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Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization. Two 2020 studies have shown that depleting PTB mRNA in astrocytes can convert these astrocytes to functional neurons. These studies also show that such a treatment can be applied to the substantia nigra of mice models of Parkinson's disease in order to convert astrocytes to dopaminergic neurons and as a consequence restore motor function in these mice.

See also

• Polypyrimidine tract

References

1. Valcárcel J, Gebauer F (November 1997). "Post-transcriptional regulation: the dawn of PTB". Current Biology. 7 (11): R705-8. Bibcode:1997CBio....7R.705V. doi:10.1016/S0960-9822(06)00361-7. PMID 9382788. S2CID 13820693.
2. Zhou H, Su J, Hu X, et al. (April 2020). "Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice". Cell. 181 (3): 590–603.e16. doi:10.1016/j.cell.2020.03.024. PMID 32272060. S2CID 215514410.
3. Qian H, Kang X, Hu J, et al. (June 2020). "Reversing a model of Parkinson's disease with in situ converted nigral neurons". Nature. 582 (7813): 550–556. Bibcode:2020Natur.582..550Q. doi:10.1038/s41586-020-2388-4. PMC 7521455. PMID 32581380. S2CID 220051280.

External links

• polypyrimidine+tract-binding+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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