Misplaced Pages

Bromine (₃₅Br) has two stable isotopes, Br and Br, and 35 known radioisotopes, the most stable of which is Br, with a half-life of 57.036 hours.

Like the radioactive isotopes of iodine, radioisotopes of bromine, collectively radiobromine, can be used to label biomolecules for nuclear medicine; for example, the positron emitters Br and Br can be used for positron emission tomography. Radiobromine has the advantage that organobromides are more stable than analogous organoiodides, and that it is not uptaken by the thyroid like iodine.

List of isotopes

1. Br – Excited nuclear isomer.
2. ( ) – Uncertainty (1σ) is given in concise form in parentheses after the corresponding last digits.
3. # – Atomic mass marked #: value and uncertainty derived not from purely experimental data, but at least partly from trends from the Mass Surface (TMS).
4. Modes of decay:

   IT:	Isomeric transition
   n:	Neutron emission
   p:	Proton emission

5. Bold italics symbol as daughter – Daughter product is nearly stable.
6. Bold symbol as daughter – Daughter product is stable.
7. ( ) spin value – Indicates spin with weak assignment arguments.
8. # – Values marked # are not purely derived from experimental data, but at least partly from trends of neighboring nuclides (TNN).

Bromine-75

Bromine-75 has a half-life of 97 minutes. This isotope undergoes β decay rather than electron capture about 76% of the time, so it was used for diagnosis and positron emission tomography (PET) in the 1980s. However, its decay product, selenium-75, produces secondary radioactivity with a longer half-life of 120.4 days.

Bromine-76

Bromine-76 has a half-life of 16.2 hours. While its decay is more energetic than Br and has lower yield of positrons (about 57% of decays), bromine-76 has been preferred in PET applications since the 1980s because of its longer half-life and easier synthesis, and because its decay product, Se, is not radioactive.

Bromine-77

Bromine-77 is the most stable radioisotope of bromine, with a half-life of 57 hours. Although β decay is possible for this isotope, about 99.3% of decays are by electron capture. Despite its complex emission spectrum, featuring strong gamma-ray emissions at 239, 297, 521, and 579 keV, Br was used in SPECT imaging in the 1970s. However, except for longer-term tracing, this is no longer considered practical due to the difficult collimator requirements and the proximity of the 521 keV line to the 511 keV annihilation radiation related to the β decay. The Auger electrons emitted during decay are nevertheless well-suited for radiotherapy, and Br can possibly be paired with the imaging-suited Br (produced as an impurity in common synthesis routes) for this application.

References

1. ^ Kondev, F. G.; Wang, M.; Huang, W. J.; Naimi, S.; Audi, G. (2021). "The NUBASE2020 evaluation of nuclear properties" (PDF). Chinese Physics C. 45 (3): 030001. doi:10.1088/1674-1137/abddae.
2. "Standard Atomic Weights: Bromine". CIAAW. 2011.
3. Prohaska, Thomas; Irrgeher, Johanna; Benefield, Jacqueline; Böhlke, John K.; Chesson, Lesley A.; Coplen, Tyler B.; Ding, Tiping; Dunn, Philip J. H.; Gröning, Manfred; Holden, Norman E.; Meijer, Harro A. J. (2022-05-04). "Standard atomic weights of the elements 2021 (IUPAC Technical Report)". Pure and Applied Chemistry. doi:10.1515/pac-2019-0603. ISSN 1365-3075.
4. ^ Coenen, Heinz H.; Ermert, Johannes (January 2021). "Expanding PET-applications in life sciences with positron-emitters beyond fluorine-18". Nuclear Medicine and Biology. 92: 241–269. doi:10.1016/j.nucmedbio.2020.07.003. PMID 32900582.
5. ^ Welch, Michael J.; Mcelvany, Karen D. (1 October 1983). "Radionuclides of Bromine for Use in Biomedical Studies". Ract. 34 (1–2): 41–46. doi:10.1524/ract.1983.34.12.41.
6. ^ Lambert, F.; Slegers, G.; Hermanne, α.; Mertens, J. (1 June 1994). "Production and Purification of 77 Br Suitable for Labeling Monoclonal Antibodies Used in Tumor Imaging". Ract. 65 (4): 223–226. doi:10.1524/ract.1994.65.4.223.
7. Wang, Meng; Huang, W.J.; Kondev, F.G.; Audi, G.; Naimi, S. (2021). "The AME 2020 atomic mass evaluation (II). Tables, graphs and references*". Chinese Physics C. 45 (3): 030003. doi:10.1088/1674-1137/abddaf.
8. ^ Wimmer, K.; et al. (2019). "Discovery of Br in secondary reactions of radioactive beams". Physics Letters B. 795: 266–270. arXiv:1906.04067. Bibcode:2019PhLB..795..266W. doi:10.1016/j.physletb.2019.06.014. S2CID 182953245.
9. ^ Kassis, A. I.; Adelstein, S. J.; Haydock, C.; Sastry, K. S. R.; McElvany, K. D.; Welch, M. J. (May 1982). "Lethality of Auger Electrons from the Decay of Bromine-77 in the DNA of Mammalian Cells" (PDF). Radiation Research. 90 (2): 362. Bibcode:1982RadR...90..362K. doi:10.2307/3575714. ISSN 0033-7587. JSTOR 3575714.
10. ^ Jaries, A.; Stryjczyk, M.; Kankainen, A.; Ayoubi, L. Al; Beliuskina, O.; Canete, L.; de Groote, R. P.; Delafosse, C.; Delahaye, P.; Eronen, T.; Flayol, M.; Ge, Z.; Geldhof, S.; Gins, W.; Hukkanen, M.; Imgram, P.; Kahl, D.; Kostensalo, J.; Kujanpää, S.; Kumar, D.; Moore, I. D.; Mougeot, M.; Nesterenko, D. A.; Nikas, S.; Patel, D.; Penttilä, H.; Pitman-Weymouth, D.; Pohjalainen, I.; Raggio, A.; Ramalho, M.; Reponen, M.; Rinta-Antila, S.; de Roubin, A.; Ruotsalainen, J.; Srivastava, P. C.; Suhonen, J.; Vilen, M.; Virtanen, V.; Zadvornaya, A. "Physical Review C - Accepted Paper: Isomeric states of fission fragments explored via Penning trap mass spectrometry at IGISOL". journals.aps.org. arXiv:2403.04710.
11. ^ Shimizu, Y.; Kubo, T.; Sumikama, T.; Fukuda, N.; Takeda, H.; Suzuki, H.; Ahn, D. S.; Inabe, N.; Kusaka, K.; Ohtake, M.; Yanagisawa, Y.; Yoshida, K.; Ichikawa, Y.; Isobe, T.; Otsu, H.; Sato, H.; Sonoda, T.; Murai, D.; Iwasa, N.; Imai, N.; Hirayama, Y.; Jeong, S. C.; Kimura, S.; Miyatake, H.; Mukai, M.; Kim, D. G.; Kim, E.; Yagi, A. (8 April 2024). "Production of new neutron-rich isotopes near the N = 60 isotones Ge 92 and As 93 by in-flight fission of a 345 MeV/nucleon U 238 beam". Physical Review C. 109 (4): 044313. doi:10.1103/PhysRevC.109.044313.
12. Sumikama, T.; et al. (2021). "Observation of new neutron-rich isotopes in the vicinity of Zr110". Physical Review C. 103 (1): 014614. Bibcode:2021PhRvC.103a4614S. doi:10.1103/PhysRevC.103.014614. hdl:10261/260248. S2CID 234019083.
13. ^ Kondev, F. G.; Wang, M.; Huang, W. J.; Naimi, S.; Audi, G. (2021). "The NUBASE2020 evaluation of nuclear properties" (PDF). Chinese Physics C. 45 (3): 030001. doi:10.1088/1674-1137/abddae.
14. Singh, Balraj; Nica, Ninel (May 2012). "Nuclear Data Sheets for A = 77". Nuclear Data Sheets. 113 (5): 1115–1314. Bibcode:2012NDS...113.1115S. doi:10.1016/j.nds.2012.05.001.
15. ^ Amjed, N.; Kaleem, N.; Wajid, A.M.; Naz, A.; Ahmad, I. (January 2024). "Evaluation of the cross section data for the low and medium energy cyclotron production of 77Br radionuclide". Radiation Physics and Chemistry. 214: 111286. doi:10.1016/j.radphyschem.2023.111286.

• Isotope masses from:
  • Audi, Georges; Bersillon, Olivier; Blachot, Jean; Wapstra, Aaldert Hendrik (2003), "The NUBASE evaluation of nuclear and decay properties", Nuclear Physics A, 729: 3–128, Bibcode:2003NuPhA.729....3A, doi:10.1016/j.nuclphysa.2003.11.001
• Isotopic compositions and standard atomic masses from:
  • de Laeter, John Robert; Böhlke, John Karl; De Bièvre, Paul; Hidaka, Hiroshi; Peiser, H. Steffen; Rosman, Kevin J. R.; Taylor, Philip D. P. (2003). "Atomic weights of the elements. Review 2000 (IUPAC Technical Report)". Pure and Applied Chemistry. 75 (6): 683–800. doi:10.1351/pac200375060683.
  • Wieser, Michael E. (2006). "Atomic weights of the elements 2005 (IUPAC Technical Report)". Pure and Applied Chemistry. 78 (11): 2051–2066. doi:10.1351/pac200678112051.
• "News & Notices: Standard Atomic Weights Revised". International Union of Pure and Applied Chemistry. 19 October 2005.
• Half-life, spin, and isomer data selected from the following sources.
  • Audi, Georges; Bersillon, Olivier; Blachot, Jean; Wapstra, Aaldert Hendrik (2003), "The NUBASE evaluation of nuclear and decay properties", Nuclear Physics A, 729: 3–128, Bibcode:2003NuPhA.729....3A, doi:10.1016/j.nuclphysa.2003.11.001
  • National Nuclear Data Center. "NuDat 2.x database". Brookhaven National Laboratory.
  • Holden, Norman E. (2004). "11. Table of the Isotopes". In Lide, David R. (ed.). CRC Handbook of Chemistry and Physics (85th ed.). Boca Raton, Florida: CRC Press. ISBN 978-0-8493-0485-9.

v t e Isotopes of the chemical elements
Group 1 2   3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Period Hydrogen and alkali metals Alkaline earth metals Pnicto­gens Chal­co­gens Halo­gens Noble gases ① Isotopes § ListH1 Isotopes § ListHe2 ② Isotopes § ListLi3 Isotopes § ListBe4 Isotopes § ListB5 Isotopes § ListC6 Isotopes § ListN7 Isotopes § ListO8 Isotopes § ListF9 Isotopes § ListNe10 ③ Isotopes § ListNa11 Isotopes § ListMg12 Isotopes § ListAl13 Isotopes § ListSi14 Isotopes § ListP15 Isotopes § ListS16 Isotopes § ListCl17 Isotopes § ListAr18 ④ Isotopes § ListK19 Isotopes § ListCa20 Isotopes § ListSc21 Isotopes § ListTi22 Isotopes § ListV23 Isotopes § ListCr24 Isotopes § ListMn25 Isotopes § ListFe26 Isotopes § ListCo27 Isotopes § ListNi28 Isotopes § ListCu29 Isotopes § ListZn30 Isotopes § ListGa31 Isotopes § ListGe32 Isotopes § ListAs33 Isotopes § ListSe34 Isotopes § ListBr35 Isotopes § ListKr36 ⑤ Isotopes § ListRb37 Isotopes § ListSr38 Isotopes § ListY39 Isotopes § ListZr40 Isotopes § ListNb41 Isotopes § ListMo42 Isotopes § ListTc43 Isotopes § ListRu44 Isotopes § ListRh45 Isotopes § ListPd46 Isotopes § ListAg47 Isotopes § ListCd48 Isotopes § ListIn49 Isotopes § ListSn50 Isotopes § ListSb51 Isotopes § ListTe52 Isotopes § ListI53 Isotopes § ListXe54 ⑥ Isotopes § ListCs55 Isotopes § ListBa56 Isotopes § ListLu71 Isotopes § ListHf72 Isotopes § ListTa73 Isotopes § ListW74 Isotopes § ListRe75 Isotopes § ListOs76 Isotopes § ListIr77 Isotopes § ListPt78 Isotopes § ListAu79 Isotopes § ListHg80 Isotopes § ListTl81 Isotopes § ListPb82 Isotopes § ListBi83 Isotopes § ListPo84 Isotopes § ListAt85 Isotopes § ListRn86 ⑦ Isotopes § ListFr87 Isotopes § ListRa88 Isotopes § ListLr103 Isotopes § ListRf104 Isotopes § ListDb105 Isotopes § ListSg106 Isotopes § ListBh107 Isotopes § ListHs108 Isotopes § ListMt109 Isotopes § ListDs110 Isotopes § ListRg111 Isotopes § ListCn112 Isotopes § ListNh113 Isotopes § ListFl114 Isotopes § ListMc115 Isotopes § ListLv116 Isotopes § ListTs117 Isotopes § ListOg118 ⑧ Isotopes § ListUue119 Isotopes § ListUbn120 Isotopes § ListLa57 Isotopes § ListCe58 Isotopes § ListPr59 Isotopes § ListNd60 Isotopes § ListPm61 Isotopes § ListSm62 Isotopes § ListEu63 Isotopes § ListGd64 Isotopes § ListTb65 Isotopes § ListDy66 Isotopes § ListHo67 Isotopes § ListEr68 Isotopes § ListTm69 Isotopes § ListYb70   Isotopes § ListAc89 Isotopes § ListTh90 Isotopes § ListPa91 Isotopes § ListU92 Isotopes § ListNp93 Isotopes § ListPu94 Isotopes § ListAm95 Isotopes § ListCm96 Isotopes § ListBk97 Isotopes § ListCf98 Isotopes § ListEs99 Isotopes § ListFm100 Isotopes § ListMd101 Isotopes § ListNo102
Table of nuclides Categories: Isotopes Tables of nuclides Metastable isotopes Isotopes by element

• Isotopes of bromine
• Bromine
• Lists of isotopes by element