A splicing factor is a protein involved in the removal of introns from strings of messenger RNA, so that the exons can bind together; the process takes place in particles known as spliceosomes. Genes are progressively switched off as people age, and splicing factors can reverse this trend. Splicing factors regulate the binding of the snRNPs U1 and U2 to the 3' and 5' ends of the intron during splicing and can either be splicing promoters or splicing repressors.
In a research paper, splicing factors were found to be produced upon application of resveratrol analogues, which induced senescent cells to rejuvenate.
Splicing factor 3b
Splicing factor 3b is a protein complex consisting of the following proteins: PHF5A, SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6.
Notes
- ^ "Old human cells rejuvenated in breakthrough discovery on ageing".
- Wang, Z; Burge, CB (May 2008). "Splicing regulation: from a parts list of regulatory elements to an integrated splicing code". RNA. 14 (5): 802–13. doi:10.1261/rna.876308. PMC 2327353. PMID 18369186.
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