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The 1959 Harelbeke–Antwerp–Harelbeke was the second edition of the E3 Harelbeke cycle race and was held on 17 May 1959. The race started and finished in Harelbeke. The race was won by Norbert Kerckhove.
The race was known as Harelbeke–Antwerp–Harelbeke (French: Harelbeke–Anvers–Harelbeke) for the first twelve editions. In 1970, the race became known as the E3, after the Belgian road which is now known as the E17.