Biotrauma - Misplaced Pages

Severe inflammatory response in mechanical ventilator patients

Although the term has occasionally been used in other ways, in medical literature biotrauma is usually defined as a severe inflammatory response produced in the lungs of patients who breathe by means of a mechanical ventilator for a long period of time. The term was coined in a 1998 paper by L. N. Tremblay and A. S. Slutsky, titled Ventilator-induced injury: from barotrauma to biotrauma. The message of that paper was that barotrauma caused by pressure differentials is only one of several types of lung damage that a ventilator can produce.

References

Halbertsma FJ, Vaneker M, Scheffer GJ, van der Hoeven JG (2005). "Cytokines and biotrauma in ventilator-induced lung injury: a critical review of the literature". Neth J Med. 63 (10): 382–92. PMID 16301759.
Tremblay LN, Slutsky AS (1998). "Ventilator-induced injury: from barotrauma to biotrauma". Proc Assoc Am Physicians. 110 (6): 482–8. PMID 9824530.

v t e Mechanical ventilation
Fundamentals	Modes of mechanical ventilation Mechanical ventilation in emergencies Nomenclature of mechanical ventilation
Modes	IMV/SIMV CMV ACV CSV PAP BPAP/NIV CPAP APRV MMV PAV ASV HFV List of modes by category
Related illness	ARDS Atelectotrauma Biotrauma Pulmonary barotrauma Pulmonary volutrauma Rheotrauma Ventilator-associated pneumonia Oxygen toxicity Ventilator-associated lung injury
Pressure	P_EEP FiO₂ Δ_P P_IP P_S P_AW P_plat
Volumes	V_T V_E V_f
Other	C_dyn C_static P_AO₂ V_D/V_T OI A-a gradient Mechanical power

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