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Revision as of 13:31, 5 December 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{chembox}} taken from revid 463645472 of page Polyaminopropyl_biguanide for the Chem/Drugbox validation project (updated: 'CASNo').  Latest revision as of 15:41, 24 May 2024 edit Dominik-jan (talk | contribs)338 editsNo edit summary 
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{{About|polymer containing propyl linker between guanidine groups|PHMB the antimicrobial polymer incorectly named Polyaminopropyl biguanide|Polyhexanide}}
{{ambox | text = This page contains a copy of the infobox ({{tl|chembox}}) taken from revid of page ] with values updated to verified values.}}

{{Chembox {{Chembox
| Verifiedfields = changed | Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 458447351 | verifiedrevid = 464209381
| ImageFile = Polyaminopropyl biguanide.svg | ImageFile = Polyaminopropyl biguanide.svg
| ImageSize = 200px | ImageAlt =
| ImageAlt =
| IUPACName = | IUPACName =
| OtherNames = Polyamine-propyl-biguanidine | OtherNames = Polyamine-propyl-biguanidine
| Section1 = {{Chembox Identifiers |Section1={{Chembox Identifiers
| Abbreviations = PAPB | Abbreviations = PAPB
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = NA | ChemSpiderID = none
| CASNo = <!-- blanked - oldvalue: 133029-32-0 --> | CASNo = 133029-32-0
| CASNo_Ref = {{cascite|changed|??}} | CASNo_Ref = {{cascite|correct|CAS}}
| UNII_Ref = {{fdacite|correct|FDA}}
| PubChem =
| SMILES = }} | UNII = DT9D8Z79ET
| PubChem =
| Section2 = {{Chembox Properties
| SMILES = }}
| Formula = (C<sub>5</sub>H<sub>14</sub>N<sub>6</sub>)<sub>n</sub>
|Section2={{Chembox Properties
| MolarMass =
| Formula = (C<sub>5</sub>H<sub>11</sub>N<sub>5</sub>)<sub>n</sub>
| Appearance =
| Density = | MolarMass =
| MeltingPt = | Appearance =
| BoilingPt = | Density =
| Solubility = }} | MeltingPt =
| BoilingPt =
| Section3 = {{Chembox Hazards
| MainHazards = | Solubility = }}
|Section3={{Chembox Hazards
| FlashPt =
| Autoignition = }} | MainHazards =
| FlashPt =
| AutoignitionPt = }}
}} }}

'''Polyaminopropyl biguanide''' ('''PAPB''') is a polymer containing biguanide group connected with a three methylene (propyl) linker. The polymer is a propyl analogue of ]. The polymer display some antibacterial activity however much lower than PHMB. <ref>Rembe, J.-D., Fromm-Dornieden, C., Schafer, N., Böhm, J. K., & Stuermer, E. K. (2016). Comparing two polymeric biguanides: chemical distinction, antiseptic efficacy and cytotoxicity of polyaminopropyl biguanide and polyhexamethylene biguanide. *Journal of Medical Microbiology*, 65(8), 867</ref>
As of May 2024, PAPB is not approved as a biocidal active substance under EU regulations. <ref> European Chemicals Agency (ECHA). (n.d.). List of approved active substances. Retrieved May 24, 2024, from https://echa.europa.eu/regulations/biocidal-products-regulation/approval-of-active-substances/list-of-approved-active-substances </ref>

==Name controversy==
In some sources, particularly in lists of cosmetic ingredients (]), the name polyaminopropyl biguanide is wrongly associated with polyhexamethylene biguanide (PHMB) <ref>{{Cite web |title=Safety Assessment of Polyaminopropyl Biguanide as Used in Cosmetics |last1=Cosmetic Ingredient Review Expert Panel |date=May 12, 2014 |url=https://www.cir-safety.org/sites/default/files/polyaminopropyl%20biguanide.pdf |publisher=Cosmetic Ingredient Review (CIR) |access-date=2024-05-07 }}</ref> <ref>{{cite journal |last1=Sukakul |first1=Thanisorn |last2=Dahlin |first2=Jakob |last3=Pontén |first3=Ann |last4=Antelmi |first4=Annarita |last5=Bruze |first5=Magnus |last6=Hamnerius |first6=Nils |last7=Hauksson |first7=Inese |last8=Isaksson |first8=Marléne |last9=Lejding |first9=Tina |last10=Svedman |first10=Cecilia |title=Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide) |journal=Contact Dermatitis |volume=84 |issue=5 |pages=326–331 |year=2021 |doi=10.1111/cod.13728 |pmid=33098110 |pmc=8048451 |url=https://doi.org/10.1111%2Fcod.13728}}</ref>

==References==
{{reflist}}


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