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major histocompatibility complex, class II, DR15
Haplotypes groups	DRA*01:DRB1*1501 - to - DRA*01:DRB1*1505 DRA*01:DRB1*1507
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA
EBI-HLA	DRA*0101
Identifiers	beta 1 *1501 to *1505 *1507
Symbol(s)	HLA-DRB1
EBI-HLA	DRB1*1501
EBI-HLA	DRB1*1502
EBI-HLA	DRB1*1503
EBI-HLA	DRB1*1504
EBI-HLA	DRB1*1505
EBI-HLA	DRB1*1507
Shared data
Locus	chr.6 6p21.31

HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

Serology

Serotypes are unknown for the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. DRB1*1517N is a null.

Alleles

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Disease associations

DR15 is positively associated Goodpasture syndrome, early age onset multiple sclerosis, pernicious anaemia, sarcoidosis, hypocretin deficiency associated narcolepsy and a predisposition for postmenopausal osteoporosis.

DRB1*1501 is positively associated with Goodpasture syndrome, juvenile rheumatoid arthritis, allergic bronchopulmonary aspergillosis, multiple sclerosis, systemic lupus erythematosus, cervical cancer (human papillomavirus infection), Sjögren syndrome associated with systemic lupus erythematosus, and intermediate uveitis.

DRB1*1502 is associated with systemic lupus erythematosus, systemic sclerosis (SSc) & anti-topoisomerase antibodies.

DRB1*1503 is associated with Chaga's cardiomyopathy, allergic bronchopulmonary aspergillosis, multiple sclerosis, cervical cancer (human papillomavirus infection).

Extended linkage

DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)

DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus

Genetic linkage

HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.

References

1. derived from IMGT/HLA
2. Phelps R, Jones V, Turner A, Rees A (2000). "Properties of HLA class II molecules divergently associated with Goodpasture's disease". Int Immunol. 12 (8): 1135–43. doi:10.1093/intimm/12.8.1135. PMID 10917888.
3. Masterman T, Ligers A, Olsson T, Andersson M, Olerup O, Hillert J (2000). "HLA-DR15 is associated with lower age at onset in multiple sclerosis". Annals of Neurology. 48 (2): 211–9. doi:10.1002/1531-8249(200008)48:2<211::AID-ANA11>3.0.CO;2-R. PMID 10939572. S2CID 9624250.
4. Ungar B, Mathews J, Tait B, Cowling D (1981). "HLA-DR patterns in pernicious anaemia". Br Med J (Clin Res Ed). 282 (6266): 768–70. doi:10.1136/bmj.282.6266.768. PMC 1504598. PMID 6783164.
5. Bilir M, Sipahi S, Yilmaz E, et al. (2007). "Analysis of HLA antigens in Turkish sarcoidosis patients". South. Med. J. 100 (4): 356–9. doi:10.1097/SMJ.0b013e31802f3763. PMID 17458393. S2CID 37606199.
6. Hong SC, Lin L, Lo B, et al. (January 2007). "DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans". Hum. Immunol. 68 (1): 59–68. doi:10.1016/j.humimm.2006.10.006. PMID 17207713.
7. Peled N, Amar A, Peled E, Brautbar C, Pillar G (2002). "DRB1*1502-DQB1*0601-DQA1*0103 and DRB1*04-DQB1*0302 in Jewish hypersomnolent patients". Sleep Med. 3 (3): 267–70. doi:10.1016/S1389-9457(01)00155-1. PMID 14592217.
8. Douroudis K, Tarassi K, Athanassiades T, et al. (2007). "HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population". Tissue Antigens. 69 (6): 592–6. doi:10.1111/j.1399-0039.2007.00833.x. PMID 17498269.
9. Robertson J, Wu J, Arends J, Glass W, Southwood S, Sette A, Lou Y (2005). "Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis". Kidney Int. 68 (3): 1061–70. doi:10.1111/j.1523-1755.2005.00498.x. PMID 16105036.
10. Phelps R, Rees A (1999). "The HLA complex in Goodpasture's disease: a model for analyzing susceptibility to autoimmunity". Kidney Int. 56 (5): 1638–53. doi:10.1046/j.1523-1755.1999.00720.x. PMID 10571772.
11. Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". Hum Immunol. 65 (4): 359–65. doi:10.1016/j.humimm.2004.01.016. PMID 15120191.
12. ^ Slavin R, Hutcheson P, Chauhan B, Bellone C (2004). "An overview of allergic bronchopulmonary aspergillosis with some new insights". Allergy Asthma Proc. 25 (6): 395–9. PMID 15709450.
13. ^ Quelvennec E, Bera O, Cabre P, Alizadeh M, Smadja D, Judge F, Edan G, Semana G (2003). "Genetic and functional studies in multiple sclerosis patients from Martinique attest for a specific and direct role of the HLA-DR locus in the syndrome". Tissue Antigens. 61 (2): 166–71. doi:10.1046/j.0001-2815.2002.00008.x. PMID 12694585.
14. Takeuchi F, Nakano K, Nabeta H, Hong G, Kawasugi K, Mori M, Okudaira H, Kuwata S, Tanimoto K (2005). "Genetic contribution of the tumour necrosis factor (TNF) B + 252*2/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients". International Journal of Immunogenetics. 32 (3): 173–8. doi:10.1111/j.1744-313X.2005.00504.x. PMID 15932622. S2CID 10012283.
15. Apple R, Erlich H, Klitz W, Manos M, Becker T, Wheeler C (1994). "HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity". Nat Genet. 6 (2): 157–62. doi:10.1038/ng0294-157. PMID 8162070. S2CID 24141516.
16. Manoussakis M, Georgopoulou C, Zintzaras E, Spyropoulou M, Stavropoulou A, Skopouli F, Moutsopoulos H (2004). "Sjögren's syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjögren's syndrome". Arthritis Rheum. 50 (3): 882–91. doi:10.1002/art.20093. PMID 15022331.
17. Petrushkin, Harry; Thomas, Dhanes; Vaughan, Robert; Kondeatis, Elli; Stanford, Miles R.; Edelsten, Clive; Wallace, Graham R. (2015-04-01). "Possession of the HLA-DRB1*1501 Allele and Visual Outcome in Idiopathic Intermediate Uveitis". JAMA Ophthalmology. 133 (4): 482–483. doi:10.1001/jamaophthalmol.2014.5868. ISSN 2168-6165. PMID 25634309.
18. ^ Sirikong M, Tsuchiya N, Chandanayingyong D, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Siriboonrit U, Tokunaga K (2002). "Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais". Tissue Antigens. 59 (2): 113–7. doi:10.1034/j.1399-0039.2002.590206.x. PMID 12028537.
19. Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody". Arthritis Rheum. 42 (3): 465–74. doi:10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y. PMID 10088769.
20. García Borrás S, Diez C, Cotorruelo C, Pellizon O, Biondi C, Beloscar J, Bottasso O, Racca A (2006). "HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection". Ann Clin Biochem. 43 (Pt 3): 214–6. doi:10.1258/000456306776865205. PMID 16704757. S2CID 41178678.
21. ^ Maciag P, Schlecht N, Souza P, Franco E, Villa L, Petzl-Erler M (2000). "Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian women". Cancer Epidemiol Biomarkers Prev. 9 (11): 1183–91. PMID 11097225.

• HLA-DR haplotypes