α-N-Acetylglucosaminidase - Misplaced Pages

The enzyme α-N-acetylglucosaminidase (EC 3.2.1.50, α-acetylglucosaminidase, N-acetyl-α-D-glucosaminidase, N-acetyl-α-glucosaminidase, α-D-2-acetamido-2-deoxyglucosidase) is a protein associated with Sanfilippo syndrome, with systematic name α-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase. It catalyses the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-α-D-glucosaminides, and also UDP-N-acetylglucosamine.

References

Birrane, Gabriel; Dassier, Anne-Laure; Romashko, Alla; Lundberg, Dianna; Holmes, Kevin; Cottle, Thomas; Norton, Angela W.; Zhang, Bohong; Concino, Michael F.; Meiyappan, Muthuraman (2019). "Structural characterization of the α-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B". Journal of Structural Biology. 205 (3): 65–71. doi:10.1016/j.jsb.2019.02.005. PMID 30802506. S2CID 73482664.
von Figura K (November 1977). "Human α-N-acetylglucosaminidase. 1. Purification and properties". European Journal of Biochemistry. 80 (2): 523–533. doi:10.1111/j.1432-1033.1977.tb11908.x. PMID 411658.
von Figura K (November 1977). "Human α-N-acetylglucosaminidase. 2. Activity towards natural substrates and multiple recognition forms". European Journal of Biochemistry. 80 (2): 535–542. doi:10.1111/j.1432-1033.1977.tb11909.x. PMID 923593.
Weissmann B, Rowin G, Marshall J, Friederici D (January 1967). "Mammalian α-acetylglucosaminidase. Enzymic properties, tissue distribution, and intracellular localization". Biochemistry. 6 (1): 207–214. doi:10.1021/bi00853a033. PMID 4291567.
Werries E, Wollek E, Gottschalk A, Buddecke E (October 1969). "Separation of N-acetyl-α-glucosaminidase and N-acetyl-α-galactosaminidase from ox spleen. Cleavage of the O-glycosidic linkage between carbohydrate and polypeptide in ovine and bovine submaxillary glycoprotein by N-acetyl-α-galactosaminidase". European Journal of Biochemistry. 10 (3): 445–449. doi:10.1111/j.1432-1033.1969.tb00709.x. PMID 5348072.

External links

alpha-N-acetyl-D-glucosaminidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

glycosaminoglycan anabolism

Heparan sulfate: EXT1; EXT2

Chondroitin sulfate: PAPSS1; PAPSS2

glycosaminoglycan catabolism

Hunter, Hurler	Iduronate-2-sulfatase Iduronidase
Sanfilippo, Sly	Heparan sulfamidase N-acetyltransferase Alpha-N-acetylglucosaminidase Glucuronidase N-acetylglucosamine-6-sulfatase
Morquio/Maroteaux-Lamy	Arylsulfatase B Galactosamine-6 sulfatase Beta-galactosidase (GLB1)

Hydrolase: sugar hydrolases (EC 3.2)

3.2.1: Glycoside hydrolases

Disaccharidase	Sucrase/Sucrase-isomaltase/Invertase Maltase Trehalase Lactase
Glucosidases	Cellulase Alpha-glucosidase Acid Neutral AB Neutral C Beta-glucosidase cytosolic Debranching enzyme
Other	Amylase Alpha-amylase Chitinase Lysozyme Neuraminidase NEU1 NEU2 NEU3 NEU4 Bacterial neuraminidase Viral neuraminidase Galactosidases Alpha Beta alpha-Mannosidase Glucuronidase Klotho Hyaluronidase Pullulanase Glucosylceramidase lysosomal non-lysosomal Galactosylceramidase Alpha-N-acetylgalactosaminidase NAGA Alpha-N-acetylglucosaminidase Fucosidase Hexosaminidase HEXA HEXB Iduronidase Maltase-glucoamylase Heparanase HPSE2

3.2.2: Hydrolysing
N-Glycosyl compounds

DNA glycosylases: Oxoguanine glycosylase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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