA (2005). "The net of life: reconstructing the microbial phylogenetic network". Genome Res. 15 (7): 954–9. doi:10.1101/gr.3666505. PMC 1172039. PMID 15965028. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
260. Jablonski D (1999). "The future of the fossil record". Science. 284 (5423): 2114–16. doi:10.1126/science.284.5423.2114. PMID 10381868. {{cite journal}}: Invalid |ref=harv (help)
261. Mason SF (1984). "Origins of biomolecular handedness". Nature. 311 (5981): 19–23. Bibcode:1984Natur.311...19M. doi:10.1038/311019a0. PMID 6472461. {{cite journal}}: Invalid |ref=harv (help)
262. Wolf YI, Rogozin IB, Grishin NV, Koonin EV (2002). "Genome trees and the tree of life". Trends Genet. 18 (9): 472–79. doi:10.1016/S0168-9525(02)02744-0. PMID 12175808. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
263. Varki A, Altheide TK (2005). "Comparing the human and chimpanzee genomes: searching for needles in a haystack". Genome Res. 15 (12): 1746–58. doi:10.1101/gr.3737405. PMID 16339373. {{cite journal}}: Invalid |ref=harv (help)
264. Ciccarelli FD, Doerks T, von Mering C, Creevey CJ, Snel B, Bork P (2006). "Toward automatic reconstruction of a highly resolved tree of life". Science. 311 (5765): 1283–87. Bibcode:2006Sci...311.1283C. doi:10.1126/science.1123061. PMID 16513982. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
265. ^ Cavalier-Smith T (2006). "Cell evolution and Earth history: stasis and revolution". Philosophical Transactions of the Royal Society B. 361 (1470): 969–1006. doi:10.1098/rstb.2006.1842. PMC 1578732. PMID 16754610. {{cite journal}}: Invalid |ref=harv (help)
266. Schopf J (2006). "Fossil evidence of Archaean life". Philosophical Transactions of the Royal Society B. 361 (1470): 869–85. doi:10.1098/rstb.2006.1834. PMC 1578735. PMID 16754604. {{cite journal}}: Invalid |ref=harv (help)
     *Altermann W, Kazmierczak J (2003). "Archean microfossils: a reappraisal of early life on Earth". Res Microbiol. 154 (9): 611–17. doi:10.1016/j.resmic.2003.08.006. PMID 14596897. {{cite journal}}: Invalid |ref=harv (help)
267. Schopf J (1994). "Disparate rates, differing fates: tempo and mode of evolution changed from the Precambrian to the Phanerozoic". Proc Natl Acad Sci U S A. 91 (15): 6735–42. Bibcode:1994PNAS...91.6735S. doi:10.1073/pnas.91.15.6735. PMC 44277. PMID 8041691. {{cite journal}}: Invalid |ref=harv (help)
268. Poole A, Penny D (2007). "Evaluating hypotheses for the origin of eukaryotes". BioEssays. 29 (1): 74–84. doi:10.1002/bies.20516. PMID 17187354. {{cite journal}}: Invalid |ref=harv (help)
269. Dyall S, Brown M, Johnson P (2004). "Ancient invasions: from endosymbionts to organelles". Science. 304 (5668): 253–57. Bibcode:2004Sci...304..253D. doi:10.1126/science.1094884. PMID 15073369. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
270. Martin W (2005). "The missing link between hydrogenosomes and mitochondria". Trends Microbiol. 13 (10): 457–59. doi:10.1016/j.tim.2005.08.005. PMID 16109488. {{cite journal}}: Invalid |ref=harv (help)
271. Lang B, Gray M, Burger G (1999). "Mitochondrial genome evolution and the origin of eukaryotes". Annu Rev Genet. 33 (1): 351–97. doi:10.1146/annurev.genet.33.1.351. PMID 10690412. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
     *McFadden G (1999). "Endosymbiosis and evolution of the plant cell". Current Opinion in Plant Biology. 2 (6): 513–19. doi:10.1016/S1369-5266(99)00025-4. PMID 10607659. {{cite journal}}: Invalid |ref=harv (help)
272. DeLong E, Pace N (2001). "Environmental diversity of bacteria and archaea". Syst Biol. 50 (4): 470–8. doi:10.1080/106351501750435040. PMID 12116647. {{cite journal}}: Invalid |ref=harv (help)
273. Kaiser D (2001). "Building a multicellular organism". Annu. Rev. Genet. 35 (1): 103–23. doi:10.1146/annurev.genet.35.102401.090145. PMID 11700279. {{cite journal}}: Invalid |ref=harv (help)
274. Valentine JW, Jablonski D, Erwin DH (March 1, 1999). "Fossils, molecules and embryos: new perspectives on the Cambrian explosion". Development. 126 (5): 851–9. PMID 9927587. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
275. Ohno S (1997). "The reason for as well as the consequence of the Cambrian explosion in animal evolution". J. Mol. Evol. 44. 1 (S1): S23–7. doi:10.1007/PL00000055. PMID 9071008. {{cite journal}}: Invalid |ref=harv (help)
     *Valentine J, Jablonski D (2003). "Morphological and developmental macroevolution: a paleontological perspective". Int. J. Dev. Biol. 47 (7–8): 517–22. PMID 14756327. {{cite journal}}: Invalid |ref=harv (help)
276. Waters ER (2003). "Molecular adaptation and the origin of land plants". Mol. Phylogenet. Evol. 29 (3): 456–63. doi:10.1016/j.ympev.2003.07.018. PMID 14615186. {{cite journal}}: Invalid |ref=harv (help)
277. Mayhew PJ (2007). "Why are there so many insect species? Perspectives from fossils and phylogenies". Biol Rev Camb Philos Soc. 82 (3): 425–54. doi:10.1111/j.1469-185X.2007.00018.x. PMID 17624962. {{cite journal}}: Invalid |ref=harv (help)
278. Carroll, Robert L. (May 2007). "The Palaeozoic Ancestry of Salamanders, Frogs and Caecilians". Zool J Linn Soc. 150 (s1): 1–140. doi:10.1111/j.1096-3642.2007.00246.x. PMID 12752770. {{cite journal}}: Invalid |ref=harv (help)
279. Wible JR, Rougier GW, Novacek MJ, Asher RJ (2007). "Cretaceous eutherians and Laurasian origin for placental mammals near the K/T boundary". Nature. 447 (7147): 1003–1006. Bibcode:2007Natur.447.1003W. doi:10.1038/nature05854. PMID 17581585. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
280. Witmer LM (2011). "Palaeontology: An icon knocked from its perch". Nature. 475 (7357): 458–459. doi:10.1038/475458a. PMID 21796198. {{cite journal}}: Invalid |ref=harv (help)
281. Bull JJ, Wichman HA (2001). "Applied evolution". Annu Rev Ecol Syst. 32 (1): 183–217. doi:10.1146/annurev.ecolsys.32.081501.114020. {{cite journal}}: Invalid |ref=harv (help)
282. Doebley JF, Gaut BS, Smith BD (2006). "The molecular genetics of crop domestication". Cell. 127 (7): 1309–21. doi:10.1016/j.cell.2006.12.006. PMID 17190597. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
283. Jäckel C, Kast P, Hilvert D (2008). "Protein design by directed evolution". Annu Rev Biophys. 37 (1): 153–73. doi:10.1146/annurev.biophys.37.032807.125832. PMID 18573077. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
284. Maher B. (2009). "Evolution: Biology's next top model?". Nature. 458 (7239): 695–8. doi:10.1038/458695a. PMID 19360058. {{cite journal}}: Invalid |ref=harv (help)
285. Borowsky R (2008). "Restoring sight in blind cavefish". Curr. Biol. 18 (1): R23–4. doi:10.1016/j.cub.2007.11.023. PMID 18177707. {{cite journal}}: Invalid |ref=harv (help)
286. Gross JB, Borowsky R, Tabin CJ (2009). Barsh, Gregory S. (ed.). "A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the cavefish Astyanax mexicanus". PLoS Genet. 5 (1): e1000326. doi:10.1371/journal.pgen.1000326. PMC 2603666. PMID 19119422. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
287. Merlo, LM; Pepper, JW; Reid, BJ; Maley, CC (Dec 2006). "Cancer as an evolutionary and ecological process". Nature reviews. Cancer. 6 (12): 924–35. doi:10.1038/nrc2013. PMID 17109012.
288. Pan, D; Xue, W; Zhang, W; Liu, H; Yao, X (Oct 2012). "Understanding the drug resistance mechanism of hepatitis C virus NS3/4A to ITMN-191 due to R155K, A156V, D168A/E mutations: a computational study". Biochimica et Biophysica Acta. 1820 (10): 1526–34. doi:10.1016/j.bbagen.2012.06.001. PMID 22698669.
289. Woodford, N; Ellington, MJ (Jan 2007). "The emergence of antibiotic resistance by mutation". Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 13 (1): 5–18. doi:10.1111/j.1469-0691.2006.01492.x. PMID 17184282.
290. Labbé, P; Berticat, C; Berthomieu, A; Unal, S; Bernard, C; Weill, M; Lenormand, T (Nov 2007). "Forty years of erratic insecticide resistance evolution in the mosquito Culex pipiens". PLoS genetics. 3 (11): e205. doi:10.1371/journal.pgen.0030205. PMID 18020711.{{cite journal}}: CS1 maint: unflagged free DOI (link)
291. NEVE, P (October 2007). "Challenges for herbicide resistance evolution and management: 50 years after Harper". Weed Research. 47 (5): 365–369. doi:10.1111/j.1365-3180.2007.00581.x.
292. Rodríguez-Rojas, A; Rodríguez-Beltrán, J; Couce, A; Blázquez, J (Aug 2013). "Antibiotics and antibiotic resistance: a bitter fight against evolution". International journal of medical microbiology : IJMM. 303 (6–7): 293–7. doi:10.1016/j.ijmm.2013.02.004. PMID 23517688.
293. Schenk, MF; Szendro, IG; Krug, J; de Visser, JA (Jun 2012). "Quantifying the adaptive potential of an antibiotic resistance enzyme". PLoS genetics. 8 (6): e1002783. doi:10.1371/journal.pgen.1002783. PMID 22761587.{{cite journal}}: CS1 maint: unflagged free DOI (link)
294. Read, AF; Lynch, PA; Thomas, MB (Apr 7, 2009). "How to make evolution-proof insecticides for malaria control". PLoS Biology. 7 (4): e1000058. doi:10.1371/journal.pbio.1000058. PMID 19355786.{{cite journal}}: CS1 maint: unflagged free DOI (link)
295. Fraser AS (1958). "Monte Carlo analyses of genetic models". Nature. 181 (4603): 208–9. Bibcode:1958Natur.181..208F. doi:10.1038/181208a0. PMID 13504138. {{cite journal}}: Invalid |ref=harv (help)
296. Rechenberg, Ingo (1973). Evolutionsstrategie – Optimierung technischer Systeme nach Prinzipien der biologischen Evolution (PhD thesis) (in German). Fromman-Holzboog.
297. Holland, John H. (1975). Adaptation in Natural and Artificial Systems. University of Michigan Press. ISBN 0-262-58111-6.
298. Koza, John R. (1992). Genetic Programming: On the Programming of Computers by Means of Natural Selection. MIT Press. ISBN 0-262-11170-5.
299. Jamshidi M (2003). "Tools for intelligent control: fuzzy controllers, neural networks and genetic algorithms". Philosophical Transactions of the Royal Society A. 361 (1809): 1781–808. Bibcode:2003RSPTA.361.1781J. doi:10.1098/rsta.2003.1225. PMID 12952685. {{cite journal}}: Invalid |ref=harv (help)
300. Browne, Janet (2003). Charles Darwin: The Power of Place. London: Pimlico. pp. 376–379. ISBN 0-7126-6837-3.
301. For an overview of the philosophical, religious and cosmological controversies, see: Dennett, D (1995). Darwin's Dangerous Idea: Evolution and the Meanings of Life. Simon & Schuster. ISBN 978-0-684-82471-0.
     *For the scientific and social reception of evolution in the 19th and early 20th centuries, see: Johnston, Ian C. "History of Science: Origins of Evolutionary Theory". And Still We Evolve. Liberal Studies Department, Malaspina University College. Retrieved May 24, 2007.
     *Bowler 2003
     *Zuckerkandl E (2006). "Intelligent design and biological complexity". Gene. 385: 2–18. doi:10.1016/j.gene.2006.03.025. PMID 17011142. {{cite journal}}: Invalid |ref=harv (help)
302. Ross, M.R. (2005). "Who Believes What? Clearing up Confusion over Intelligent Design and Young-Earth Creationism" (PDF). Journal of Geoscience Education. 53 (3): 319. Retrieved April 28, 2008. {{cite journal}}: Invalid |ref=harv (help)
303. Hameed, Salman (December 12, 2008). "Science and Religion: Bracing for Islamic Creationism" (PDF). Science. 322 (5908): 1637–1638. doi:10.1126/science.1163672. PMID 19074331. Retrieved 2009. {{cite journal}}: Check date values in: |accessdate= (help); Invalid |ref=harv (help)
304. Bowler 2003
305. Spergel D. N.; Scott, EC; Okamoto, S (2006). "Science communication. Public acceptance of evolution". Science. 313 (5788): 765–66. doi:10.1126/science.1126746. PMID 16902112. {{cite journal}}: Invalid |ref=harv (help)
306. Spergel, D. N.; Verde, L.; Peiris, H. V.; Komatsu, E.; Nolta, M. R.; Bennett, C. L.; Halpern, M.; Hinshaw, G.; Jarosik, N. (2003). "First-Year Wilkinson Microwave Anisotropy Probe (WMAP) Observations: Determination of Cosmological Parameters". The Astrophysical Journal Supplement Series. 148 (1): 175–94. arXiv:astro-ph/0302209. Bibcode:2003ApJS..148..175S. doi:10.1086/377226. {{cite journal}}: Invalid |ref=harv (help); Unknown parameter |displayauthors= ignored (|display-authors= suggested) (help)
307. Wilde SA, Valley JW, Peck WH, Graham CM (2001). "Evidence from detrital zircons for the existence of continental crust and oceans on the Earth 4.4 Gyr ago". Nature. 409 (6817): 175–78. doi:10.1038/35051550. PMID 11196637. {{cite journal}}: Invalid |ref=harv (help)CS1 maint: multiple names: authors list (link)
308. Branch, Glenn (March 2007). "Understanding Creationism after Kitzmiller". BioScience. 57 (3). American Institute of Biological Sciences: 278–284. doi:10.1641/B570313.

Bibliography

• Altenberg, Lee (1995). "Genome growth and the evolution of the genotype-phenotype map". In Banzhaf, Wolfgang; Eeckman, Frank H. (eds.). Evolution and Biocomputation: Computational Models of Evolution. Lecture Notes in Computer Science. Vol. 899. Berlin; New York: Springer-Verlag Berlin Heidelberg. doi:10.1007/3-540-59046-3_11. ISBN 3-540-59046-3. ISSN 0302-9743. LCCN 95005970. OCLC 32049812. {{cite book}}: Invalid |ref=harv (help)
• Bowler, Peter J. (1989). The Mendelian Revolution: The Emergence of Hereditarian Concepts in Modern Science and Society. Baltimore: Johns Hopkins University Press. ISBN 0-8018-3888-6. LCCN 89030914. OCLC 19322402. {{cite book}}: Invalid |ref=harv (help)
• Bowler, Peter J. (2003). Evolution: The History of an Idea (3rd completely rev. and expanded ed.). Berkeley, CA: University of California Press. ISBN 0-520-23693-9. LCCN 2002007569. OCLC 49824702. {{cite book}}: Invalid |ref=harv (help)
• Burkhardt, Frederick; Smith, Sydney, eds. (1991). The Correspondence of Charles Darwin. The Correspondence of Charles Darwin. Vol. 7: 1858–1859. Cambridge: Cambridge University Press. ISBN 0-521-38564-4. LCCN 84045347. OCLC 185662993. {{cite book}}: Invalid |ref=harv (help)
• Carroll, Sean B.; Grenier, Jennifer K.; Weatherbee, Scott D. (2005). From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design (2nd ed.). Malden, MA: Blackwell Publishing. ISBN 1-4051-1950-0. LCCN 2003027991. OCLC 53972564. {{cite book}}: Invalid |ref=harv (help)
• Cracraft, Joel; Bybee, Rodger W., eds. (2005). Evolutionary Science and Society: Educating a New Generation (PDF). Colorado Springs, CO: Biological Sciences Curriculum Study. ISBN 1-929614-23-3. OCLC 64228003. Retrieved 2014-12-06. {{cite book}}: Invalid |ref=harv (help) "Revised Proceedings of the BSCS, AIBS Symposium November 2004, Chicago, IL"
• Darwin, Charles (1859). On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life (1st ed.). London: John Murray. LCCN 06017473. OCLC 741260650. {{cite book}}: Invalid |ref=harv (help) The book is available from The Complete Work of Charles Darwin Online. Retrieved 2014-11-21.
• Darwin, Francis, ed. (1909). The foundations of The origin of species, a sketch written in 1842 (PDF). Cambridge: Printed at the University Press. LCCN 61057537. OCLC 1184581. Retrieved 2014-11-27. {{cite book}}: Invalid |ref=harv (help)
• Dawkins, Richard (1990). The Blind Watchmaker. Penguin Science. London: Penguin Books. ISBN 0-14-014481-1. OCLC 60143870. {{cite book}}: Invalid |ref=harv (help)
• Dobzhansky, Theodosius (1968). "On Some Fundamental Concepts of Darwinian Biology". In Dobzhansky, Theodosius; Hecht, Max K.; Steere, William C. (eds.). Evolutionary Biology. Volume 2 (1st ed.). New York: Appleton-Century-Crofts. doi:10.1007/978-1-4684-8094-8_1. OCLC 24875357. {{cite book}}: Invalid |ref=harv (help)
• Dobzhansky, Theodosius (1970). Genetics of the Evolutionary Process. New York: Columbia University Press. ISBN 0-231-02837-7. LCCN 72127363. OCLC 97663. {{cite book}}: Invalid |ref=harv (help)
• Ewens, Warren J. (2004). Mathematical Population Genetics. Interdisciplinary Applied Mathematics. Vol. I. Theoretical Introduction (2nd ed.). New York: Springer-Verlag New York. ISBN 0-387-20191-2. LCCN 2003065728. OCLC 53231891. {{cite book}}: Invalid |ref=harv (help)
• Futuyma, Douglas J. (2004). "The Fruit of the Tree of Life: Insights into Evolution and Ecology". In Cracraft, Joel; Donoghue, Michael J. (eds.). Assembling the Tree of Life. Oxford; New York: Oxford University Press. ISBN 0-19-517234-5. LCCN 2003058012. OCLC 61342697. {{cite book}}: Invalid |ref=harv (help) "Proceedings of a symposium held at the American Museum of Natural History in New York, 2002."
• Futuyma, Douglas J. (2005). Evolution. Sunderland, MA: Sinauer Associates. ISBN 0-87893-187-2. LCCN 2004029808. OCLC 57311264. {{cite book}}: Invalid |ref=harv (help)
• Gould, Stephen Jay (2002). The Structure of Evolutionary Theory. Cambridge, MA: Belknap Press of Harvard University Press. ISBN 0-674-00613-5. LCCN 2001043556. OCLC 47869352. {{cite book}}: Invalid |ref=harv (help)
• Hall, Brian K.; Hallgrímsson, Benedikt (2008). Strickberger's Evolution (4th ed.). Sudbury, MA: Jones and Bartlett Publishers. ISBN 978-0-7637-0066-9. LCCN 2007008981. OCLC 85814089. {{cite book}}: Invalid |ref=harv (help)
• Hennig, Willi (1999) . Phylogenetic Systematics. Translation by D. Dwight Davis and Rainer Zangerl; foreword by Donn E. Rosen, Gareth Nelson, and Colin Patterson (Reissue ed.). Urbana, IL: University of Illinois Press. ISBN 0-252-06814-9. LCCN 78031969. OCLC 722701473. {{cite book}}: Invalid |ref=harv (help)
• Jablonka, Eva; Lamb, Marion J. (2005). Evolution in Four Dimensions: Genetic, Epigenetic, Behavioral, and Symbolic Variation in the History of Life. Illustrations by Anna Zeligowski. Cambridge, MA: MIT Press. ISBN 0-262-10107-6. LCCN 2004058193. OCLC 61896061. {{cite book}}: Invalid |ref=harv (help)
• Kirk, Geoffrey; Raven, John; Schofield, Malcolm (1983). The Presocratic Philosophers: A Critical History with a Selection of Texts (2nd ed.). Cambridge; New York: Cambridge University Press. ISBN 0-521-27455-9. LCCN 82023505. OCLC 9081712. {{cite book}}: Invalid |ref=harv (help)
• Lamarck, Jean-Baptiste (1809). Philosophie Zoologique. Paris: Dentu et L'Auteur. OCLC 2210044. {{cite book}}: Invalid |ref=harv (help) Philosophie zoologique (1809) at the Internet Archive. Retrieved 2014-11-29.
• Magner, Lois N. (2002). A History of the Life Sciences (3rd rev. and expanded ed.). New York: Marcel Dekker. ISBN 0-8247-0824-5. LCCN 2002031313. OCLC 50410202. {{cite book}}: Invalid |ref=harv (help)
• Mason, Stephen F. (1962). A History of the Sciences. Collier Books. Science Library, CS9 (New rev. ed.). New York: Collier Books. LCCN 62003378. OCLC 568032626. {{cite book}}: Invalid |ref=harv (help)
• Maynard Smith, John (1998). "The Units of Selection". In Bock, Gregory R.; Goode, Jamie A. (eds.). The Limits of Reductionism in Biology. Novartis Foundation Symposia. Vol. 213. Chichester, England: John Wiley & Sons. doi:10.1002/9780470515488.ch15. ISBN 0-471-97770-5. ISSN 1935-4657. LCCN 98002779. OCLC 38311600. PMID 9653725. {{cite book}}: Invalid |ref=harv (help) "Papers from the Symposium on the Limits of Reductionism in Biology, held at the Novartis Foundation, London, May 13–15, 1997."
• Mayr, Ernst (1982). The Growth of Biological Thought: Diversity, Evolution, and Inheritance. Translation of John Ray by E. Silk. Cambridge, MA: Belknap Press. ISBN 0-674-36445-7. LCCN 81013204. OCLC 7875904. {{cite book}}: Invalid |ref=harv (help)
• Mayr, Ernst (2002) . What Evolution Is. Science Masters. London: Weidenfeld & Nicolson. ISBN 0-297-60741-3. LCCN 2001036562. OCLC 248107061. {{cite book}}: Invalid |ref=harv (help)
• Moore, Randy; Decker, Mark; Cotner, Sehoya (2010). Chronology of the Evolution-Creationism Controversy. Santa Barbara, CA: Greenwood Press/ABC-CLIO. ISBN 978-0-313-36287-3. LCCN 2009039784. OCLC 422757410. {{cite book}}: Invalid |ref=harv (help)
• Nardon, Paul; Grenier, Anne-Marie (1991). "Serial Endosymbiosis Theory and Weevil Evolution: The Role of Symbiosis". In Margulis, Lynn; Fester, René (eds.). Symbiosis as a Source of Evolutionary Innovation: Speciation and Morphogenesis. Cambridge, MA: MIT Press. ISBN 0-262-13269-9. LCCN 90020439. OCLC 22597587. {{cite book}}: Invalid |ref=harv (help) "Based on a conference held in Bellagio, Italy, June 25-30, 1989"
• National Academy of Sciences; Institute of Medicine (2008). Science, Evolution, and Creationism. Washington, D.C.: National Academy Press. ISBN 978-0-309-10586-6. LCCN 2007015904. OCLC 123539346. Retrieved 2014-11-22.
• Odum, Eugene P. (1971). Fundamentals of Ecology (3rd ed.). Philadelphia, PA: Saunders. ISBN 0-7216-6941-7. LCCN 76081826. OCLC 154846. {{cite book}}: Invalid |ref=harv (help)
• Okasha, Samir (2006). Evolution and the Levels of Selection. Oxford; New York: Oxford University Press. ISBN 0-19-926797-9. LCCN 2006039679. OCLC 70985413. {{cite book}}: Invalid |ref=harv (help)
• Panno, Joseph (2005). The Cell: Evolution of the First Organism. Facts on File science library. New York: Facts on File. ISBN 0-8160-4946-7. LCCN 2003025841. OCLC 53901436. {{cite book}}: Invalid |ref=harv (help)
• Provine, William B. (1971). The Origins of Theoretical Population Genetics. Chicago History of Science and Medicine (2nd ed.). Chicago, IL: University of Chicago Press. ISBN 0-226-68464-4. LCCN 2001027561. OCLC 46660910. {{cite book}}: Invalid |ref=harv (help)
• Provine, William B. (1988). "Progress in Evolution and Meaning in Life". In Nitecki, Matthew H. (ed.). Evolutionary Progress. Chicago, IL: University of Chicago Press. ISBN 0-226-58693-6. LCCN 88020835. OCLC 18380658. {{cite book}}: Invalid |ref=harv (help) "This book is the result of the Spring Systematics Symposium held in May, 1987, at the Field Museum in Chicago"
• Quammen, David (2006). The Reluctant Mr. Darwin: An Intimate Portrait of Charles Darwin and the Making of His Theory of Evolution. Great Discoveries (1st ed.). New York: Atlas Books/W. W. Norton & Company. ISBN 978-0-393-05981-6. LCCN 2006009864. OCLC 65400177. {{cite book}}: Invalid |ref=harv (help)
• Ray, John (1686). Historia Plantarum [History of Plants]. Vol. I. Londini: Typis Mariæ Clark. LCCN agr11000774. OCLC 2126030. {{cite book}}: Invalid |ref=harv (help)
• West-Eberhard, Mary Jane (2003). Developmental Plasticity and Evolution. Oxford; New York: Oxford University Press. ISBN 0-19-512235-6. LCCN 2001055164. OCLC 48398911. {{cite book}}: Invalid |ref=harv (help)
• Wiley, E. O.; Lieberman, Bruce S. (2011). Phylogenetics: Theory and Practice of Phylogenetic Systematics (2nd ed.). Hoboken, NJ: Wiley-Blackwell. doi:10.1002/9781118017883. ISBN 978-0-470-90596-8. LCCN 2010044283. OCLC 741259265. {{cite book}}: Invalid |ref=harv (help)
• Wright, Sewall (1984). Genetic and Biometric Foundations. Evolution and the Genetics of Populations. Vol. 1. Chicago, IL: University of Chicago Press. ISBN 0-226-91038-5. LCCN 67025533. OCLC 246124737. {{cite book}}: Invalid |ref=harv (help)

Further reading

• Online books
• Resources in your library
• Resources in other libraries

Introductory reading

• Barrett, Paul H.; Weinshank, Donald J.; Gottleber, Timothy T., eds. (1981). A Concordance to Darwin's Origin of Species, First Edition. Ithaca, NY: Cornell University Press. ISBN 0-8014-1319-2. LCCN 80066893. OCLC 610057960. {{cite book}}: Invalid |ref=harv (help)
• Carroll, S. (2005). Endless Forms Most Beautiful. New York: W.W. Norton. ISBN 0-393-06016-0.
• Charlesworth, Brian; Charlesworth, Deborah (2003). Evolution: A Very Short Introduction. Very Short Introductions. Oxford; New York: Oxford University Press. ISBN 0-19-280251-8. LCCN 2003272247. OCLC 51668497. {{cite book}}: Invalid |ref=harv (help)
• Coyne, J. (2009). Why evolution is true. Penguin Group. ISBN 978-0-670-02053-9.
• Gould, S.J. (1989). Wonderful Life: The Burgess Shale and the Nature of History. New York: W.W. Norton. ISBN 0-393-30700-X.
• Jones, J.S. (2001). Almost Like a Whale: The Origin of Species Updated. (American title: Darwin's Ghost). New York: Ballantine Books. ISBN 0-345-42277-5.
• Mader, Sylvia S. (2007). Biology. Murray P. Pendarvis (9th ed.). McGraw Hill. ISBN 978-0-07-325839-3.
• Maynard Smith, J. (1993). The Theory of Evolution: Canto Edition. Cambridge University Press. ISBN 0-521-45128-0.
• Pallen, M.J. (2009). The Rough Guide to Evolution. Rough Guides. ISBN 978-1-85828-946-5.

Advanced reading

• Barton, N.H., Briggs, D.E.G., Eisen, J.A., Goldstein, D.B. and Patel, N.H. (2007). Evolution. Cold Spring Harbor Laboratory Press. ISBN 0-87969-684-2.{{cite book}}: CS1 maint: multiple names: authors list (link)
• Coyne, J.A. and Orr, H.A. (2004). Speciation. Sunderland: Sinauer Associates. ISBN 0-87893-089-2.{{cite book}}: CS1 maint: multiple names: authors list (link)
• Bergstrom, C.T. and Lee Alan Dugatkin (2011). Evolution. New York: W.W. Norton. ISBN 0-393-92592-7.
• Gould, Stephen J. (2002). The Structure of Evolutionary Theory. Cambridge, MA: Belknap Press of Harvard University Press. ISBN 0-674-00613-5. LCCN 2001043556. OCLC 47869352. {{cite book}}: Invalid |ref=harv (help)
• Maynard Smith, J. and Szathmáry, E. (1997). The Major Transitions in Evolution. Oxfordshire: Oxford University Press. ISBN 0-19-850294-X.{{cite book}}: CS1 maint: multiple names: authors list (link)
• Mayr, Ernst (2001). What Evolution Is. New York: Basic Books. ISBN 0-465-04426-3. LCCN 2001036562. OCLC 47443814. {{cite book}}: Invalid |ref=harv (help)
• Minelli A. (2009) – Forms of Becoming. 242 pp. Princeton: Princeton University Press
• Olson, Wendy; Hall, Brian Keith (2003). Keywords and concepts in evolutionary developmental biology. Cambridge: Harvard University Press. ISBN 0-674-02240-8.{{cite book}}: CS1 maint: multiple names: authors list (link)

External links

2. Part 2

General information

• Evolution on In Our Time at the BBC
• "Evolution". New Scientist. Retrieved May 30, 2011.
• "Evolution Resources from the National Academies". U.S. National Academy of Sciences. Retrieved May 30, 2011.
• "Understanding Evolution: your one-stop resource for information on Evolution". University of California, Berkeley. Retrieved May 30, 2011.
• "Evolution of Evolution – 150 Years of Darwin's "On the Origin of Species"". National Science Foundation. Retrieved May 30, 2011.

Experiments concerning the process of biological evolution

• Lenski RE. "Experimental Evolution – Michigan State University". Retrieved July 31, 2013.
• Algorithms, games, and evolution, Proceedings of the National Academy of Sciences of the USA

Online lectures

• Carroll SB. "The Making of the Fittest". Retrieved May 30, 2011.
• Stearns SC. "Principles of Evolution, Ecology and Behavior". Retrieved August 30, 2011.

• Biology theories
• Evolutionary biology
• Biological evolution
• Evolution