Biotin-dependent malonate decarboxylase

Biotin-dependent malonate decarboxylase (EC 4.1.1.89, malonate decarboxylase (with biotin), malonate decarboxylase) is an enzyme with systematic name malonate carboxy-lyase (biotin-dependent). This enzyme catalyses the following chemical reaction

malonate + H

\rightleftharpoons

acetate + CO₂

Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes.

References

Hilbi H, Dehning I, Schink B, Dimroth P (July 1992). "Malonate decarboxylase of Malonomonas rubra, a novel type of biotin-containing acetyl enzyme". European Journal of Biochemistry. 207 (1): 117–23. doi:10.1111/j.1432-1033.1992.tb17028.x. PMID 1628643.
Hilbi H, Dimroth P (1994). "Purification and characterization of a cytoplasmic enzyme component of the Na+-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase". Archives of Microbiology. 162 (1–2): 48–56. doi:10.1007/bf00264372. PMID 18251085.
Berg M, Hilbi H, Dimroth P (April 1996). "The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2'-(5"-phosphoribosyl)-3'-dephosphocoenzyme A as a prosthetic group". Biochemistry. 35 (15): 4689–96. doi:10.1021/bi952873p. PMID 8664258.
Berg M, Hilbi H, Dimroth P (April 1997). "Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function". European Journal of Biochemistry. 245 (1): 103–15. doi:10.1111/j.1432-1033.1997.00103.x. PMID 9128730.
Micklefield J, Harris KJ, Gröger S, Mocek U, Hilbi H, Dimroth P, Floss HG (1995). "Stereochemical course of malonate decarboxylase in Malonomonas rubra has biotin decarboxylation with retention". J. Am. Chem. Soc. 117 (3): 1153–1154. doi:10.1021/ja00108a042.
Kim YS (September 2002). "Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application". Journal of Biochemistry and Molecular Biology. 35 (5): 443–51. doi:10.5483/bmbrep.2002.35.5.443. PMID 12359084.
Dimroth P, Hilbi H (July 1997). "Enzymic and genetic basis for bacterial growth on malonate". Molecular Microbiology. 25 (1): 3–10. doi:10.1046/j.1365-2958.1997.4611824.x. PMID 11902724.

External links

Biotin-dependent+malonate+decarboxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Carbon–carbon lyases (EC 4.1)
4.1.1: Carboxy-lyases	Acetoacetate decarboxylase Adenosylmethionine decarboxylase Arginine decarboxylase Aromatic L-amino acid decarboxylase Glutamate decarboxylase Histidine decarboxylase Lysine decarboxylase Malonyl-CoA decarboxylase Ornithine decarboxylase Oxaloacetate decarboxylase Phosphoenolpyruvate carboxykinase Phosphoenolpyruvate carboxylase Phosphoribosylaminoimidazole carboxylase Pyrophosphomevalonate decarboxylase Pyruvate decarboxylase RuBisCO Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase Uroporphyrinogen III decarboxylase
4.1.2: Aldehyde-lyases	Fructose-bisphosphate aldolase Aldolase A Aldolase B Aldolase C 2-hydroxyphytanoyl-CoA lyase Threonine aldolase
4.1.3: Oxo-acid-lyases	Isocitrate lyase 3-hydroxy-3-methylglutaryl-CoA lyase
4.1.99: Other	Tryptophanase Photolyase CPD lyase Spore photoproduct lyase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 4.1.1