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miR156 microRNA precursor
Predicted secondary structure and sequence conservation of mir-156
Identifiers
Symbol	miR156
Rfam	RF00073
miRBase	MI0000178
miRBase family	MIPF0000008
Other data
RNA type	Gene; miRNA
Domain(s)	Eukaryota
GO	GO:0035195 GO:0035068
SO	SO:0001244
PDB structures	PDBe

MicroRNA (miRNA) precursor miR156 is a family of plant non-coding RNA. This microRNA has now been predicted or experimentally confirmed in a range of plant species (MIPF0000008). miR156 functions in the induction of flowering by suppressing the transcripts of SQUAMOSA-PROMOTER BINDING LIKE (SPL) transcription factors gene family. It was suggested that the loading into ARGONAUTE1 and ARGONAUTE5 is required for miR156 functionality in Arabidopsis thaliana. In plants the precursor sequences may be longer, and the carpel factory (caf) enzyme appears to be involved in processing. In this case the mature sequence comes from the 5' arm of the precursor, and both Arabidopsis thaliana and rice genomes contain a number of related miRNA precursors which give rise to almost identical mature sequences. The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. The products are thought to have regulatory roles through complementarity to mRNA.

This miRNA is involved in control of reproductive structures in liverworts.

References

1. Roussin-Léveillée, Charles; Silva-Martins, Guilherme; Moffett, Peter (2020). "ARGONAUTE5 Represses Age-Dependent Induction of Flowering through Physical and Functional Interaction with miR156 in Arabidopsis". Plant Cell Physiology. 61 (5): 957–966. doi:10.1093/pcp/pcaa022. PMID 32105323.
2. Tsuzuki, Masayuki; Futagami, Kazutaka; Shimamura, Masaki; Inoue, Chikako; Kunimoto, Kan; Oogami, Takashi; Tomita, Yuki; Inoue, Keisuke; Kohchi, Takayuki; Yamaoka, Shohei; Araki, Takashi; Hamada, Takahiro; Watanabe, Yuichiro (2019). "An Early Arising Role of the MicroRNA156/529-SPL Module in Reproductive Development Revealed by the Liverwort Marchantia polymorpha". Current Biology. 29 (19): 3307–3314.e5. doi:10.1016/j.cub.2019.07.084. ISSN 0960-9822. PMID 31543452.

Further reading

• Reinhart BJ, Weinstein EG, Rhoades MW, Bartel B, Bartel DP (July 2002). "MicroRNAs in plants". Genes & Development. 16 (13): 1616–26. doi:10.1101/gad.1004402. PMC 186362. PMID 12101121.
• Ambros V (December 2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458. S2CID 14574186.
• Zhang B, Pan X (July 2009). "Expression of microRNAs in cotton". Molecular Biotechnology. 42 (3): 269–74. doi:10.1007/s12033-009-9163-y. PMID 19288227. S2CID 207376300.
• Yu S, Galvão VC, Zhang YC, Horrer D, Zhang TQ, Hao YH, Feng YQ, Wang S, Schmid M, Wang JW (August 2012). "Gibberellin regulates the Arabidopsis floral transition through miR156-targeted SQUAMOSA promoter binding-like transcription factors". The Plant Cell. 24 (8): 3320–32. doi:10.1105/tpc.112.101014. PMC 3462634. PMID 22942378.

External links

• Page for mir-156 microRNA precursor at Rfam
• MIPF0000008

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