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α-Neoendorphin

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(Redirected from Alpha-neoendorphin)
α-Neoendorphin
Names
Other names Alpha-Neoendorphin
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
IUPHAR/BPS
KEGG
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C60H89N15O13/c1-36(2)30-46(73-56(84)47(32-37-12-4-3-5-13-37)69-51(79)35-67-50(78)34-68-52(80)42(63)31-38-18-22-40(76)23-19-38)55(83)71-44(16-10-28-66-60(64)65)53(81)70-43(14-6-8-26-61)54(82)74-48(33-39-20-24-41(77)25-21-39)58(86)75-29-11-17-49(75)57(85)72-45(59(87)88)15-7-9-27-62/h3-5,12-13,18-25,36,42-49,76-77H,6-11,14-17,26-35,61-63H2,1-2H3,(H,67,78)(H,68,80)(H,69,79)(H,70,81)(H,71,83)(H,72,85)(H,73,84)(H,74,82)(H,87,88)(H4,64,65,66)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1Key: KZTDMJBCZSGHOG-XJIZABAQSA-N
SMILES
  • N(CC1=CC=C(O)C=C1)C(NCC(NCC(N(CC2=CC=CC=C2)C(N(CC(C)C)C(N(CCCNC(N)=N)C(N(CCCCN)C(N(CC3=CC=C(O)C=C3)C(N4CCC4C(N(C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O
Properties
Chemical formula C60H89N15O13
Molar mass 1228.464 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

α-Neoendorphin is an endogenous opioid peptide with a decapeptide structure and the amino acid sequence Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys.

α-Neoendorphin is a neuropeptide. Prodynorphin or Proenkephalin B is its precursor. Researchers and anatomists have not yet studied the distribution of α-neoendorphin in the human in detail. However, some studies have been done which supports the presence of α-neoendorphin immunoreactive fibers throughout the human brainstem. According to a study done by Duque, Ewing, Arturo Mangas, Pablo Salinas, Zaida Díaz-cabiale, José Narváez, and Rafael Coveñas; α-neoendorphin immunoreactive fibers can be found in the caudal part of the solitary nucleus, in the caudal and the gelatinosa parts of the spinal trigeminal nucleus, and only low density was found in the central grey matter of medulla.

See also

References

  1. Kangawa K.; Minamino N.; Chino N (1981). "The complete amino acid sequence of α-neo-endorphin". Biochemical and Biophysical Research Communications. 99 (3): 871–878. doi:10.1016/0006-291X(81)91244-4. PMID 7247946.
  2. Duque, Ewing; Mangas, Arturo; Salinas, Pablo; Díaz-Cabiale, Zaida; Narváez, José Angel; Coveñas, Rafael (2012-02-09). "Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem". Brain Structure and Function. 218 (1): 131–149. doi:10.1007/s00429-012-0388-3. ISSN 1863-2653. PMID 22318412. S2CID 253974523.


Peptides: neuropeptides
Hormonessee hormones
Opioid peptides
Dynorphins
Endomorphins
Endorphins
Enkephalins
Others
Other
neuropeptides
Kinins
Bradykinins
Tachykinins: mammal
amphibian
Neuromedins
Orexins
Other
Opioid receptor modulators
μ-opioid
(MOR)
Agonists
(abridged;
full list)
Antagonists
δ-opioid
(DOR)
Agonists
Antagonists
κ-opioid
(KOR)
Agonists
Antagonists
Nociceptin
(NOP)
Agonists
Antagonists
Others
  • Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)


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