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Circadian rhythm sleep disorder
Specialty	Neurology

Circadian rhythm sleep disorders are a family of sleep disorders affecting, among other things, the timing of sleep. People with circadian rhythm sleep disorders are unable to sleep and wake at the times required for normal work, school, and social needs. They are generally able to get enough sleep if allowed to sleep and wake at the times dictated by their body clocks. Unless they have another sleep disorder, their sleep is of normal quality.

Humans, like most animals and plants, have biological rhythms, known as circadian rhythms, which are controlled by a biological clock and work on a daily time scale. These affect body temperature, alertness, appetite, hormone secretion etc. as well as sleep timing. Due to the circadian clock, sleepiness does not continuously increase as time passes. A person's desire and ability to fall asleep is influenced by both the length of time since the person woke from an adequate sleep (homeostasis), and by internal circadian rhythms. Thus, the body is ready for sleep and for wakefulness at different times of the day.

Types of circadian rhythm sleep disorders

The circadian rhythm sleep disorders are:

Extrinsic type

• Jet lag, which affects people who travel across several time zones.
• Shift work sleep disorder, which affects people who work nights or rotating shifts.

Intrinsic type

• Delayed sleep phase syndrome (DSPS), which causes a much later than normal timing of sleep onset and offset and a period of peak alertness in the middle of the night.
• Advanced sleep phase syndrome (ASPS), which causes difficulty staying awake in the evening and staying asleep in the morning.
• Non-24-hour sleep-wake syndrome (Non-24), which causes the affected individual's sleep to occur later and later each day, with the period of peak alertness also continuously moving around the clock from day to day.
• Irregular sleep-wake pattern, which presents as sleeping at very irregular times, and usually more than once per day (waking frequently during the night and taking naps during the day) but with total time asleep typical for the person's age.

Normal circadian rhythms

Among people with healthy circadian clocks, there is a continuum of chronotypes from "larks" or "morning people" who prefer to sleep and wake early, to "owls" who prefer to sleep and wake at late times. Whether they are larks or owls, people with normal circadian systems:

• can wake in time for what they need to do in the morning, and fall asleep at night in time to get enough sleep before having to get up.
• can sleep and wake up at the same time every day, if they want to.
• will, after starting a new routine which requires they get up earlier than usual, start to fall asleep at night earlier within a few days. For example, someone who is used to sleeping at 1 am and waking up at 9 a.m. begins a new job on a Monday, and must get up at 6 a.m. to get ready for work. By the following Friday, the person has begun to fall asleep at around 10 p.m., and can wake up at 6 a.m. feeling well-rested. This adaptation to earlier sleep/wake times is known as "advancing the sleep phase." Healthy people can advance their sleep phase by about one hour each day.

Researchers have placed volunteers in caves or special apartments for several weeks without clocks or other time cues. Without time cues, the volunteers tended to go to bed an hour later and to get up about an hour later each day. These experiments appeared to demonstrate that the "free-running" circadian rhythm in humans was about 25 hours long. However, these volunteers were allowed to control artificial lighting and the light in the evening caused a phase delay. More recent research shows that adults of all ages free-run at an average of 24 hours and 11 minutes. To maintain a 24 hour day/night cycle, the biological clock needs regular environmental time cues, e.g. sunrise, sunset, and daily routine. Time cues keep the normal human circadian clock aligned with the rest of the world.

Circadian rhythm abnormalities

Non-24-hour sleep-wake syndrome and other persistent circadian rhythm sleep disorders are believed to be caused by an inadequate ability to reset the sleep/wake cycle in response to environmental time cues. These individuals' circadian clocks might have an unusually long cycle, and/or might not be sensitive enough to time cues. People with DSPS, more common than Non-24, do entrain to nature's 24 hours, but are unable to sleep and awaken at socially preferred times, sleeping instead, for example, from 4 a.m. to noon. According to doctors Cataletto and Hertz at WebMD, "Altered or disrupted sensitivity to zeitgebers is probably the most common cause of circadian rhythm disorder."

As of October 1, 2005, the diagnostic codes for circadian rhythm sleep disorders were changed from the 307-group to the 327-group in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR). The DSM updated to agree with the International Classification of Diseases (ICD-9). The new codes reflect the moving of these disorders from the Mental Disorders section to the Neurological section in the ICD.

See also

• Chronobiology
• Chronotype
• Light therapy
• Melatonin
• Phase response curve
• Sleep diary
• Sleep medicine
• Zeitgeber, any external cue for time-keeping system of organisms such as light

References

1. National Institutes of Health. "Sleep - Information about Sleep". Retrieved 2007-01-28.
2. Cataletto, Mary E. (Updated 2005-09-07). "Sleeplessness and Circadian Rhythm Disorder" (Free registration required). eMedicine from WebMD. Retrieved 2008-07-20. {{cite web}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
3. First, Michael B. (2005). "New Diagnostic Codes for Sleep Disorders". American Psychiatric Association. Retrieved 2008-08-08.

External links

• Circadian Rhythm Sleep Disorder on Psychnet-UK
• An American Academy of Sleep Medicine Review: Circadian Rhythm Sleep Disorders: Part I, Basic Principles, Shift Work and Jet Lag Disorders. PDF, 24 pages. November 2007.
• An American Academy of Sleep Medicine Review: Circadian Rhythm Sleep Disorders: Part II, Advanced Sleep Phase Disorder, Delayed Sleep Phase Disorder, Free-Running Disorder, and Irregular Sleep-Wake Rhythm. PDF, 18 pages. November 2007.

• Sleep disorders
• Circadian rhythms
• Clinical neurophysiology
• Sleep physiology