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ACOT12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3B7K, 4MOB, 4MOC
Identifiers
Aliases	ACOT12, CACH-1, Cach, STARD15, THEAL, acyl-CoA thioesterase 12
External IDs	OMIM: 614315; MGI: 1921406; HomoloGene: 12540; GeneCards: ACOT12; OMA:ACOT12 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q14.1 Start 81,329,996 bp End 81,394,179 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 C3 Start 91,889,631 bp End 91,934,267 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle buccal mucosa cell human kidney duodenum gonad Achilles tendon stromal cell of endometrium Hypothalamus muscle tissue Top expressed in right kidney human kidney left lobe of liver proximal tubule jejunum intestinal villus duodenum seminiferous tubule epithelium of small intestine embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carboxylic ester hydrolase activity ATP binding hydrolase activity lipid binding acetyl-CoA hydrolase activity acyl-CoA hydrolase activity fatty-acyl-CoA binding palmitoyl-CoA hydrolase activity long-chain fatty acyl-CoA binding thiolester hydrolase activity Cellular component cytoplasm cytosol Biological process pyruvate metabolic process lipid metabolism acyl-CoA metabolic process acetyl-CoA metabolic process fatty acid metabolic process palmitic acid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 134526 74156 Ensembl ENSG00000172497 ENSMUSG00000021620 UniProt Q8WYK0 Q9DBK0 RefSeq (mRNA) NM_130767 NM_028790 RefSeq (protein) NP_570123 NP_083066 Location (UCSC) Chr 5: 81.33 – 81.39 Mb Chr 13: 91.89 – 91.93 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Acyl-coenzyme A thioesterase 12 or StAR-related lipid transfer protein 15 (STARD15) is an enzyme that in humans is encoded by the ACOT12 gene. The protein contains a StAR-related lipid transfer domain.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000172497 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000021620 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
6. Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.
7. "Entrez Gene: ACOT12 acyl-CoA thioesterase 12".

External links

• Human ACOT12 genome location and ACOT12 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Acetyl-coenzyme A thioesterase

Further reading

• Suematsu N, Isohashi F (2007). "Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase". Acta Biochim. Pol. 53 (3): 553–61. doi:10.18388/abp.2006_3327. PMID 16951743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suematsu N, Okamoto K, Isohashi F (2004). "Simple and unique purification by size-exclusion chromatography for an oligomeric enzyme, rat liver cytosolic acetyl-coenzyme A hydrolase". J. Chromatogr. B. 790 (1–2): 239–44. doi:10.1016/s1570-0232(03)00167-3. PMID 12767336.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suematsu N, Okamoto K, Shibata K, et al. (2001). "Molecular cloning and functional expression of rat liver cytosolic acetyl-CoA hydrolase". Eur. J. Biochem. 268 (9): 2700–9. doi:10.1046/j.1432-1327.2001.02162.x. PMID 11322891.

• Genes on human chromosome 5
• Human proteins