Protein-coding gene in the species Homo sapiens
Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene .
This gene encodes subunit 3 of the splicing factor 3b protein complex . Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
Interactions
SF3B3 has been shown to interact with SF3B1 , Transcription initiation protein SPT3 homolog and TAF9 .
References
^ GRCh38: Ensembl release 89: ENSG00000189091 – Ensembl , May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000033732 – Ensembl , May 2017
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine ."Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Das BK; Xia L; Palandjian L; Gozani O; Chyung Y; Reed R (February 2000). "Characterization of a Protein Complex Containing Spliceosomal Proteins SAPs 49, 130, 145, and 155" . Mol Cell Biol . 19 (10): 6796–802. doi :10.1128/mcb.19.10.6796 . PMC 84676 . PMID 10490618 .
^ "Entrez Gene: SF3B3 splicing factor 3b, subunit 3, 130kDa" .
Will, Cindy L; Urlaub Henning; Achsel Tilmann; Gentzel Marc; Wilm Matthias; Lührmann Reinhard (September 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein" . EMBO J . 21 (18): 4978–88. doi :10.1093/emboj/cdf480 . ISSN 0261-4189 . PMC 126279 . PMID 12234937 .
^ Martinez, E; Palhan V B; Tjernberg A; Lymar E S; Gamper A M; Kundu T K; Chait B T; Roeder R G (October 2001). "Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo" . Mol. Cell. Biol . 21 (20): 6782–95. doi :10.1128/MCB.21.20.6782-6795.2001 . ISSN 0270-7306 . PMC 99856 . PMID 11564863 .
Further reading
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1" . DNA Res . 1 (1): 27–35. doi :10.1093/dnares/1.1.27 . PMID 7584026 . Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)" . DNA Res . 1 (1): 47–56. doi :10.1093/dnares/1.1.47 . PMID 7584028 . Bonaldo MF; Lennon G; Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 . PMID 8889548 . Mintz PJ, Patterson SD, Neuwald AF, et al. (1999). "Purification and biochemical characterization of interchromatin granule clusters" . EMBO J . 18 (15): 4308–20. doi :10.1093/emboj/18.15.4308 . PMC 1171507 . PMID 10428969 . Brand M, Moggs JG, Oulad-Abdelghani M, et al. (2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation" . EMBO J . 20 (12): 3187–96. doi :10.1093/emboj/20.12.3187 . PMC 150203 . PMID 11406595 . Gangloff YG, Pointud JC, Thuault S, et al. (2001). "The TFIID Components Human TAFII140 and Drosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger" . Mol. Cell. Biol . 21 (15): 5109–21. doi :10.1128/MCB.21.15.5109-5121.2001 . PMC 87236 . PMID 11438666 . Will CL, Schneider C, MacMillan AM, et al. (2001). "A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site" . EMBO J . 20 (16): 4536–46. doi :10.1093/emboj/20.16.4536 . PMC 125580 . PMID 11500380 . Martinez E, Palhan VB, Tjernberg A, et al. (2001). "Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo" . Mol. Cell. Biol . 21 (20): 6782–95. doi :10.1128/MCB.21.20.6782-6795.2001 . PMC 99856 . PMID 11564863 . Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis" . RNA . 8 (4): 426–39. doi :10.1017/S1355838202021088 . PMC 1370266 . PMID 11991638 . Scott MP, Zappacosta F, Kim EY, et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1" . J. Biol. Chem . 277 (31): 28238–46. doi :10.1074/jbc.M202783200 . PMID 12029088 . Will CL, Urlaub H, Achsel T, et al. (2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein" . EMBO J . 21 (18): 4978–88. doi :10.1093/emboj/cdf480 . PMC 126279 . PMID 12234937 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 . Cavusoglu N; Brand M; Tora L; Van Dorsselaer A (2003). "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis". Proteomics . 3 (2): 217–23. doi :10.1002/pmic.200390030 . PMID 12601814 . S2CID 6035986 . Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins" . Mol. Cell. Biol . 23 (21): 7437–47. doi :10.1128/MCB.23.21.7437-7447.2003 . PMC 207616 . PMID 14559993 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 . Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome" . RNA . 10 (6): 929–41. doi :10.1261/rna.7320604 . PMC 1370585 . PMID 15146077 . Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Curr. Biol . 14 (16): 1436–50. doi :10.1016/j.cub.2004.07.051 . PMID 15324660 . S2CID 2371325 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 . PMID 17353931 . Categories :
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