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Estradiol butyrylacetate/testosterone ketolaurate/reserpine

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Combination drug Pharmaceutical compound
Estradiol butyrylacetate /
testosterone ketolaurate
Estradiol butyrylacetate (top) and
testosterone ketolaurate (bottom)
Combination of
Estradiol butyrylacetateEstrogen
Testosterone ketolaurateAndrogen; Anabolic steroid
ReserpineAntipsychotic
Clinical data
Trade namesKlimanosid R-Depot
Other namesEBA/TKL; EBA/TCA
Routes of
administration		Intramuscular injection

Estradiol butyrylacetate/testosterone ketolaurate/reserpine (EBA/TKL/R), sold under the brand name Klimanosid R-Depot, is an injectable combination medication of estradiol butyrylacetate (EBA), an estrogen, testosterone ketolaurate (TKL; testosterone caprinoylacetate), an androgen/anabolic steroid, and reserpine, an antipsychotic, which was previously used in menopausal hormone therapy for women, particularly in those with pronounced neurovegetative symptoms. It contains 2 mg EBA, 50 mg TKL, and 0.4 mg reserpine in oil solution in each 1 mL ampoule and is administered by intramuscular injection at regular intervals. The medication was marketed in 1957.

EBA/TKL reportedly has a duration of about 21 days.

Oral tablet products with the same brand names of Klimanosid and Klimanosid R, containing methylestradiol and methyltestosterone, with and without reserpine, were marketed around the same time as Klimanosid-R Depot, and should not be confused with the injectable formulation.

Androgen replacement therapy formulations and dosages used in women
Route Medication Major brand names Form Dosage
Oral Testosterone undecanoate Andriol, Jatenzo Capsule 40–80 mg 1x/1–2 days
Methyltestosterone Metandren, Estratest Tablet 0.5–10 mg/day
Fluoxymesterone Halotestin Tablet 1–2.5 mg 1x/1–2 days
Normethandrone Ginecoside Tablet 5 mg/day
Tibolone Livial Tablet 1.25–2.5 mg/day
Prasterone (DHEA) – Tablet 10–100 mg/day
Sublingual Methyltestosterone Metandren Tablet 0.25 mg/day
Transdermal Testosterone Intrinsa Patch 150–300 μg/day
AndroGel Gel, cream 1–10 mg/day
Vaginal Prasterone (DHEA) Intrarosa Insert 6.5 mg/day
Injection Testosterone propionate Testoviron Oil solution 25 mg 1x/1–2 weeks
Testosterone enanthate Delatestryl, Primodian Depot Oil solution 25–100 mg 1x/4–6 weeks
Testosterone cypionate Depo-Testosterone, Depo-Testadiol Oil solution 25–100 mg 1x/4–6 weeks
Testosterone isobutyrate Femandren M, Folivirin Aqueous suspension 25–50 mg 1x/4–6 weeks
Mixed testosterone esters Climacteron Oil solution 150 mg 1x/4–8 weeks
Omnadren, Sustanon Oil solution 50–100 mg 1x/4–6 weeks
Nandrolone decanoate Deca-Durabolin Oil solution 25–50 mg 1x/6–12 weeks
Prasterone enanthate Gynodian Depot Oil solution 200 mg 1x/4–6 weeks
Implant Testosterone Testopel Pellet 50–100 mg 1x/3–6 months
Notes: Premenopausal women produce about 230 ± 70 μg testosterone per day (6.4 ± 2.0 mg testosterone per 4 weeks), with a range of 130 to 330 μg per day (3.6–9.2 mg per 4 weeks). Footnotes: = Mostly discontinued or unavailable. = Over-the-counter. Sources: See template.

See also

References

  1. ^ "Neue Spezialitäten". Klinische Wochenschrift. 35 (13): 692. 1957. doi:10.1007/BF01481278. ISSN 0023-2173. S2CID 40387087. Klimanosid "R"-Depot enthält je Ampulle: Testosteron als Caprinoytacetat 50,0 mg, Oestradiol als Butyrylacetat 2,0 mg und Reserpin "Boehringer" 0,4 mg (Klimakterische und präklimaterische Ausfallserscheinungen einsehließlich ausgeprägter emotioneller Störungen). Hersteller: C.F. Boehringer & Soehne GmbH, Mannheim.
  2. ^ Schirren C (14 March 2013). "Die Sexualhormone". In Kimmig J (ed.). Therapie der Haut- und Geschlechtskrankheiten. Springer-Verlag. pp. 508–. ISBN 978-3-642-94850-3.
  3. Kaiser R (1962). Die hormonale Behandlung von Zyklusstörungen: ein Leitfaden für die Praxis. Thieme. p. 86.
  4. ^ Gehe & Co (1969). Gehes Codex der pharmazeutischen u. Organotherapeutischen Spezialpräparate(einschl. Der Sera, Impfstoffe, Kosmetica, Reinigungs-, Desinfektions- u. Schädlingsbekämpfungsmittel) umfassend deutsche und zahlreiche ausländische Erzeugnisse. Schwarzeck-Verlag G.m.b.H. KlimanosidDepot-Ampullen (f üher Klimanosid-„R"-Depot-Ampullen) Z : 1 Ampulle zu 1 ml zur i.m. Injektion enthält: 50 mg Testosteron (in Form des Caprinoylacetatsä sowie 2 mg Oestradiol (in Form des Butyrylacetats). I: Klimakterische und
  5. Wenner R, Hauser GA (1959). "". Archiv für Gynäkologie. 193 (1): 58–69. doi:10.1007/BF00837146. PMID 13843987. S2CID 42511052.
  6. Knörr K, Lauritzen C, Beller FK (1972). "Empfängnisregelung — Empfängnisverhütung". Lehrbuch der Gynäkologie. Springer. pp. 227–257. doi:10.1007/978-3-662-00942-0_20. ISBN 978-3-540-05593-8.
  7. Ufer J (1 January 1978). Hormontherapie in der Frauenheilkunde: Grundlagen und Praxis [Hormone Therapy in Gynecology: Principles and Practice] (in German) (5th ed.). de Gruyter. p. 276. ISBN 978-3110066647. OCLC 924728827.
  8. Hager HH, Kern W, List PH, Roth HJ (29 July 2013). Hagers Handbuch der Pharmazeutischen Praxis: Für Apotheker, Arzneimittelhersteller, Ärzte und Medizinalbeamte: Wirkstoffgruppen II Chemikalien und Drogen (A-AL). Springer-Verlag. pp. 157, 160, 185. ISBN 978-3-662-25655-8.
  9. Kahr H, Müller HA (1956). "Behandlung der Menstruationsstörungen". Konservative Therapie der Frauenkrankheiten. Springer. pp. 1–85. doi:10.1007/978-3-7091-5694-0_1. ISBN 978-3-7091-5696-4. Klimanosid: Tabl. 0,005 mg Methyloestradiol + 3,0 mg Methyltestosteron.
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