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Neutral ceramidase C also known as N-acylsphingosine amidohydrolase 2C or non-lysosomal ceramidase C or ASAH2C is a ceramidase enzyme which in humans is encoded by the ASAH2C gene.
References
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS (April 2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics. 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805. S2CID 20156514.
Further reading
- Choi MS, Anderson MA, Zhang Z, Zimonjic DB, Popescu N, Mukherjee AB (October 2003). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis". Gene. 315: 113–22. doi:10.1016/S0378-1119(03)00721-2. PMID 14557071.
- El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA (July 2000). "Molecular cloning and characterization of a human mitochondrial ceramidase". The Journal of Biological Chemistry. 275 (28): 21508–13. doi:10.1074/jbc.M002522200. PMID 10781606.
- Tani M, Sano T, Ito M, Igarashi Y (November 2005). "Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets". Journal of Lipid Research. 46 (11): 2458–67. doi:10.1194/jlr.M500268-JLR200. PMID 16061940.
- Galadari S, Wu BX, Mao C, Roddy P, El Bawab S, Hannun YA (February 2006). "Identification of a novel amidase motif in neutral ceramidase". The Biochemical Journal. 393 (Pt 3): 687–95. doi:10.1042/BJ20050682. PMC 1360721. PMID 16229686.
- Hwang YH, Tani M, Nakagawa T, Okino N, Ito M (May 2005). "Subcellular localization of human neutral ceramidase expressed in HEK293 cells". Biochemical and Biophysical Research Communications. 331 (1): 37–42. doi:10.1016/j.bbrc.2005.03.134. PMID 15845354.
- Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA (July 2005). "Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha". The Journal of Biological Chemistry. 280 (30): 27879–87. doi:10.1074/jbc.M503002200. PMID 15946935.
| Metabolism, lipid metabolism, glycolipid enzymes | |||||||||
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| Sphingolipid |
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| NCL | |||||||||
| Ceramide synthesis | |||||||||
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