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Route 403 begins at an intersection with Route 1 (Trans-Canada Highway) along the banks of Flat Bay Brook. It heads west paralleling the brook to pass through Joyce, where it makes a sharp right turn to the north to enter Flat Bay, where it makes a left turn as it passes through town. The highway now heads southwest along the coastline to pass through Flat Bay West and St. Teresa before coming to a dead end in Journois.