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Lutetium(III) chloride

Names
IUPAC name Lutetium(III) chloride
Other names Lutetium chloride, lutetium trichloride
Identifiers
CAS Number	10099-66-8
3D model (JSmol)	Interactive image
ChemSpider	23297
ECHA InfoCard	100.030.205
EC Number	233-240-1
PubChem CID	24919
RTECS number	OK8400000
UNII	2VY5D2E2HC
CompTox Dashboard (EPA)	DTXSID2064941
InChI InChI=1S/3ClH.Lu/h3*1H;/q;;;+3/p-3Key: AEDROEGYZIARPU-UHFFFAOYSA-K InChI=1S/3ClH.Lu/h3*1H;/q;;;+3/p-3Key: AEDROEGYZIARPU-DFZHHIFOAO Key: AEDROEGYZIARPU-UHFFFAOYSA-K
SMILES Cl(Cl)Cl
Properties
Chemical formula	LuCl3
Molar mass	281.325 g/mol
Appearance	colorless or white monoclinic crystals
Density	3.98 g/cm
Melting point	925 °C (1,697 °F; 1,198 K)
Boiling point	sublimes above 750°C
Solubility in water	soluble
Structure
Crystal structure	Monoclinic, mS16
Space group	C2/m, No. 12
Pharmacology
License data	EU EMA: by Lutetium (177 Lu) chloride
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	Irritant
GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H315, H319, H335
Precautionary statements	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
NFPA 704 (fire diamond)	2 0 1
Related compounds
Other anions	Lutetium(III) oxide
Other cations	Ytterbium(III) chloride Scandium(III) chloride Yttrium(III) chloride
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). N verify (what is  ?) Infobox references

Lutetium(III) chloride or lutetium trichloride is the chemical compound composed of lutetium and chlorine with the formula LuCl₃. It forms hygroscopic white monoclinic crystals and also a hygroscopic hexahydrate LuCl₃·6H₂O. Anhydrous lutetium(III) chloride has the YCl₃ (AlCl₃) layer structure with octahedral lutetium ions.

Lutetium-177, a radioisotope that can be derived from lutetium(III) chloride, is used in targeted cancer therapies. When lutetium-177 is attached to molecules that specifically target cancer cells, it can deliver localized radiation to destroy those cells while sparing surrounding healthy tissue. This makes lutetium-177-based treatments especially valuable for cancers that are difficult to treat with traditional methods, such as neuroendocrine tumors and prostate cancer. Additionally, lutetium(III) chloride is used in scintillators, materials that emit light when exposed to radiation. These scintillators are crucial in detectors for gamma rays and other high-energy particles, used in both medical diagnostics and in scientific research.

Reactions

Pure lutetium metal can be produced from lutetium(III) chloride by heating it together with elemental calcium:

2 LuCl₃ + 3 Ca → 2 Lu + 3 CaCl₂

See also

• Lutetium (177Lu) chloride

References

1. "Chemistry: Periodic Table: Lutetium: compound data (lutetium (III) chloride)". WebElements. Retrieved 2024-09-06.
2. Perry, Dale L.; Phillips, Sidney L. (1995), Handbook of Inorganic Compounds, CRC Press, p. 232, ISBN 0-8493-8671-3, retrieved 2008-06-27
3. ^ Lide, David R. (1998), Handbook of Chemistry and Physics (87 ed.), Boca Raton, Florida: CRC Press, p. 472, ISBN 0-8493-0594-2, retrieved 2008-06-27
4. "450960 Lutetium(III) chloride anhydrous, powder, 99.99% trace metals basis". Sigma-Aldrich. Retrieved 2008-06-27.
5. "Lutetium chloride". pubchem.ncbi.nlm.nih.gov.
6. "Lutetium(III) chloride hexahydrate 542075". Sigma-Aldrich. Retrieved 2019-07-24.
7. Wells A.F. (1984) Structural Inorganic Chemistry 5th edition Oxford Science Publications ISBN 0-19-855370-6
8. Sgouros, George; Bodei, Lisa; McDevitt, Michael R.; Nedrow, Jessie R. (September 2020). "Radiopharmaceutical therapy in cancer: clinical advances and challenges". Nature Reviews Drug Discovery. 19 (9): 589–608. doi:10.1038/s41573-020-0073-9. ISSN 1474-1784. PMC 7390460.
9. Vyas, Madhusudan (2021-05-01). "Lutetium-177: a flexible radionuclide therapeutic options". Journal of Nuclear Medicine. 62 (supplement 1): 3039–3039. ISSN 0161-5505.
10. Dash, Ashutosh; Pillai, Maroor Raghavan Ambikalmajan; Knapp, Furn F. (2015-06-01). "Production of 177Lu for Targeted Radionuclide Therapy: Available Options". Nuclear Medicine and Molecular Imaging. 49 (2): 85–107. doi:10.1007/s13139-014-0315-z. ISSN 1869-3482. PMC 4463871. PMID 26085854.
11. Vogel, W. V.; van der Marck, S. C.; Versleijen, M. W. J. (2021-07-01). "Challenges and future options for the production of lutetium-177". European Journal of Nuclear Medicine and Molecular Imaging. 48 (8): 2329–2335. doi:10.1007/s00259-021-05392-2. ISSN 1619-7089. PMC 8241800. PMID 33974091.
12. Das, Tapas; Banerjee, Sharmila (2016). "Theranostic Applications of Lutetium-177 in Radionuclide Therapy". Current Radiopharmaceuticals. 9 (1): 94–101. doi:10.2174/1874471008666150313114644. ISSN 1874-4729. PMID 25771364.
13. Patnaik, Pradyot (2004), Handbook of Inorganic Chemicals, Amsterdam: McGraw-Hill Professional, p. 244, ISBN 0-07-049439-8, retrieved 2008-06-27

• Lutetium compounds
• Chlorides
• Lanthanide halides