Misplaced Pages

HLA-DR3

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.

Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR3
Haplotypes groups DRA*01:DRB1*03:01 DRA*01:DRB1*03:02 DRA*01:DRB1*03:03 DRA*01:DRB1*03:04
Structure (See HLA-DR)
Identifiers alpha *01:01
Symbol(s) HLA-DRA
EBI-HLA DRA*01:01
Identifiers beta 1 *03:01 *03:01 *03:02 *03:03 *03:04
Symbol(s) HLA-DRB1
EBI-HLA DRB1*03:01
EBI-HLA DRB1*03:02
EBI-HLA DRB1*03:03
EBI-HLA DRB1*03:04
EBI-HLA DRB1*03:05 Archived 2007-09-26 at the Wayback Machine
Shared data
Locus chr.6 6p21.31

HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease. Type 1 diabetes mellitus is associated with HLA-DR3 or HLA-DR4. Nearly half the US population has either DR3 or DR4 (only 1–3% have both), yet only a small percentage (about 0.5%) of these individuals will develop type 1 diabetes.

Serology

DR17 and DR3 recognition of some DRB1*03 alleles
DRB1* DR3 DR17 DR18 Sample
allele % % % size (N)
03:01 33 64 0 9698
03:02 24 3 66 317
03:03 40 60 5
03:04 60 20 5
03:07 >50 1

Some DR3 also react with HLA-DR17 and/or HLA-DR18. The DRB1*03:04 primarily reacts with DR3. The serotypes of *03:05, *03:06, *03:08 to *03:31 are unknown.

Disease associations

Further information: HLA A1-B8-DR3-DQ2 § Importance to Medicine

By serotype

HLA-DR3 is associated with early-age onset myasthenia gravis, Hashimoto's thyroiditis (along with DR5), primary sclerosing cholangitis, and opportunistic infections in AIDS, but lowered risk for cancers. It is also associated with membranous glomerulonephritis

By allele

DRB1*03:01 (see HLA-DR17)

DRB1*03:02 (See HLA-DR18)

DRB1*03:04 is associated with Graves disease

By haplotypes

DR3 and/or DQ2 is associated with Moreen's ulceration, "bout onset" multiple sclerosis, Graves' disease and systemic lupus erythematosus

DR3-DQ2 linkage is associated with coeliac disease, dermatitis herpetiformis, Diabetes mellitus type 1. DR3-DQ2 is the serological marker for HLA-DQ2.5cis isoform. Although it cannot identify the alpha ".5" chain of HLA DQ, DQA1*05:01 gene is almost always found within the DR3-DQ2 haplotype Eurasia (however in older studies DQA1*05:05 is commonly confused with DQA1*05:01)

Genetic linkage

DR3 is genetically linked to HLA-DR52, DRB3*02:02 allele, and HLA-DQ2 (DQ2.5).

References

  1. derived from IMGT/HLA
  2. Wiencke K, Karlsen TH, Boberg KM, Thorsby E, Schrumpf E, Lie BA, Spurkland A (2007). "Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes". Tissue Antigens. 69 (2): 161–9. doi:10.1111/j.1399-0039.2006.00738.x. PMID 17257319.
  3. Pollack MS, Gold J, Metroka CE, Safai B, Dupont B (1984). "HLA-A,B,C and DR antigen frequencies in acquired immunodeficiency syndrome (AIDS) patients with opportunistic infections". Hum. Immunol. 11 (2): 99–103. doi:10.1016/0198-8859(84)90048-X. PMID 6333416.
  4. Mann DL, Murray C, O'Donnell M, Blattner WA, Goedert JJ (1990). "HLA antigen frequencies in HIV-1-related Kaposi's sarcoma". J. Acquir. Immune Defic. Syndr. 3 (Suppl 1): S51–5. PMID 2395088.
  5. Weil L (2014). Quick Reference Guide to Medicine and Surgery. Edinburgh: Mosby: Elsevier. p. 287. ISBN 978-0-7234-3553-2.
  6. Heward, Jm, Allahabadia, A, Sheppard, Mc, Barnett, Ah, Franklyn, Ja, Gough, Sc (Jul 1999). "Association of the large multifunctional proteasome (LMP2) gene with Graves' disease is a result of linkage disequilibrium with the HLA haplotype DRB1*0304-DQB1*02-DQA1*0501". Clinical Endocrinology. 51 (1): 115–8. doi:10.1046/j.1365-2265.1999.00755.x. ISSN 0300-0664. PMID 10468973. S2CID 6376169.
  7. Taylor C, Smith S, Morgan C, Stephenson S, Key T, Srinivasan M, Cunningham E, Watson P (2000). "HLA and Mooren's ulceration". Br J Ophthalmol. 84 (1): 72–5. doi:10.1136/bjo.84.1.72. PMC 1723219. PMID 10611103.
  8. Weinshenker B, Santrach P, Bissonet A, McDonnell S, Schaid D, Moore S, Rodriguez M (1998). "Major histocompatibility complex class II alleles and the course and outcome of MS: a population-based study". Neurology. 51 (3): 742–7. doi:10.1212/wnl.51.3.742. PMID 9748020. S2CID 11416838.
  9. Ratanachaiyavong S, Lloyd L, Darke C, McGregor A (1993). "MHC-extended haplotypes in families of patients with Graves' disease". Hum Immunol. 36 (2): 99–111. doi:10.1016/0198-8859(93)90112-E. PMID 8096501.
  10. Tjernström F, Hellmer G, Nived O, Truedsson L, Sturfelt G (1999). "Synergetic effect between interleukin-1 receptor antagonist allele (IL1RN*2) and MHC class II (DR17,DQ2) in determining susceptibility to systemic lupus erythematosus". Lupus. 8 (2): 103–8. doi:10.1191/096120399678847560. PMID 10192503. S2CID 26486050.
  11. Pera C, Delfino L, Longo A, Pistillo MP, Ferrara GB (March 2000). "Novel associations among HLA-DQA1 and -DQB1 alleles, revealed by high-resolution sequence-based typing (SBT)". Tissue Antigens. 55 (3): 275–9. doi:10.1034/j.1399-0039.2000.550313.x. PMID 10777105.
HLA DR
Genetic loci
DRB1 Serotypes
Serotype of DRB3
Serotype of DRB4
Serotype of DRB5
Category: