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The 2021 MLS Cup Playoffs (branded as the 2021 Audi MLS Cup Playoffs for sponsorship reasons) was the 26th edition of the MLS Cup Playoffs, the post-season championship of Major League Soccer (MLS), the top soccer league in the United States and Canada. The tournament culminated the 2021 MLS regular season. The tournament began on November 20 and concluded with MLS Cup 2021 on December 11.
The Columbus Crew were the defending MLS Cup champions, but failed to qualify for the playoffs after finishing ninth in the Eastern Conference.
The 2021 MLS Cup Playoffs marked the first time since 2004 that no club from Texas qualified, and the first time ever that no club from California qualified.
The top seven teams in the Eastern and Western Conference qualify for the MLS Cup Playoffs, with the conference champions receiving second round byes. Background colors denote playoff teams, with green also qualifying for the 2022 CONCACAF Champions League.
Note: The higher seeded teams hosted matches, with the MLS Cup host determined by overall points.
First round
The second through fourth-seeded teams in each conference hosted the first-round matches. The team with the best record in each conference got a bye to the Conference Semifinals.