| methylarsonate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.20.4.2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a methylarsonate reductase (EC 1.20.4.2) is an enzyme that catalyzes the chemical reaction
- methylarsonate + 2 glutathione methylarsonite + glutathione disulfide + H2O
methylarsonite + glutathione disulfide + H2OThus, the two substrates of this enzyme are methylarsonate and glutathione, whereas its 3 products are methylarsonite, glutathione disulfide, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on phosphorus or arsenic in donor with disulfide as acceptor. The systematic name of this enzyme class is gluthathione:methylarsonate oxidoreductase. This enzyme is also called MMA(V) reductase.
References
- Zakharyan RA, Aposhian HV (1999). "Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase". Chem. Res. Toxicol. 12 (12): 1278–83. doi:10.1021/tx9901231. PMID 10604879.
| Other oxidoreductases (EC 1.15–1.21) | |
|---|---|
| 1.15: Acting on superoxide as acceptor | |
| 1.16: Oxidizing metal ions | |
| 1.17: Acting on CH or CH2 groups | |
| 1.18: Acting on iron–sulfur proteins as donors | |
| 1.19: Acting on reduced flavodoxin as donor | |
| 1.20: Acting on phosphorus or arsenic in donors | |
| 1.21: Acting on X-H and Y-H to form an X-Y bond | |
| Enzymes | |
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| Activity | |
| Regulation | |
| Classification | |
| Kinetics | |
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