Misplaced Pages

ANAPC11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MT5, 4R2Y, 4UI9, 5A31, 5G04, 5JG6, 5G05
Identifiers
Aliases	ANAPC11, APC11, Apc11p, HSPC214, anaphase promoting complex subunit 11
External IDs	OMIM: 614534; MGI: 1913406; HomoloGene: 41136; GeneCards: ANAPC11; OMA:ANAPC11 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.3 Start 81,890,790 bp End 81,900,991 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 120,489,247 bp End 120,499,024 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis apex of heart Temporal Lobe muscle of thigh Amygdala left ventricle gastrocnemius muscle right auricle substantia nigra Top expressed in atrium yolk sac embryo morula efferent ductule medial ganglionic eminence optic nerve epiblast Ileal epithelium human fetus More reference expression data BioGPS n/a
Gene ontology Molecular function cullin family protein binding ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity ubiquitin-ubiquitin ligase activity Cellular component cytoplasm cytosol anaphase-promoting complex nucleus nucleoplasm nucleolus cullin-RING ubiquitin ligase complex Biological process protein K11-linked ubiquitination cell division protein ubiquitination cell cycle anaphase-promoting complex-dependent catabolic process mitotic cell cycle positive regulation of mitotic metaphase/anaphase transition ubiquitin-dependent protein catabolic process regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51529 66156 Ensembl ENSG00000141552 ENSMUSG00000025135 UniProt Q9NYG5 Q9CPX9 RefSeq (mRNA) NM_016476 NM_001002244 NM_001002245 NM_001002246 NM_001002247 NM_001002248 NM_001002249 NM_001289414 NM_001289415 NM_001289416 NM_001289417 NM_001289418 NM_001289419 NM_001289420 NM_001038230 NM_025389 RefSeq (protein) NP_001002244 NP_001002245 NP_001002246 NP_001002247 NP_001002248 NP_001002249 NP_001276343 NP_001276344 NP_001276345 NP_001276346 NP_001276349 NP_057560 NP_001033319 NP_079665 Location (UCSC) Chr 17: 81.89 – 81.9 Mb Chr 11: 120.49 – 120.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene.

Interactions

ANAPC11 has been shown to interact with ANAPC2 and CDC27.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000141552 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000025135 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Sep 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc Natl Acad Sci U S A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
6. "Entrez Gene: ANAPC11 APC11 anaphase promoting complex subunit 11 homolog (yeast)".
7. Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, Deisenhofer J, Yu H (Dec 2001). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol. Biol. Cell. 12 (12). United States: 3839–51. doi:10.1091/mbc.12.12.3839. ISSN 1059-1524. PMC 60759. PMID 11739784.
8. Ohta T, Michel J J, Schottelius A J, Xiong Y (Apr 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. 3 (4). UNITED STATES: 535–41. doi:10.1016/S1097-2765(00)80482-7. ISSN 1097-2765. PMID 10230407. S2CID 19371828.
9. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17). England: 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947. S2CID 5942532.

External links

• Human ANAPC11 genome location and ANAPC11 gene details page in the UCSC Genome Browser.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chang TS, Jeong W, Lee DY, et al. (2005). "The RING-H2-finger protein APC11 as a target of hydrogen peroxide". Free Radic. Biol. Med. 37 (4): 521–30. doi:10.1016/j.freeradbiomed.2004.05.006. PMID 15256223.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tang Z, Li B, Bharadwaj R, et al. (2002). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol. Biol. Cell. 12 (12): 3839–51. doi:10.1091/mbc.12.12.3839. PMC 60759. PMID 11739784.
• Chan AH, Lee SM, Chim SS, et al. (2001). "Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p". J. Cell. Biochem. 83 (2): 249–58. doi:10.1002/jcb.1217. PMID 11573242. S2CID 45073069.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

• Genes on human chromosome 17