Revision as of 13:31, 5 December 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{chembox}} taken from revid 463645472 of page Polyaminopropyl_biguanide for the Chem/Drugbox validation project (updated: 'CASNo'). |
Latest revision as of 15:41, 24 May 2024 edit Dominik-jan (talk | contribs)338 editsNo edit summary |
Line 1: |
Line 1: |
|
|
{{About|polymer containing propyl linker between guanidine groups|PHMB the antimicrobial polymer incorectly named Polyaminopropyl biguanide|Polyhexanide}} |
|
{{ambox | text = This page contains a copy of the infobox ({{tl|chembox}}) taken from revid of page ] with values updated to verified values.}} |
|
|
|
|
|
{{Chembox |
|
{{Chembox |
|
| Verifiedfields = changed |
|
| Verifiedfields = changed |
|
|
| Watchedfields = changed |
|
| verifiedrevid = 458447351 |
|
| verifiedrevid = 464209381 |
|
| ImageFile = Polyaminopropyl biguanide.svg |
|
| ImageFile = Polyaminopropyl biguanide.svg |
|
| ImageSize = 200px |
|
| ImageAlt = |
|
| ImageAlt = |
|
|
| IUPACName = |
|
| IUPACName = |
|
| OtherNames = Polyamine-propyl-biguanidine |
|
| OtherNames = Polyamine-propyl-biguanidine |
|
| Section1 = {{Chembox Identifiers |
|
|Section1={{Chembox Identifiers |
|
| Abbreviations = PAPB |
|
| Abbreviations = PAPB |
|
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
|
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
|
| ChemSpiderID = NA |
|
| ChemSpiderID = none |
|
| CASNo = <!-- blanked - oldvalue: 133029-32-0 --> |
|
| CASNo = 133029-32-0 |
|
| CASNo_Ref = {{cascite|changed|??}} |
|
| CASNo_Ref = {{cascite|correct|CAS}} |
|
|
| UNII_Ref = {{fdacite|correct|FDA}} |
⚫ |
| PubChem = |
|
|
| SMILES = }} |
|
| UNII = DT9D8Z79ET |
|
⚫ |
| PubChem = |
⚫ |
| Section2 = {{Chembox Properties |
|
|
|
| SMILES = }} |
⚫ |
| Formula = (C<sub>5</sub>H<sub>14</sub>N<sub>6</sub>)<sub>n</sub> |
|
|
⚫ |
|Section2={{Chembox Properties |
|
| MolarMass = |
|
|
⚫ |
| Formula = (C<sub>5</sub>H<sub>11</sub>N<sub>5</sub>)<sub>n</sub> |
|
| Appearance = |
|
|
| Density = |
|
| MolarMass = |
|
| MeltingPt = |
|
| Appearance = |
|
| BoilingPt = |
|
| Density = |
|
| Solubility = }} |
|
| MeltingPt = |
|
|
| BoilingPt = |
⚫ |
| Section3 = {{Chembox Hazards |
|
|
| MainHazards = |
|
| Solubility = }} |
|
⚫ |
|Section3={{Chembox Hazards |
⚫ |
| FlashPt = |
|
|
| Autoignition = }} |
|
| MainHazards = |
|
⚫ |
| FlashPt = |
|
|
| AutoignitionPt = }} |
|
}} |
|
}} |
|
|
|
|
|
'''Polyaminopropyl biguanide''' ('''PAPB''') is a polymer containing biguanide group connected with a three methylene (propyl) linker. The polymer is a propyl analogue of ]. The polymer display some antibacterial activity however much lower than PHMB. <ref>Rembe, J.-D., Fromm-Dornieden, C., Schafer, N., Böhm, J. K., & Stuermer, E. K. (2016). Comparing two polymeric biguanides: chemical distinction, antiseptic efficacy and cytotoxicity of polyaminopropyl biguanide and polyhexamethylene biguanide. *Journal of Medical Microbiology*, 65(8), 867</ref> |
|
|
As of May 2024, PAPB is not approved as a biocidal active substance under EU regulations. <ref> European Chemicals Agency (ECHA). (n.d.). List of approved active substances. Retrieved May 24, 2024, from https://echa.europa.eu/regulations/biocidal-products-regulation/approval-of-active-substances/list-of-approved-active-substances </ref> |
|
|
|
|
|
==Name controversy== |
|
|
In some sources, particularly in lists of cosmetic ingredients (]), the name polyaminopropyl biguanide is wrongly associated with polyhexamethylene biguanide (PHMB) <ref>{{Cite web |title=Safety Assessment of Polyaminopropyl Biguanide as Used in Cosmetics |last1=Cosmetic Ingredient Review Expert Panel |date=May 12, 2014 |url=https://www.cir-safety.org/sites/default/files/polyaminopropyl%20biguanide.pdf |publisher=Cosmetic Ingredient Review (CIR) |access-date=2024-05-07 }}</ref> <ref>{{cite journal |last1=Sukakul |first1=Thanisorn |last2=Dahlin |first2=Jakob |last3=Pontén |first3=Ann |last4=Antelmi |first4=Annarita |last5=Bruze |first5=Magnus |last6=Hamnerius |first6=Nils |last7=Hauksson |first7=Inese |last8=Isaksson |first8=Marléne |last9=Lejding |first9=Tina |last10=Svedman |first10=Cecilia |title=Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide) |journal=Contact Dermatitis |volume=84 |issue=5 |pages=326–331 |year=2021 |doi=10.1111/cod.13728 |pmid=33098110 |pmc=8048451 |url=https://doi.org/10.1111%2Fcod.13728}}</ref> |
|
|
|
|
|
==References== |
|
|
{{reflist}} |
|
|
|
|
|
|
|
|
] |
|
|
] |