Hydroxymandelonitrile lyase

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming). Other names in common use include hydroxynitrile lyase, oxynitrilase, Sorghum hydroxynitrile lyase, and (S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase. This enzyme participates in cyanoamino acid metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GXS.

References

AJ; Shaw, PJ; Nath, CE; Yadav, SP; Stephen, KR; Earl, JW; McLachlan, AJ (2006). "Population pharmacokinetics of liposomal amphotericin B in pediatric patients with malignant diseases". Antimicrob. Agents Chemother. 50 (3): 935–42. doi:10.1128/AAC.50.3.935-942.2006. PMC 1426421. PMID 16495254.
Seely MK, Criddle RS, Conn EE (1966). "The metabolism of aromatic compounds in higher plants. 8. On the requirement of hydroxynitrile lyase for flavin". J. Biol. Chem. 241 (19): 4457–62. doi:10.1016/S0021-9258(18)99742-5. PMID 5922969.

v t e Carbon–carbon lyases (EC 4.1)
4.1.1: Carboxy-lyases	Acetoacetate decarboxylase Adenosylmethionine decarboxylase Arginine decarboxylase Aromatic L-amino acid decarboxylase Glutamate decarboxylase Histidine decarboxylase Lysine decarboxylase Malonyl-CoA decarboxylase Ornithine decarboxylase Oxaloacetate decarboxylase Phosphoenolpyruvate carboxykinase Phosphoenolpyruvate carboxylase Phosphoribosylaminoimidazole carboxylase Pyrophosphomevalonate decarboxylase Pyruvate decarboxylase RuBisCO Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase Uroporphyrinogen III decarboxylase
4.1.2: Aldehyde-lyases	Fructose-bisphosphate aldolase Aldolase A Aldolase B Aldolase C 2-hydroxyphytanoyl-CoA lyase Threonine aldolase
4.1.3: Oxo-acid-lyases	Isocitrate lyase 3-hydroxy-3-methylglutaryl-CoA lyase
4.1.99: Other	Tryptophanase Photolyase CPD lyase Spore photoproduct lyase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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