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Tetracyclic antidepressants (TeCAs) are a class of drugs used primarily as antidepressants, which were first introduced in the 1970s. They are named after their chemical structure, which contains four rings of atoms, and are closely related to the tricyclic antidepressants (TCAs), which contain three rings of atoms.

List of TeCAs

The TeCAs include the following agents:

• Pharmaceutical Drugs
  • Amoxapine (Asendin)
  • Loxapine (Loxapac, Loxitane)
  • Maprotiline (Deprilept, Ludiomil, Psymion)
  • Mianserin (Bolvidon, Norval, Tolvon)
  • Mirtazapine (Remeron, Avanza, Zispin)
  • Setiptiline (Tecipul)
• Research Chemicals
  • Oxaprotiline

Pharmacology

Binding Profiles

A number of TeCAs have been compared below:

They function as antagonists at all sites listed.

The values above are expressed as equilibrium dissociation constants. It should be noted that lower values correspond to higher binding at the site, or in other words, less is more. SERT, NET, and DAT correspond to the abilities of the compounds to inhibit the reuptake of serotonin, norepinephrine, and dopamine, respectively. The other values correspond to their affinity for various receptors.

See also

• Tricyclic antidepressant (TCA)

References

1. Tatsumi M, Groshan K, Blakely RD, Richelson E. (1997). "Pharmacological profile of antidepressants and related compounds at human monoamine transporters". Eur J Pharmacol. 340 (2–3): 249–258. doi:10.1016/S0014-2999(97)01393-9. PMID 9537821.{{cite journal}}: CS1 maint: multiple names: authors list (link)
2. Owens MJ, Morgan WN, Plott SJ, Nemeroff CB. (1997). "Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites". J Pharmacol Exp Ther. 283 (3): 1305–1322. PMID 9400006.{{cite journal}}: CS1 maint: multiple names: authors list (link)
3. Cusack B, Nelson A, Richelson E. (1994). "Binding of antidepressants to human brain receptors: focus on newer generation compounds". Psychopharmacology (Berl). 114 (4): 559–565. doi:10.1007/BF02244985. PMID 7855217.{{cite journal}}: CS1 maint: multiple names: authors list (link)
4. Alan F. Schatzberg, Charles B. (2006). Essentials of clinical psychopharmacology. American Psychiatric Pub. p. 7. ISBN 1585622435, 9781585622436. {{cite book}}: Check |isbn= value: invalid character (help)
5. http://www.psychotropical.com/Mirt_medioc_science.shtml

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