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Leonard Calabrese is an American rheumatologist, an osteopathic physician, and an internationally recognized HIV/AIDS and hepatitis C researcher at the Cleveland Clinic. Calabrese is the vice chair of the Cleveland Clinic's Department of Rheumatic and Immunologic Diseases and the co-director of the Center for Vasculitis Care and Research, while also serving as director of the Cleveland Clinic's RJ Fasenmyer Center for Clinical Immunology. He is also a medical professor at the Cleveland Clinic Lerner College of Medicine. Over the course of his academic research career, Calabrese has authored more than 300 publications including book chapters and peer-reviewed journal articles.