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In enzymology, a N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase (EC 2.4.1.225) is an enzyme that catalyzes the chemical reaction

UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl- proteoglycan ${\displaystyle \rightleftharpoons }$ UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan

The 3 substrates of this enzyme are UDP-alpha-D-glucuronate, ], and proteoglycan, whereas its 3 products are UDP, ], and beta-D-glucuronosyl-proteoglycan.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D- glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase. Other names in common use include N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase, and heparan glucuronyltransferase II. This enzyme participates in heparan sulfate biosynthesis and glycan structures - biosynthesis 1.

References

• K, Lindahl U, Kusche-Gullberg M (2000). "The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis". EMBO Reports. 1 (3): 282–6. doi:10.1093/embo-reports/kvd045. PMC 1083719. PMID 11256613.
• Lind T, Tufaro F, McCormick C, Lindahl U, Lidholt K (1998). "The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate". J. Biol. Chem. 273 (41): 26265–8. doi:10.1074/jbc.273.41.26265. PMID 9756849.

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