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Pregnanetriol

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Pregnanetriol
Names
IUPAC name (20S)-5β-Pregnane-3α,17,20-triol
Systematic IUPAC name (1R,3aS,3bR,5aR,7R,9aS,9bS,11aS)-1--9a,11a-dimethylhexadecahydro-1H-cyclopentaphenanthrene-1,7-diol
Other names 5β-Pregnane-3α,17α,20α-triol
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.012.862 Edit this at Wikidata
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C21H36O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h13-18,22-24H,4-12H2,1-3H3/t13-,14+,15+,16+,17-,18-,19-,20-,21-/m0/s1Key: SCPADBBISMMJAW-UHHUKTEYSA-N
  • InChI=1/C21H36O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h13-18,22-24H,4-12H2,1-3H3/t13-,14+,15+,16+,17-,18-,19-,20-,21-/m0/s1Key: SCPADBBISMMJAW-UHHUKTEYBG
SMILES
  • O4C3(1(2(C)(CC1)(O)((O)C)CC2)CC3)(C)CC4
Properties
Chemical formula C21H36O3
Molar mass 336.516 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Pregnanetriol, or 5β-pregnane-3α,17α,20α-triol, is a steroid and inactive metabolite of progesterone.

Urine testing

Urine excretion of pregnanetriol can be measured over a period of 24 hours. Elevated urine pregnanetriol levels suggest adrenogenital syndrome. In monitoring treatment with cortisol replacement, elevated urine pregnanetriol levels indicate insufficient dosage of cortisol.

Reference ranges

For females:

  • 0 to 5 years: < 0.1 mg/24 hours
  • 6 to 9 years: < 0.3 mg/24 hours
  • 10 to 15 years: 0.1 to 0.6 mg/24 hours
  • 16 years and older: 0 to 1.4 mg/ 24 hours.

For males:

  • 0 to 5 years: < 0.1 mg/24 hours
  • 6 to 9 years: < 0.3 mg/24 hours
  • 10 to 15 years: 0.2 to 0.6 mg/24 hours
  • 16 years and older: 0.2 to 2 mg/ 24 hours

See also

Pregnanetriolone

References

  1. ^ online-family-doctor.com Pregnanetriol Retrieved April 2011
Endogenous steroids
Precursors
Corticosteroids
Glucocorticoids
Mineralocorticoids
Sex steroids
Androgens
Estrogens
Progestogens
Neurosteroids
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