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DXP reductoisomerase

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(Redirected from 1-deoxy-D-xylulose-5-phosphate reductoisomerase) InterPro Family
1-deoxy-D-xylulose-5-phosphate reductoisomerase
crystal structure of DXR in complex with the substrate 1-deoxy-D-xylulose 5-phosphate
Identifiers
SymbolDXP_reductoisom
PfamPF02670
Pfam clanCL0063
InterProIPR013512
SCOP21onn / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
DXP reductoisomerase
Identifiers
EC no.1.1.1.267
CAS no.210756-42-6
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DXP reductoisomerase (1-deoxy-D-xylulose 5-phosphate reductoisomerase or DXR) is an enzyme that interconverts 1-deoxy-D-xylulose 5-phosphate (DXP) and 2-C-methyl-D-erythritol 4-phosphate (MEP).

It is classified under EC 1.1.1.267. It is normally abbreviated DXR, but it is sometimes named IspC, as the product of the ispC gene.

DXR is part of the MEP pathway (nonmevalonate pathway) of isoprenoid precursor biosynthesis. DXR is inhibited by fosmidomycin.

This enzyme is required for terpenoid biosynthesis in some organisms, since it is a key enzyme on the MEP pathway for the production of the isoprenoid precursors IPP and DMAPP. In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate reductoisomerase is the first committed enzyme of the MEP pathway for isoprenoid precursor biosynthesis. The enzyme requires Mn, Co or Mg for activity, with Mn being most effective.

References

  1. ^ Takahashi S, Kuzuyama T, Watanabe H, Seto H (August 1998). "A 1-deoxy-D-xylulose-5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in the non-mevalonate pathway for terpenoid biosynthesis". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9879–84. doi:10.1073/pnas.95.17.9879. PMC 21430. PMID 9707569.

External links

This article incorporates text from the public domain Pfam and InterPro: IPR013512 This article incorporates text from the public domain Pfam and InterPro: IPR013644
Metabolism - non-mevalonate pathway enzymes
Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
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