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Neticonazole

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Chemical compound Pharmaceutical compound
Neticonazole
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • 1-{(E)-2-(Methylthio)-1-vinyl}-1H-imidazole
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H22N2OS
Molar mass302.44 g·mol
3D model (JSmol)
SMILES
  • CCCCCOc1ccccc1/C(=C\SC)/n2ccnc2
InChI
  • InChI=1S/C17H22N2OS/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3/b16-13+
  • Key:VWOIKFDZQQLJBJ-DTQAZKPQSA-N
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Neticonazole (INN) is an imidazole antifungal for the treatment of fungal skin infections.

Neticonazole is only approved for use in Japan. It is sold as a topical ointment under the tradename Atolant.

References

  1. Nimura K, Niwano Y, Ishiduka S, Fukumoto R (August 2001). "Comparison of in vitro antifungal activities of topical antimycotics launched in 1990s in Japan". Int. J. Antimicrob. Agents. 18 (2): 173–8. doi:10.1016/S0924-8579(01)00365-X. PMID 11516941.
  2. Tsuboi R, Matsumoto T, Ogawa H (May 1996). "Hyperkeratotic chronic tinea pedis treated with neticonazole cream. Neticonazole Study Group". Int. J. Dermatol. 35 (5): 371–3. doi:10.1111/j.1365-4362.1996.tb03644.x. PMID 8734665. S2CID 34516725.
Antifungals (D01 and J02)
Wall/
membrane
Ergosterol
inhibitors
Azoles (lanosterol 14α-
demethylase inhibitors)
Imidazoles
  • Systemic: ketoconazole
Triazoles
Thiazoles
Polyene antimycotics
(ergosterol binding)
Squalene monooxygenase
inhibitors
Allylamines
Benzylamines
Others
β-glucan synthase
inhibitors
Intracellular
Pyrimidine analogues/
thymidylate synthase inhibitors
Mitotic inhibitors
Aminoacyl tRNA synthetase inhibitors
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