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GDA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AQL, 3E0L, 2UZ9
Identifiers
Aliases	GDA, guanine deaminase, CYPIN, GUANASE, NEDASIN, Guanine deaminase, GAH
External IDs	OMIM: 139260; MGI: 95678; HomoloGene: 3171; GeneCards: GDA; OMA:GDA - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q21.13 Start 72,114,595 bp End 72,257,193 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 B|19 14.32 cM Start 21,368,671 bp End 21,450,809 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum jejunal mucosa pancreatic ductal cell endothelial cell Brodmann area 46 Brodmann area 23 middle temporal gyrus entorhinal cortex superior frontal gyrus Parietal Lobe Top expressed in epithelium of small intestine ventromedial nucleus granulocyte subiculum olfactory tubercle anterior amygdaloid area conjunctival fornix nucleus accumbens piriform cortex lateral septal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity metal ion binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds zinc ion binding guanine deaminase activity protein binding Cellular component cytosol intracellular anatomical structure Biological process guanine catabolic process purine nucleotide catabolic process nucleobase-containing compound metabolic process nervous system development guanine metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9615 14544 Ensembl ENSG00000119125 ENSMUSG00000058624 UniProt Q9Y2T3 Q9R111 RefSeq (mRNA) NM_001242505 NM_001242506 NM_001242507 NM_004293 NM_001351571 NM_001351572 NM_001351573 NM_010266 RefSeq (protein) NP_001229434 NP_001229435 NP_001229436 NP_004284 NP_001338500 NP_001338501 NP_001338502 NP_034396 Location (UCSC) Chr 9: 72.11 – 72.26 Mb Chr 19: 21.37 – 21.45 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Guanine deaminase also known as cypin, guanase, guanine aminase, GAH, and guanine aminohydrolase is an aminohydrolase enzyme which converts guanine to xanthine. Cypin is a major cytosolic protein that interacts with PSD-95. It promotes localized microtubule assembly in neuronal dendrites.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000119125 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000058624 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hitchings GH, Falco EA (Oct 1944). "The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase". Proceedings of the National Academy of Sciences of the United States of America. 30 (10): 294–7. Bibcode:1944PNAS...30..294H. doi:10.1073/pnas.30.10.294. PMC 1078714. PMID 16578130.
6. Kalckar HM (1947). "Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism". J. Biol. Chem. 167 (2): 461–75. doi:10.1016/S0021-9258(17)30999-7. PMID 20285041.
7. Rabinowitz JC, Barker HA (Jan 1956). "Purine fermentation by Clostridium cylindrosporum. II. Purine transformations". The Journal of Biological Chemistry. 218 (1): 161–73. doi:10.1016/S0021-9258(18)65881-8. PMID 13278325.
8. Firestein BL, Firestein BL, Brenman JE, Aoki C, Sanchez-Perez AM, El-Husseini AE, Bredt DS (1999). "Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting". Neuron. 24 (3): 659–72. doi:10.1016/S0896-6273(00)81120-4. PMID 10595517.

External links

• Guanine+deaminase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q9Y2T3 (Human Guanine deaminase) at the PDBe-KB.

• Biology

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• Genes on human chromosome 9
• EC 3.5.4
• EC 3.5 stubs