Polydiethylstilbestrol phosphate

Chemical compound "PDSP" redirects here. For the political party in the Philippines, see Partido Demokratiko Sosyalista ng Pilipinas. Pharmaceutical compound

Polydiethylstilbestrol phosphate
Clinical data

Other names	PSP; PDSP; Diethylstilbestrol polymer with phosphoric acid; (E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis(phenol) polymer with phosphoric acid
Routes of administration	Intramuscular injection
Drug class	Estrogen; Nonsteroidal estrogen; Estrogen ester
Identifiers
CAS Number	30852-64-3
Chemical and physical data
Formula	(C₁₈H₁₉O₄P)_n

Polydiethylstilbestrol phosphate (PSP, PDSP) is an estrogen medication which has been used in scientific research and has been studied for use in veterinary medicine as a livestock growth promoter. It is a phosphate ester of diethylstilbestrol (DES) in the form of a polymer and is a polymeric form of fosfestrol (diethylstilbestrol diphosphate); PDSP acts as a long-lasting prodrug of DES. It has similarities to polyestradiol phosphate and polyestriol phosphate.

References

^ Diczfalusy E, Fernö H, Fex B, Högberg B, Kneip P (1959). "High Molecular Weight Enzyme Inhibitors. IV. Polymeric Phosphates of Synthetic Estrogens" (PDF). Acta Chem. Scand. 13 (5): 1011–1018. doi:10.3891/acta.chem.scand.13-1011.
Bengtsson G, Ullberg S, Perklev T (August 1963). "Autoradiographic Distribution Studies after Administration of a Macromolecular Synthetic Oestrogen (14C-Polydiethylstilboestrol Phosphate)". Acta Endocrinol. 43 (4): 571–80. doi:10.1530/acta.0.0430571. PMID 14059878.
Perklev T (November 1964). "Distribution and Excretion of Radioactivity after Parenteral Administration of Radioactive Polydiethylstilbestrol Phosphate to Rats and a Cow". Proc. Soc. Exp. Biol. Med. 117 (2): 394–8. doi:10.3181/00379727-117-29590. PMID 14233451. S2CID 28242978.
Perklev T, Gassner FX, Martin RP, Huseby RA, Shimoda W (1965). "Excretion of radioactivity by human subjects after ingestion of liver from cattle treated with labeled polydiethylstilbestrol phosphate". Proc. Soc. Exp. Biol. Med. 119 (4): 996–8. doi:10.3181/00379727-119-30359. PMID 5891085. S2CID 43341013.
Perklev T, Gassner FX, Hopwood ML (September 1967). "Distribution and excretion of 14C-labeled polydiethylstilbestrol phosphate in a steer". J. Anim. Sci. 26 (5): 1094–100. doi:10.2527/jas1967.2651094x. PMID 6077168.
Loew FM (October 1972). "The veterinarian and intensive livestock production: humane considerations". Can. Vet. J. 13 (10): 229–33. PMC 1695928. PMID 4562986.

ERTooltip Estrogen receptor

Agonists

Mixed
(SERMsTooltip Selective estrogen receptor modulators)

Antagonists

GPERTooltip G protein-coupled estrogen receptor

Agonists	2-Methoxyestradiol 7β-Hydroxyepiandrosterone Afimoxifene (4-hydroxytamoxifen) Aldosterone Atrazine Bisphenol A Daidzein DDT (p,p'-DDT, o',p'-DDE) Diarylpropionitrile Equol Estradiol Ethinylestradiol Fulvestrant (ICI-182780) G-1 Genistein GPER-L1 GPER-L2 Hydroxytyrosol Kepone Nicotinic acid Nicotinamide Nonylphenol Oleuropein PCBs (2,2',5'-PCB-4-OH) Propylpyrazoletriol Quercetin Raloxifene Resveratrol STX Tamoxifen Tectoridin
Antagonists	CCL18 Estriol G-15 G-36 MIBE
Unknown	Diethylstilbestrol Zearalenone

See also: Receptor/signaling modulators; Estrogens and antiestrogens; Androgen receptor modulators; Progesterone receptor modulators; List of estrogens

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