Article snapshot taken from Wikipedia with creative commons attribution-sharealike license.
Give it a read and then ask your questions in the chat.
We can research this topic together.
It was discovered by ] and is being co-developed with ]. A main competitor in the race to worldwide health authority approval is ] in development by Amgen.{{cn}}
It was discovered by ] and is being co-developed with ]. A main competitor in the race to worldwide health authority approval is ] in development by Amgen.{{cn}}
In July 2015, the FDA approved alirocumab to lower ] for people who have ] and people with ] who require additional lowering of LDL cholesterol when diet and ] treatment have not worked.<ref name=FDA2014>FDA. July 24, 2015 </ref> This was the first approval of a ] inhibitor.<ref name=FDA2014/> Its cost is around $15,000 US per year, including for those patients with insurance and prescription assistance.<ref>http://www.msn.com/en-us/news/us/fda-approves-new-cholesterol-drug-at-dollar14600-a-year/ar-AAdsOdi</ref>
In July 2015, the FDA approved alirocumab to lower ] for people who have ] and people with ] who require additional lowering of LDL cholesterol when diet and ] treatment have not worked.<ref name=FDA2014>FDA. July 24, 2015 </ref> This was the first approval of a ] inhibitor.<ref name=FDA2014/>
==Research==
==Research==
Revision as of 20:13, 25 July 2015
This article or section is in a state of significant expansion or restructuring. You are welcome to assist in its construction by editing it as well. If this article or section has not been edited in several days, please remove this template. If you are the editor who added this template and you are actively editing, please be sure to replace this template with {{in use}} during the active editing session. Click on the link for template parameters to use.
This article was last edited by Jytdog (talk | contribs) 9 years ago. (Update timer)
Alirocumab (trade name Praluent) is a human monoclonal antibodyPCSK9 inhibitor biopharmaceutical drug approved by the FDA in July 2015 as a second line treatment of hypercholesterolemia for people whose cholesterol is not controlled by diet and statin treatment. It is also known as REGN727 and SAR236553.
History
It was discovered by Regeneron Pharmaceuticals and is being co-developed with Sanofi. A main competitor in the race to worldwide health authority approval is evolocumab in development by Amgen.
In July 2015, the FDA approved alirocumab to lower LDL cholesterol for people who have hereditary high cholesterol and people with atherosclerosis who require additional lowering of LDL cholesterol when diet and statin treatment have not worked. This was the first approval of a PCSK9 inhibitor.
Research
A phase 3 trial of statin intolerant patients called ODYSSEY ran for 65 weeks. Results were presented at the 2014 European Society of Cardiology meeting.
A 78-week study of alirocumab in 2341 people taking statins who were at high risk for cardiovascular events and had high LDL cholesterol levels was published in April 2015.
Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 24316621, please use {{cite journal}} with |pmid=24316621 instead.
"Efficacy and safety of alirocumab, a monoclonal antibody to PCSK9, in statin-intolerant patients: Design and rationale of ODYSSEY ALTERNATIVE, a randomized phase 3 trial". Journal of Clinical Lipidology. 8: 554–61. Nov–Dec 2014. doi:10.1016/j.jacl.2014.09.007. PMID25499937.
