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Viral matrix protein

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Viral matrix protein (Paramyxoviridae and Pneumoviridae)
Identifiers
SymbolMatrix
PfamPF00661
InterProIPR000982
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Viral matrix proteins are structural proteins linking the viral envelope with the virus core. They play a crucial role in virus assembly, and interact with the RNP complex as well as with the viral membrane. They are found in many enveloped viruses including paramyxoviruses, orthomyxoviruses, herpesviruses, retroviruses, filoviruses and other groups.

An example is the M1 protein of the influenza virus, showing affinity to the glycoproteins inserted in the host cell membrane on one side and affinity for the RNP complex molecules on the other side, which allows formation at the membrane of a complex made of the viral ribonucleoprotein at the inner side indirectly connected to the viral glycoproteins protruding from the membrane. This assembly complex will now bud out of the cell as new mature viruses.

Viral matrix proteins, like many other viral proteins, can exert different functions during the course of the infection. For example, in rhabdoviruses, binding of M proteins to nucleocapsids is accountable for the formation of its “bullet” shaped virions.

In herpesviruses, the viral matrix is usually called viral tegument and contains many proteins involved in viral entry, early gene expression and immune evasion.

References

  1. Battisti AJ, Meng G, Winkler DC, McGinnes LW, Plevka P, Steven AC, Morrison TG, Rossmann MG (August 2012). "Structure and assembly of a paramyxovirus matrix protein". Proceedings of the National Academy of Sciences of the United States of America. 109 (35): 13996–4000. doi:10.1073/pnas.1210275109. PMC 3435216. PMID 22891297.

See also

Viral proteins (early and late)
DNA
linear ds-DNA
(Duplodnaviria,
Varidnaviria)
Herpes simplex
VSPs:
capsid:
VNPs:
Vaccinia
VNPs:
Adenoviridae
VNPs:
circular ds-DNA
(Duplodnaviria,
Varidnaviria?)
Epstein–Barr
VSPs:
VNPs:
ncRNA:
Baculoviridae
VNPs:
other
(Riboviria,
Monodnaviria)
Polyomaviridae
(SV40, MPyV, MCPyV, HaPyV)
(non-enveloped circular ds-DNA)
VSPs:
capsid:
VNPs:
oncoprotein:
Hepatitis B
(circular partially ds-DNA)
VSPs:
  • HBsAg
  • HBcAg
  • VNPs:
    RNA
    ds-RNA
    (Riboviria)
    Rotavirus
    (Duplornaviricota)
    VNPs:
    Rhinov., Polio, Hep A,
    etc. (Pisuviricota)
    VNPs:
    ss-RNA
    positive-sense
    (Riboviria)
    Hepatitis C
    (Kitrinoviricota)
    VSPs:
    VNPs:
    SARS-CoV-2
    (Pisuviricota)
    VSPs:
    VNPs:
    ss-RNA
    negative-sense
    (Negarnaviricota)
    Influenza virus
    VSPs:
    capsid:
    glycoprotein:
    VNPs:
    Parainfluenza
    VSPs:
    glycoprotein:
    Mumps
    VSPs:
    glycoprotein:
    Measles
    VSPs:
    glycoprotein:
    RSV
    VSPs:
    glycoprotein:
    Zaire ebolavirus
    VSPs:
    capsid:
    Indiana vesiculovirus
    VSPs:
    capsid:
    RT
    Structure and genome of HIV
    VSPs:
    VRAPs:
    Multiple
    Fusion protein
    oncoprotein:
  • Gag-onc fusion protein
  • Categories: