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Route 346 begins near Newville at an intersection with Route 340 (Road to the Isles) and it heads northeast through wooded and hilly terrain for several kilometres to pass through Cobb's Arm, where it has an intersection with a local road leading to Roger's Cove. The highway now curves to the northwest to meet a local road leading to Pike's Arm and Green Cove before entering Toogood Arm and coming to an end at a Cul-de-sac.