Misplaced Pages

Collagenous fibroma

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Benign fibrous tumor Medical condition
Collagenous fibroma
SpecialtyDermatology

Collagenous fibroma, also known as desmoplastic fibroblastoma, is a slow-growing, deep-set, benign fibrous tumor, usually located in the deep subcutis, fascia, aponeurosis, or skeletal muscle of the extremities, limb girdles, or head and neck regions. The World Health Organization in 2020 reclassified desmoplastic fibroblastoma/collagenous fibroma as a specific benign tumor type within the broad category of fibroblastic and myofibroblastic tumors.

Signs and symptoms

Clinically, the lesion is observed as a hard, well-circumscribed, lobulated, round to oval, or fibrous mass that has a sparkling gray-to-white aspect and appears fibrous on the cut surface. Patients with these tumors often appear with a history of a painless, slowly developing mass, often over a reasonably lengthy period of time. These tumors are mostly found in the subcutaneous and skeletal muscle tissues of the extremities. These tumors usually have a diameter of 1 to 20 cm, with a median diameter of 3 cm.

Diagnosis

Collagenous fibroma is characterized histopathologically by long, sweeping fascicles of uniformly spindled cells that range in size from moderately to hypercellular. Long, thick-walled arteries exhibiting perivascular stromal edema are seen. Gardner fibroma, nuchal-type fibroma, and desmoid tumor are examples of differential diagnoses.

The fibroblastic cells have strong vimentin immunohistochemistry. A small number of cells may exhibit positive immunoreactivity for alpha-smooth muscle actin and muscle-specific proteins. The cells resemble fibroblasts or myofibroblasts in terms of ultrastructure.

Treatment

Patients with collagenous fibroma who undergo marginal excision have good surgical results. Video-assisted surgery has been suggested as a substitute for traditional open surgery in the removal of tumors on the chest wall because it minimizes tissue damage and allows for a smaller incision.

See also

References

  1. James, William D.; Berger, Timothy G.; Elston, Dirk M.; Odom, Richard B. (2006). Andrews' diseases of the skin: clinical dermatology (10 ed.). Philadelphia: Saunders Elsevier. ISBN 978-0-7216-2921-6. OCLC 62736861.
  2. Sbaraglia M, Bellan E, Dei Tos AP (April 2021). "The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives". Pathologica. 113 (2): 70–84. doi:10.32074/1591-951X-213. PMC 8167394. PMID 33179614.
  3. Hasegawa, T; Shimoda, T; Hirohashi, S; Hizawa, K; Sano, T (May 1998). "Collagenous fibroma (desmoplastic fibroblastoma): report of four cases and review of the literature". Archives of Pathology & Laboratory Medicine. 122 (5): 455–460. PMID 9593348.
  4. Gong, Li-Hua; Liu, Wei-Feng; Ding, Yi; Geng, Yue-Hang; Sun, Xiao-Qi; Huang, Xiao-Yuan (2018-01-05). "Diagnosis and Differential Diagnosis of Desmoplastic Fibroblastoma by Clinical, Radiological, and Histopathological Analyses". Chinese Medical Journal. 131 (1). Ovid Technologies (Wolters Kluwer Health): 32–36. doi:10.4103/0366-6999.221274. ISSN 0366-6999. PMC 5754955. PMID 29271377.
  5. ^ Harry, Evans (September 1995). "Desmoplastic fibroblastoma. A report of seven cases". The American Journal of Surgical Pathology. 19 (9): 1077–1081. doi:10.1097/00000478-199509000-00012. PMID 7661281. Retrieved 20 April 2024.
  6. ^ Miettinen, Markku; Fetsch, John F (1998). "Collagenous fibroma (desmoplastic fibroblastoma): A clinicopathologic analysis of 63 cases of a distinctive soft tissue lesion with stellate-shaped fibroblasts". Human Pathology. 29 (7). Elsevier BV: 676–682. doi:10.1016/s0046-8177(98)90275-1. ISSN 0046-8177. PMID 9670823.
  7. Bakhshwin, Ahmed; Oaxaca, Gabriel; Armstrong, Susan; Ko, Jennifer; Billings, Steven (2023-09-04). "Superficial desmoplastic fibroblastoma (collagenous fibroma): Clinicopathologic study of 11 cases". Journal of Cutaneous Pathology. 51 (1). Wiley: 70–75. doi:10.1111/cup.14529. ISSN 0303-6987. PMID 37666661.
  8. Osipov, Vladimir; Carrera, Guillermo F. (2009). "Collagenous Fibroma (Desmoplastic Fibroblastoma) with Vertebral Body Erosion". Sarcoma. 2009. Hindawi Limited: 1–3. doi:10.1155/2009/682687. ISSN 1357-714X. PMC 2688648. PMID 19503798.
  9. Bhagalia, Sanjay; Jain, Manish; Pardhe, Nilesh; Sireesha, SundaragiriKrishna (2012). "Collagenous fibroma (desmoplastic fibroblastoma) of the oral cavity". Journal of Oral and Maxillofacial Pathology. 16 (2). Medknow: 277–279. doi:10.4103/0973-029x.99089. ISSN 0973-029X. PMC 3424948. PMID 22923904.
  10. Nakayama, Shizuhide; Nishio, Jun; Aoki, Mikiko; Nabeshima, Kazuki; Yamamoto, Takuaki (2021). "An Update on Clinicopathological, Imaging and Genetic Features of Desmoplastic Fibroblastoma (Collagenous Fibroma)". In Vivo. 35 (1): 69–73. doi:10.21873/invivo.12233. ISSN 0258-851X. PMC 7880796. PMID 33402451.
  11. Giaccone, Agnese; Solli, Piergiorgio; Pardolesi, Alessandro; Brandolini, Jury; Bertolaccini, Luca (2017-05-26). "Video-assisted thoracoscopic surgery en bloc chest wall resection". Journal of Visualized Surgery. 3. AME Publishing Company: 73. doi:10.21037/jovs.2017.04.04. ISSN 2221-2965. PMC 5637527. PMID 29078636.
  12. Ota, Hideki; Ishida, Hirotaka; Matsumoto, Hidekazu; Ishiyama, Tomoharu (2021). "An extremely rare case of desmoplastic fibroblastoma exhibiting rapid growth in the chest wall: a case report". Surgical Case Reports. 7 (1): 86. doi:10.1186/s40792-021-01171-1. ISSN 2198-7793. PMC 8026786. PMID 33829348.

Further reading

External links

ClassificationD
External resources
Connective/soft tissue tumors and sarcomas
Not otherwise specified
Connective tissue neoplasm
Fibromatous
Fibroma/fibrosarcoma
Fibroma/fibromatosis
Histiocytoma/histiocytic sarcoma
Myxomatous
Fibroepithelial
Synovial-like
Lipomatous
Myomatous
General
Smooth muscle
Skeletal muscle
Complex mixed and stromal
Mesothelial
Categories: