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(Redirected from Alpha-Mannosidase)
Class of enzymes
Cartoon depiction of the protein Streptococcus pyogenes family GH38 α-Mannosidase created using PyMol.
α-Mannosidase (EC3.2.1.24, α-D-mannosidase, p-nitrophenyl-α-mannosidase, α-D-mannopyranosidase, 1,2-α-mannosidase, 1,2-α-D-mannosidase, exo-α-mannosidase) is an enzyme involved in the cleavage of the α form of mannose. Its systematic name is α-D-mannoside mannohydrolase.
Isoenzymes
Humans express the following three α-mannosidase isoenzymes:
It can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development.
Winchester, B. (1984). "Role of α-D-mannosidases in the biosynthesis and catabolism of glycoproteins". Biochem. Soc. Trans. 12 (3): 522–524. doi:10.1042/bst0120522. PMID6428944.
Vlahopoulos S, Gritzapis AD, Perez SA, Cacoullos N, Papamichail M, Baxevanis CN (2009). "Mannose addition by yeast Pichia Pastoris on recombinant HER-2 protein inhibits recognition by the monoclonal antibody herceptin". Vaccine. 27 (34): 4704–8. doi:10.1016/j.vaccine.2009.05.063. PMID19520203.
α-Mannosidase 1, tetramer, Saccharomyces cerevisiae