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(Redirected from Filovirus)
Family of viruses in the order Mononegavirales
The familyFiloviridae is a virological taxon that was defined in 1982 and emended in 1991, 1998, 2000, 2005, 2010 and 2011. The family currently includes the six virusgeneraCuevavirus, Dianlovirus, Ebolavirus, Marburgvirus, Striavirus, and Thamnovirus and is included in the orderMononegavirales. The members of the family (i.e. the actual physical entities) are called filoviruses or filovirids. The name Filoviridae is derived from the Latinnounfilum (alluding to the filamentous morphology of filovirions) and the taxonomicsuffix-viridae (which denotes a virus family).
Note
According to the rules for taxon naming established by the International Committee on Taxonomy of Viruses (ICTV), the name Filoviridae is always to be capitalized, italicized, never abbreviated, and to be preceded by the word "family". The names of its members (filoviruses or filovirids) are to be written in lower case, are not italicized, and used without articles.
Life cycle
Replication cycle of filoviruses and vectorsReplication cycle of filoviruses at and inside host cell
The filovirus life cycle begins with virion attachment to specific cell-surface receptors, followed by fusion of the virion envelope with cellular membranes and the concomitant release of the virus nucleocapsid into the cytosol. The viral RNA-dependent RNA polymerase (RdRp, or RNA replicase) partially uncoats the nucleocapsid and transcribes the genes into positive-stranded mRNAs, which are then translated into structural and nonstructural proteins. Filovirus RdRps bind to a single promoter located at the 3' end of the genome. Transcription either terminates after a gene or continues to the next gene downstream. This means that genes close to the 3' end of the genome are transcribed in the greatest abundance, whereas those toward the 5' end are least likely to be transcribed. The gene order is therefore a simple but effective form of transcriptional regulation. The most abundant protein produced is the nucleoprotein, whose concentration in the cell determines when the RdRp switches from gene transcription to genome replication. Replication results in full-length, positive-stranded antigenomes that are in turn transcribed into negative-stranded virus progeny genome copies. Newly synthesized structural proteins and genomes self-assemble and accumulate near the inside of the cell membrane. Virions bud off from the cell, gaining their envelopes from the cellular membrane they bud from. The mature progeny particles then infect other cells to repeat the cycle.
Family inclusion criteria
Schematic representation of the filovirus genome organization.
A virus that fulfills the criteria for being a member of the order Mononegavirales is a member of the family Filoviridae if:
it forms nucleocapsids with a central axial channel (≈10–15 nm in width) surrounded by a dark layer (≈20 nm in width) and an outer helical layer (≈50 nm in width) with a cross striation (periodicity of ≈5 nm)
The mutation rates in these genomes have been estimated to be between 0.46 × 10 and 8.21 × 10 nucleotide substitutions/site/year. The most recent common ancestor of sequenced filovirus variants was estimated to be 1971 (1960–1976) for Ebola virus, 1970 (1948–1987) for Reston virus, and 1969 (1956–1976) for Sudan virus, with the most recent common ancestor among the four species included in the analysis (Ebola virus, Tai Forest virus, Sudan virus, and Reston virus) estimated at 1000–2100 years. The most recent common ancestor of the Marburg and Sudan species appears to have evolved 700 and 850 years before present respectively. Although mutational clocks placed the divergence time of extant filoviruses at ~10,000 years before the present, dating of orthologous endogenous elements (paleoviruses) in the genomes of hamsters and voles indicated that the extant genera of filovirids had a common ancestor at least as old as the Miocene (~16–23 million or so years ago).
Paleoviral elements are known from each of the four main divergent clades of filoviruses. While orthologous elements in mammal genomes support a minimum age for filoviruses of tens of million of years, the existence of filoviruses and their elements in divergent lineages of fishes suggests that the virus family is hundreds of millions of years old. Paleoviruses that appear to be derived from filovirus-like viruses have been identified in the genomes of many small-bodied species including bats, rodents, shrews, tenrecs, tarsiers,marsupials and fishes. Although most filovirus-like elements appear to be pseudogenes, evolutionary and structural analyses suggest that orthologs isolated from several species of the bat genus Myotis and the rodent family Spalacidae have been maintained by selection.
Vaccines
There are presently very limited vaccines for known filovirus. An effective vaccine against EBOV, developed in Canada, was approved for use in 2019 in the US and Europe. Similarly, efforts to develop a vaccine against Marburg virus are under way.
Mutation concerns and pandemic potential
There has been a pressing concern that a very slight genetic mutation to a filovirus such as EBOV could result in a change in transmission system from direct body fluid transmission to airborne transmission, as was seen in Reston virus (another member of genus Ebolavirus) between infected macaques. A similar change in the current circulating strains of EBOV could greatly increase the infection and disease rates caused by EBOV. However, there is no record of any Ebola strain ever having made this transition in humans.
The Department of Homeland Security’s National Biodefense Analysis and Countermeasures Center considers the risk of a mutated Ebola virus strain with aerosol transmission capability emerging in the future as a serious threat to national security and has collaborated with the Centers for Disease Control and Prevention (CDC) to design methods to detect EBOV aerosols.
US Animal and Plant Health Inspection Service (APHIS) and US Centers for Disease Control and Prevention (CDC). "National Select Agent Registry (NSAR)". Retrieved 2011-10-16.
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