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ANAPC2

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Protein-coding gene in the species Homo sapiens

ANAPC2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4UI9, 4YII, 5A31, 5G05, 5G04

Identifiers
AliasesANAPC2, APC2, anaphase promoting complex subunit 2
External IDsOMIM: 606946; MGI: 2139135; HomoloGene: 8359; GeneCards: ANAPC2; OMA:ANAPC2 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)
Chromosome 9 (human)Genomic location for ANAPC2Genomic location for ANAPC2
Band9q34.3Start137,174,784 bp
End137,188,560 bp
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)
Chromosome 2 (mouse)Genomic location for ANAPC2Genomic location for ANAPC2
Band2|2 A3Start25,162,490 bp
End25,175,927 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • right hemisphere of cerebellum

  • left testis

  • right testis

  • granulocyte

  • left ovary

  • right ovary

  • skin of leg

  • tibial nerve

  • skin of abdomen
Top expressed in
  • internal carotid artery

  • external carotid artery

  • ventricular zone

  • dermis

  • calvaria

  • vestibular membrane of cochlear duct

  • utricle

  • neural tube

  • efferent ductule

  • abdominal wall
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29882

99152

Ensembl

ENSG00000176248

ENSMUSG00000026965

UniProt

Q9UJX6

Q8BZQ7

RefSeq (mRNA)

NM_013366

NM_175300

RefSeq (protein)

NP_037498

NP_780509

Location (UCSC)Chr 9: 137.17 – 137.19 MbChr 2: 25.16 – 25.18 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.

Interactions

ANAPC2 has been shown to interact with ANAPC1 and ANAPC11.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000176248Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000026965Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, Deisenhofer J, Yu H (December 2001). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol Biol Cell. 12 (12): 3839–51. doi:10.1091/mbc.12.12.3839. PMC 60759. PMID 11739784.
  6. ^ "Entrez Gene: ANAPC2 anaphase promoting complex subunit 2".
  7. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947. S2CID 5942532.
  8. Sumara I, Vorlaufer E, Gieffers C, Peters B H, Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.
  9. Ohta T, Michel J J, Schottelius A J, Xiong Y (April 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. ISSN 1097-2765. PMID 10230407. S2CID 19371828.

External links

Further reading


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