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In enzymology, a polygalacturonate 4-alpha-galacturonosyltransferase (EC 2.4.1.43) is an enzyme that catalyzes the chemical reaction

UDP-D-galacturonate + (1,4-alpha-D-galacturonosyl)n ${\displaystyle \rightleftharpoons }$ UDP + (1,4-alpha-D-galacturonosyl)n1

Thus, the two substrates of this enzyme are UDP-D-galacturonate and (1,4-alpha-D-galacturonosyl)n, whereas its two products are UDP and (1,4-alpha-D-galacturonosyl)n+1.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase. Other names in common use include UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase, uridine diphosphogalacturonate-polygalacturonate, and alpha-galacturonosyltransferase. This enzyme participates in starch and sucrose metabolism and nucleotide sugars metabolism.

Indications

Polygalacturonate salts can be used clinically to treat the GI reactions that are due to Quinidine.

References

• Villemez CL, Swanson AL, Hassid WZ (1966). "Properties of a polygalacturonic acid-synthesizing enzyme system from Phaseolus aureus seedlings". Arch. Biochem. Biophys. 116 (1): 446–52. doi:10.1016/0003-9861(66)90051-8. PMID 5961848.

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