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Haplogroup IWX (mtDNA)

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Obsolete haplogroup

In human genetics, Haplogroup IWX was a human mitochondrial DNA (mtDNA) haplogroup.

It was thought to cluster haplogroups I, W, and X. Studies suggested haplogroup IWX to be highly protective against AIDS progression. It is now known that Haplogroup I is descendant of Haplogroup N1. It has also been proposed that Haplogroup W be placed as a descendant of Haplogroup N2b.

References

  1. Maruszak A, Canter JA, Styczyńska M, Zekanowski C, Barcikowska M (November 2009). "Mitochondrial haplogroup H and Alzheimer's disease--is there a connection?". Neurobiology of Aging. 30 (11): 1749–55. doi:10.1016/j.neurobiolaging.2008.01.004. PMID 18308428. S2CID 5067976.
  2. The genome of Homo sapiens
  3. Bermisheva M, Tambets K, Villems R, Khusnutdinova E (2002). "[Diversity of mitochondrial DNA haplotypes in ethnic populations of the Volga-Ural region of Russia]" (PDF). Molekuliarnaia Biologiia (in Russian). 36 (6): 990–1001. PMID 12500536. Archived from the original (PDF) on 2023-11-30. Retrieved 2008-12-08.
  4. Simoni L, Calafell F, Pettener D, Bertranpetit J, Barbujani G (January 2000). "Geographic patterns of mtDNA diversity in Europe" (PDF). American Journal of Human Genetics. 66 (1): 262–78. doi:10.1086/302706. PMC 1288355. PMID 10631156. Archived from the original (PDF) on 2011-07-16. Retrieved 2008-12-08.
  5. Hendrickson SL, Hutcheson HB, Ruiz-Pesini E, et al. (November 2008). "Mitochondrial DNA haplogroups influence AIDS progression". AIDS. 22 (18): 2429–39. doi:10.1097/QAD.0b013e32831940bb. PMC 2699618. PMID 19005266.
  6. van Oven M, Kayser M (February 2009). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–94. doi:10.1002/humu.20921. PMID 18853457. S2CID 27566749.

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6  
L1 L2   L3     L4 L5 L6
M N  
CZ D E G Q   O A S R   I W X Y
C Z B F R0   pre-JT   P   U
HV JT K
H V J T
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